General – Innovita Research
April 12, 2021

Case Western Reserve awarded $3 million National Cancer Institute grant to apply AI to immunotherapy in lung cancer patients

Medical researchers from Case Western Reserve University, New York University (NYU), and University Hospitals have been awarded a five-year, $3 million National Cancer Institute grant to develop and apply artificial intelligence (AI) tools for predicting which lung cancer patients will respond to immunotherapy. A unique aspect of the Case Western […]
April 12, 2021

Leaking calcium in neurons an early sign of Alzheimer’s pathology

Alzheimer’s disease is known for its slow attack on neurons crucial to memory and cognition.  But why are these particular neurons in ageing brains so susceptible to the disease’s ravages, while others remain resilient? In a new study published in the journal Alzheimer’s & Dementia, The Journal of the Alzheimer’s […]
April 12, 2021

How to tame a restless genome

Short pieces of DNA—jumping genes—can bounce from one place to another in our genomes. When too many DNA fragments move around, cancer, infertility, and other problems can arise. Cold Spring Harbor Laboratory (CSHL) Professor & HHMI Investigator Leemor Joshua-Tor and a research investigator in her lab, Jonathan Ipsaro, study how cells safeguard […]
April 11, 2021

Scientists created a tool to measure social media's impact on teens' sleep

If you’ve ever worked in a school, you know how sleepy some teens are. Why is that? Why aren’t they sleeping well when they are supposed to be sleeping? Well, there are some factors but one of them is probably social media. Scientists at the University of Glasgow have now […]
April 11, 2021

Naked Mole Rats Employ Cholesterol Metabolism to Enable Cells to Resist the Senescent State

Naked mole-rats exhibit an unusually longevity, with a life span something like nine times as long as that of equivalently sized mammals. They are also highly resistant to cancer. This makes them an attractive subject for research into ways to treat aging and age-related disease. No one mechanism will be […]
April 11, 2021

Understanding how cancer can relapse

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options. Now, scientists at the University of Missouri and Yale University have discovered that one of these mutations — oncogenic RAS or RASV12 — is also responsible for the […]
April 11, 2021

Treating Sleep Apnea May Reduce Dementia Risk

A new study finds older adults who received positive airway pressure therapy prescribed for obstructive sleep apnea may be less likely to develop Alzheimer’s disease and other kinds of dementia. Researchers from Michigan Medicine’s Sleep Disorders Centers analyzed Medicare claims of more than 50,000 Medicare beneficiaries ages 65 and older who had been […]
April 11, 2021

Clinical trials assess best first-line drugs for epilepsy

Standard drugs remain the best first-line treatments for epilepsy, according to the results of two UK clinical trials led by the University of Liverpool. The Standard and New Antiepileptic Drugs (SANAD II) studies compared a range of antiepileptic drugs for how well they control seizures, their general tolerability and their […]
April 11, 2021

Artificial intelligence can accelerate clinical diagnosis of fragile X syndrome

An analysis of electronic health records for 1.7 million Wisconsin patients revealed a variety of health problems newly associated with fragile X syndrome, the most common inherited cause of intellectual disability and autism, and may help identify cases years in advance of the typical clinical diagnosis. Researchers from the Waisman […]
April 10, 2021

Researchers create a new human height inheritance model

Skoltech scientists and their colleagues have proposed a new human height inheritance model that accounts for the interaction between various factors that influence adult human height. The research was published in the European Journal of Human Genetics. Human height is a classical quantitative trait that depends on sex, genetics, and […]
April 10, 2021

Long Term Consequences of Brain Ischemia in the Development of Alzheimer's Disease

Transient ischemia is the loss of blood supply to tissue followed by its restoration, leading to cell death, tissue damage, and harmful cell signaling. While the paper here is focused on connecting the significant ischemia of stroke with the later development of Alzheimer's disease, it is also the case that […]
April 10, 2021

New national study of long-term impacts of debilitating lung damage from COVID-19

A new national study will investigate the long-term effects of lung inflammation and scarring from COVID-19. The study, launched with £2 million of funding from UK Research and Innovation (UKRI), aims to develop treatment strategies and prevent disability. Many people recovering from COVID-19 suffer from long-term symptoms of lung damage, including breathlessness, […]
April 10, 2021

‘Brain glue’ helps repair circuitry in severe TBI

At a cost of $38 billion a year, an estimated 5.3 million people are living with a permanent disability related to traumatic brain injury in the United States today, according to the Centers for Disease Control and Prevention. The physical, mental and financial toll of a TBI can be enormous, but […]
April 10, 2021

Long-Term Impact of COVID-19

People admitted to inpatient rehabilitation after hospitalization with COVID-19 showed deficits in mobility, cognition, speech, and swallowing at admission and improved significantly in all of these capabilities by the time they were discharged. However, a considerable number of patients exhibited residual deficits at discharge, highlighting the post-acute care needs of […]
April 10, 2021

An amyloid link between Parkinson’s disease and melanoma

On the surface, Parkinson’s disease — a neurodegenerative disorder — and melanoma — a type of skin cancer — do not appear to have much in common. However, for nearly 50 years, doctors have recognized that Parkinson’s disease patients are more likely to develop melanoma than the general population. Now, […]
April 9, 2021

