General – Innovita Research
July 17, 2019

Eisai's Anticancer Agent Halaven Approved for Treatment of Locally Advanced or Metastatic Breast Cancer in China

Eisai has received a New Drug Approval for its in-house developed anticancer agent Halaven (eribulin mesylate) for use in the treatment of patients with locally advanced or metastatic breast cancer, previously treated with at least two prior chemotherapy regimens, including an anthracycline and a taxane, from the China National Medical […]
July 17, 2019

https://today.uconn.edu/2019/07/common-steroid-soften-tumors-chemo/

A common drug used to alleviate side effects of cancer treatment may also make the treatment more successful if given beforehand, report a consortium of research institutions including the University of Connecticut. Dexamethasone, a steroid often given to decrease swelling and nausea, and relieve side effects of chemotherapy treatments for […]
July 17, 2019

Cancer Device Created at Rutgers to See if Targeted Chemotherapy is Working

Rutgers researchers have created a device that can determine whether targeted chemotherapy drugs are working on individual cancer patients. The portable device, which uses artificial intelligence and biosensors, is up to 95.9 percent accurate in counting live cancer cells when they pass through electrodes, according to a study in the journal Microsystems […]
July 17, 2019

HIV Persists in Spinal Fluid, Linked to Cognition Problems

Even after nearly a decade of strict HIV treatment, cells sheltering the virus could be found in the cerebrospinal fluid of half of participants in a national clinical trial of people living with HIV. Moreover, those participants had a higher likelihood of cognitive deficits than their peers without cells harboring […]
July 17, 2019

At rest your brain is constanly pressing "Replay" button – it helps you deal with unfamiliar situations

Human brain is the most mysterious machine in nature. We hardly know anything about it. Scientists from UCL and University of Oxford have just found that when we’re resting our brains spontaneously replay our experiences. This may be the basis of our powerful reasoning abilities. That is why having experience […]
July 17, 2019

Our platelet cells, which prevent us from bleeding all the time, evolved 300 million years ago

Everything in nature is interrelated. Evolution gave us incredible capabilities and pretty good bodies, but some features that we enjoy were actually evolved by other organisms. For example, according to a new UCL and Yale University study, platelet cells, which prevent mammals from bleeding non-stop came from an egg-laying animal […]
July 16, 2019

HIIT is great at reducing the risk of age-related dementia

Dementia is a daunting condition, which is in the cards for many. It is caused by a variety of factors and can be attributed to several different diseases. With our population ageing rapidly, more and more people will be suffering from dementia in the near future. But what can we […]
July 16, 2019

‘Magnetic’ air pollution putting city dwellers at risk of heart disease

The hearts of people living in highly polluted urban areas could be up to ten times more polluted than those living in places with cleaner air, putting them at increased risk of heart disease, according to new research. Scientists, led by Professors Barbara Maher of Lancaster University and Lilian Calderón-Garcidueñas […]
July 16, 2019

Healthy blood vessels may be the answer to Alzheimer’s prevention

USC research into Alzheimer’s — which will be on display at the upcoming Alzheimer’s Association International Conference — has uncovered much about the disease, including establishing a link between cardiovascular health and a fully functioning brain. If you’re worried about Alzheimer’s disease, your best shot at prevention could be maintaining […]
July 16, 2019

Healthy lifestyle may offset genetic risk of dementia

Living a healthy lifestyle may help offset a person’s genetic risk of dementia, according to new research. The study was led by the University of Exeter – simultaneously published in JAMA and presented at the Alzheimer’s Association International Conference 2019 in Los Angeles. The research found that the risk of dementia […]
July 16, 2019

Targeting a key protein may keep ovarian cancer cells from spreading

Preventing a protein from doing its job may keep a certain type of ovarian cancer cell from growing and dividing uncontrollably in the lab, according to a new study from Penn State College of Medicine. In a study with cell cultures, the researchers identified the protein as a potential therapeutic target for high-grade […]
July 16, 2019

New study discovers genetic changes linked to leukaemia in children with Down’s syndrome

Researchers at the University of Oxford, in collaboration with colleagues from Hannover Medical School and Martin-Luther-University Halle-Wittenberg, have discovered the specific gene mutations that are required for the development of leukaemia in children with Down’s syndrome. Children with Down’s syndrome have a 150-fold increased risk of myeloid leukaemia, and while […]
July 16, 2019

New ALS biomarkers, potential new drug targets described by researchers

Amyotrophic lateral sclerosis, or ALS, is an adult-onset neurodegenerative disease that causes paralysis and ultimately death when the nerves enervating the lungs cease to carry the signals needed for breathing. The disease has what is called a “focal onset,” where paralysis starts with an arm or a leg and spreads […]
July 15, 2019

UC San Diego Cancer Scientists Identify New Drug Target for Multiple Tumor Types

A research team headed by scientists at University of California San Diego School of Medicine and the Ludwig Institute for Cancer Research at UC San Diego has identified an enzyme involved in remodeling the plasma membrane of multiple cancer cell types that is critical to both survival of tumors and […]
July 15, 2019

New vaccine strategy boosts T-cell therapy

A promising new way to treat some types of cancer is to program the patient’s own T cells to destroy the cancerous cells. This approach, termed CAR-T cell therapy, is now used to combat some types of leukemia, but so far it has not worked well against solid tumors such […]
July 15, 2019

