Both children with type 1 diabetes and their closest family members are at increased risk of mental health problems compared with those without the disease, according to a large study by researchers at Karolinska Institutet published in the journal Diabetes Care. The findings underscore the need for psychological consulting for both children and their families in diabetes care.
3D illustration of Type 1 Diabetes showing lower amount of insulin production in a diabetic patient. Image credit: scientificanimations.com via Wikimedia, CC-BY-SA-4.0
Research shows that children and adolescents with type 1 diabetes are at increased risk of mental health problems such as depression, anxiety and stress-related disorders. These co-morbidities can get in the way of optimal care.
Current guidelines from the International Society for Pediatric and Adolescent Diabetes (ISPAD) recommend screening for mental health problems in children with type 1 diabetes. Still, they do not adequately address the needs of family members, who are also at increased risk of mental health problems. Moreover, the reasons behind the association of familial mental health problems and type 1 diabetes are not fully understood.
“Many clinicians assume intuitively that diabetes in a child negatively affects the mental health of both the patient and the family members,” says Agnieszka Butwicka, assistant professor at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, and the study’s last senior author. “But we think the answer is not that simple. Our study indicates a genetic component could also be behind this association.”
Nearly doubled risk of depression
The study linked some 3.5 million people born in Sweden between 1973 and 2007 to their biological parents, full- and half-siblings and cousins. More than 20,000 people were diagnosed with childhood-onset type 1 diabetes and nearly double the risk of depression and around 1.6 times higher risk of anxiety and stress-related disorders than those without the disease.
Their parents and full siblings also had somewhat elevated risks of anxiety and stress-related disorders, albeit to a lesser degree. In contrast, their half-siblings and cousins had no or only marginally higher risks for some conditions.
“These results are of high clinical relevance because they mean that therapeutic intervention should involve close family members, not just patients,” Agnieszka Butwicka says.
Since parents-children and full-siblings share more genetic material (around 50 percent) than half-siblings (around 25 percent) and cousins (less than 12.5 percent), the researchers say the outcome supports the idea that genes may be a contributing factor to mental health problems in type 1 diabetes.
However, since this is only an observational study, they cannot conclusively say what causes the associations.
“More studies are needed to fully understand the underlying genetic and environmental contributions driving psychiatric disorders in type 1 diabetes,” says Shengxin Liu, PhD student at Karolinska Institutet and the study’s corresponding author.
Source: Karolinska Institutet