Researchers advance genome mapping for critically-endangered sturgeon

In a genetics breakthrough that may help detect and conserve one of North America’s most endangered fish species, researchers from the U.S. Geological Survey’s Columbia Environmental Research Center and Southern Illinois University Carbondale recently produced offspring of endangered pallid sturgeon with DNA from only a single parent. These offspring are not […]
April 9, 2021

Research targets faster, safer source of islet cells for people with Type 1 diabetes

University of Alberta researchers are harnessing the power of artificial intelligence to find a safer, more personalized source of islet cells to treat Type 1 diabetes. The research project, a collaboration between the departments of surgery and computing science, aims to use AI to analyze images to speed up the process and reduce […]
April 9, 2021

Chromosome 8 assembly reveals novel genes, disease risks

The full assembly of human chromosome 8 is reported this week in Nature.  While on the outside this chromosome looks typical, being neither short nor long or distinctive, its DNA content and arrangement are of interest in primate and human evolution, in several immune and developmental disorders, and in chromosome sequencing […]
April 9, 2021

Tau Knockout in Normal Mice Improves Mitochondrial Function and Slows Cognitive Decline

Tau is involved in Alzheimer's disease and other tauopathies; it is one of the few proteins in the body capable of becoming naturally altered in ways that encourage aggregation of the protein into solid deposits that are toxic to cells. Tau is highly expressed in nerve cells, and helps in […]
April 9, 2021

Getting to the Core of HIV Replication

HIV-1 viral capsid simulations on XSEDE-allocated Stampede2, Bridges, Darwin systems uncover nucleotide entry mechanism. Viruses lurk in the grey area between the living and the nonliving, according to scientists. Like living things, they replicate but they don't do it on their own. The HIV-1 virus, like all viruses, needs to […]
April 9, 2021

Chronic sinus inflammation appears to alter brain activity

The millions of people who have chronic sinusitis deal not only with stuffy noses and headaches, they also commonly struggle to focus, and experience depression and other symptoms that implicate the brain’s involvement in their illness. New research links sinus inflammation with alterations in brain activity, specifically with the neural […]
April 9, 2021

New study probes the effects of opioid use during pregnancy

A new UO study is examining the effects of opioids on an understudied population: developing infants. Human physiology associate professor Adrianne Huxtable is focusing her newest research project on the effects of opioids during pregnancy on essential breathing circuits. It is a research question that hasn’t been well-examined, despite the […]
April 9, 2021

Seeking the cellular mechanisms of disease, with help from machine learning

Caroline Uhler blends machine learning, statistics, and biology to understand how our bodies respond to illness. Caroline Uhler’s research blends machine learning and statistics with biology to better understand gene regulation, health, and disease. Despite this lofty mission, Uhler remains dedicated to her original career passion: teaching. “The students at […]
April 9, 2021

Reversing a genetic cause of poor stress responses in mice

Everyone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well as others. In a few cases, the cause is genetic. In humans, mutations in the OPHN1 gene cause a rare X-linked disease that includes poor stress tolerance. Cold Spring Harbor Laboratory (CSHL) […]
April 9, 2021

Artificial Intelligence can see genetic mutations in the cancer cells that escape the human eye

Myelodysplastic syndrome (MDS) is a disease, which can develop into acute leukaemia. It starts in the stem cells in the bone marrow, disturbing the maturing and differentiation process of blood cells. Now scientists at the University of Helsinki have demonstrated that artificial intelligence (AI) can effectively spot  genetic mutations in […]
April 9, 2021

Artificial Intelligence identified three types of multiple sclerosis

The biggest advantage of Artificial Intelligence (AI) is its ability to analyse large amounts of data and categorize it in a way that is not immediately obvious to people. For example, now AI identified three new subtypes of multiple sclerosis (MS) in a recent UCL research. Scientists believe this will […]
April 9, 2021

Artificial Intelligence can help developing proteins quicker and cheaper

Artificial Intelligence (AI) is a tool, which enables people to analyse huge pools of data very quickly and with high degree of accuracy. AI could speed up a lot of our scientific work. For example, researchers at Chalmers University of Technology, Sweden, have found that AI is able to generate […]
April 8, 2021

Study reveals how long-term infection and inflammation impairs immune response as we age

Humans are born with tens of thousands of hematopoietic stem cells (HSCs) that collectively ensure lifelong production of blood and immune cells that protect us from infections. HSCs can either duplicate to produce more stem cell progeny or differentiate to produce distinct immune cell lineages, an extremely critical decision that […]
April 8, 2021

Face, brain development tightly linked, study finds

Researchers at Stanford and KU Leuven have identified more than 70 genes that affect variation in both brain and facial structure. The genes don’t influence cognitive ability, further debunking beliefs that intelligence can be assessed by facial features. Even when you assume your best poker face, you reveal something about […]
April 8, 2021

U of A chemists discover how a plaque-fighting protein protects against Alzheimer’s

Scientists at the University of Alberta have identified a mechanism for a protein that decreases the chance of developing Alzheimer’s disease—a discovery that highlights a new potential avenue for developing therapeutic treatments. The protein, called CD33, is known for its connection to Alzheimer’s disease susceptibility, but its exact role was […]