Southampton scientists make breakthrough in search for future drugs for age-related blindness

University of Southampton researchers have developed an innovative solution to treating sight loss in old age. Led by Professors Andrew Lotery, Jessica Teeling and Dr Arjuna Ratnayaka, the study has been able to replicate important features of dry age-related macular degeneration (AMD) in mice. These mice quickly develop damage in their retinas similar to […]
July 15, 2019

High Intensity Interval Training (HIIT) may prevent cognitive decline

High intensity interval training (HIIT) may be doing more than just keeping you fit and strong – it may also help prevent age-related cognitive illnesses, such as dementia. A University of Queensland study found high intensity interval exercise may be more effective than continuous exercise in increasing brain blood flow […]
July 15, 2019

Infection-fighting protein senses protein misfolding in non-infected cells

Researchers at the University of Toronto have uncovered an immune mechanism where host cells combat bacterial infection – and that a protein crucial to the process can sense and respond to misfolded proteins in all mammalian cells. The protein is called heme-regulated inhibitor, or HRI, and the researchers showed that […]
July 15, 2019

Unexpected effect of MS drug

Researchers at Karolinska Institutet in Sweden have studied the mechanism of action of a drug used to treat multiple sclerosis. The results, which are published in the journal Nature Communications, show that the drug affects cells in the innate immune system and that there is an unexpected link between therapeutic […]
July 15, 2019

Gene Switches for Brain Inflammation

A new study by Harvard Medical School scientists at Massachusetts General Hospital is offering clues about how to prevent inflammation of brain tissue, which promotes Alzheimer’s disease. The findings of this study, published in the journal Neuron, could contribute to the development of new therapies for Alzheimer’s disease. It’s known that […]
July 15, 2019

Cardiac Genetic Mutation May Not Always Predict Heart Disease

Researchers at Penn Medicine and Geisinger find only 5 percent of patients with a mutation of the TTN gene have dilated cardiomyopathy, despite changes in heart function. More than 750,000 people in the United States have dilated cardiomyopathy, a potentially life-threatening condition in which the heart’s main pumping chamber, the […]
July 15, 2019

Surgery before pregnancy linked to higher risk of opioid withdrawal in babies

Babies whose mothers underwent surgery before pregnancy have an increased risk of opioid withdrawal symptoms at birth, according to a new study done at the University of Montreal Hospital Research Centre (CRCHUM) and published in the Canadian Medical Association Journal. “Use of opioids for pain control after surgery may increase the risk of […]
July 12, 2019

New findings about how Parkinson’s disease develops

A new study by researchers at Karolinska Institutet shows that the protein alpha-synuclein, which accumulates in patients with Parkinson’s disease, occurs bound to lipoprotein particles in cerebrospinal fluid, which may explain how the disease spreads in the nervous system. The study is published in the scientific journal PNAS. Some 23,000 […]
July 12, 2019

Neural sleep patterns emerged at least 450 million years ago

Researchers at the Stanford University School of Medicine have found that neural signatures in sleeping zebrafish are analogous to those of humans, suggesting that the brain activity evolved at least 450 million years ago, before any creatures crawled out of the ocean. Scientists have known for more than 100 years that fish […]
July 12, 2019

An ‘EpiPen’ for spinal cord injuries

An injection of nanoparticles can prevent the body’s immune system from overreacting to trauma, potentially preventing some spinal cord injuries from resulting in paralysis. The approach was demonstrated in mice at the University of Michigan, with the nanoparticles enhancing healing by reprogramming the aggressive immune cells—call it an “EpiPen” for […]
July 12, 2019

For malnourished children, new therapeutic food boosts gut microbes, healthy development

A new type of therapeutic food, specifically designed to repair the gut microbiomes of malnourished children, is superior to standard therapy in an initial clinical trial conducted in Bangladesh. An interdisciplinary team of investigators from Washington University School of Medicine in St. Louis and the International Centre for Diarrhoeal Disease […]
July 12, 2019

Hormone Therapy for Prostate Cancer May Raise Risk of Alzheimer’s, Dementia

For patients with prostate cancer, treating the disease with androgen deprivation therapy (ADT) is linked to a higher likelihood of being diagnosed with Alzheimer’s disease or dementia, compared to patients who do not receive the therapy, according to a study from researchers in the Perelman School of Medicine at the […]
July 12, 2019

Scientists use time travel to trace how cancer evolves

It’s possible to take precancerous cells back in time, so to speak, revealing individual DNA mutations in their earliest state and the likely sequence in which those mutations were acquired, according to scientists in Seattle. The discovery could shed light on the natural rules that govern how cancers evolve through […]
July 12, 2019

Patterns in DNA reveal hundreds of unknown protein pairings

Sequencing a genome is getting cheaper, but making sense of the resulting data remains hard. Researchers have now found a new way to extract useful information out of sequenced DNA. By cataloging subtle evolutionary signatures shared between pairs of genes in bacteria, the team was able to discover hundreds of previously […]
July 11, 2019

Researchers identify cancer-killing capability of lesser known immune cells

Researchers at Trinity College Dublin have identified, for the first time in oesophageal cancer, the cancer killing capability of a lesser-known type of immune cell, presenting a new potential therapeutic target. Their research has been published in the international journal Frontiers in Immunology. Oesophageal cancer is a very aggressive type […]