General – Page 106 – Innovita Research
July 21, 2021

Research suggests how tumors become aggressive prostate cancer

The genetic changes that underlie an especially lethal type of prostate cancer have been revealed in a new study by investigators at Weill Cornell Medicine. Learning more about what causes this type of cancer, called neuroendocrine prostate cancer (NEPC), could lead to new approaches for treating it. Most early stage […]
July 21, 2021

Treatment with endothelial cells reverses emphysema in model

The specialized endothelial cells that line the blood vessels in the lung may hold the key to treating the common and often-fatal lung disease emphysema, according to a study from researchers at Weill Cornell Medicine and NewYork-Presbyterian. In the study, published in the Journal of Experimental Medicine, the researchers showed […]
July 21, 2021

Novel autoantibody adds fuel to COVID-19 “firestorm” of inflammation, blood clots

Researchers at Michigan Medicine have discovered yet another functional autoantibody in COVID-19 patients that contributes to the disease’s development and the “firestorm” of blood clots and inflammation it induces. A growing body of studies suggests COVID-19 emulates many aspects of systemic autoimmune disorders, including the release of a flurry of […]
July 21, 2021

Fatty liver more common in children of mothers with obesity

Children and young people whose mothers had a BMI greater than 30 during early pregnancy are at an increased risk of fatty liver disease. This is shown in a register-based study from Karolinska Institutet and Harvard University published in the journal Journal of Hepatology. As obesity rates increase also in […]
July 20, 2021

Taking on Harmful Cells That Contribute to Age-Related Diseases

A Tufts scientist is testing senolytics to counter senescent cells that promote afflictions like arthritis and Parkinson's disease. It’s not the fountain of youth, but a fast-emerging class of drugs could bring us closer to achieving the age-old quest for longer life, better health, and greater vitality. The drugs, called […]
July 20, 2021

A noninvasive test to detect cancer cells and pinpoint their location

Diagnostic nanoparticles could be used to monitor tumor recurrence after treatment or to perform routine cancer screenings. Most of the tests that doctors use to diagnose cancer — such as mammography, colonoscopy, and CT scans — are based on imaging. More recently, researchers have also developed molecular diagnostics that can […]
July 20, 2021

Pandemic had greater impact on younger age group mortality in deprived areas

In the first year of the Covid-19 pandemic, deprived areas suffered more excess deaths than affluent areas, with a disproportionate impact on their younger age groups according to the early draft of a new study. In addition to the deaths from COVID-19, longstanding socioeconomic and geographical health inequalities for a […]
July 20, 2021

Fungi that live in the gut influence health and disease

Bacteria’s role in gut health has received a lot of attention in recent years. But new research led by scientists at the University of Utah Health shows that fungi—another microorganism that lives within us—may be equally important in health and disease. Fungi thrive in the healthy gut, but they can also […]
July 20, 2021

Team to test if video games can relieve late-life depression

University of Utah Health scientists have received a five-year, $7.5-million grant from the National Institute of Mental Health to test whether a web-based intervention that resembles a video game can alleviate depression in older adults in the comfort and safety of their own homes. The University of Connecticut will also participate […]
July 19, 2021

Combining low-dose radiotherapy with immunotherapy eradicates metastatic cancer in mice

More doesn’t necessarily mean better — including in cancer treatment. University of Wisconsin–Madison and University of Pittsburgh School of Medicine scientists report today in the journal Science Translational Medicine that combining targeted radiopharmaceutical therapy with immunotherapy significantly boosts eradication of metastatic cancer in mice, even when the radiation is given […]
July 18, 2021

Stem Cell Transplantation to Treat Chronic Inflammation and Frailty

Today's open access commentary is a good companion piece to a recent paper covering the use of mesenchymal stem cell therapies to suppress age-related chronic inflammation. These first generation stem cell therapies have proven to be unreliable when it comes to the original goal of regeneration of organ function, but […]
July 18, 2021

Combining low-dose radiotherapy with immunotherapy eradicates metastatic cancer in mice

More doesn’t necessarily mean better — including in cancer treatment. University of Wisconsin–Madison and University of Pittsburgh School of Medicine scientists report today in the journal Science Translational Medicine that combining targeted radiopharmaceutical therapy with immunotherapy significantly boosts eradication of metastatic cancer in mice, even when the radiation is given […]
July 17, 2021

Chronic Inflammation Negatively Impacts Proteostasis in Aging Tissues

Proteostasis describes the steady state of a cell, maintaining an appropriate balance of various forms of protein machinery in order to enable continued normal function. With advancing age, proteostasis becomes disrupted in numerous complicated ways. This is a downstream outcome of underlying molecular damage, the reactions to that damage, and […]
July 17, 2021

Getting to the Heart of Genetic Cardiovascular Diseases: How One Penn Researcher is Using Her Expertise to Help Patients Lead More Active Lives

When she isn’t pursuing her favorite heart-pumping activities of running, swimming, or cycling, Sharlene M. Day, MD, a Presidential Associate Professor of Cardiovascular Medicine and director of Translational Research for the Penn Cardiovascular Institute, is focused on the heart in another way; trying to unlock and treat the mysteries of genetic […]
July 16, 2021

Ferroptosis in Aging

Ferroptosis is a mode of programmed cell death that manages to be both fairly well explored in the broader research community and far less visible than other programmed cell death processes. It was first named and described about a decade ago, though of course researchers have long explored aspects of […]
July 16, 2021

A Breakthrough in Photodynamic therapy

An international team led by physics researchers at The University of Texas at Arlington has published a paper in the high-impact journal Bioactive Materials that describes a breakthrough method of photodynamic therapy (PDT), an emerging cancer treatment. Nil Kanatha Pandey, a doctoral student in physics Professor Wei Chen’s lab, is the first […]
July 16, 2021

Memory-making involves extensive DNA breaking

The urgency to remember a dangerous experience requires the brain to make a series of potentially dangerous moves: Neurons and other brain cells snap open their DNA in numerous locations — more than previously realized, according to a new study — to provide quick access to genetic instructions for the mechanisms […]
July 15, 2021

Breakthrough into leading cause of blindness

A University of Manchester led a team of scientists has discovered that the most common form of adult blindness is probably caused by a failure of at least one of five proteins to regulate the immune system. The breakthrough could one day herald the development of transformative treatments for developing […]
July 15, 2021

Using “guilt by association” to classify cells

Biologists are trying to figure out what makes a cell unique in form and function. But they are not certain which components are key to making similar cells behave differently. Cold Spring Harbor Laboratory (CSHL) Associate Professor Jesse Gillis and his lab are tackling this problem with a new statistical method: they […]
July 15, 2021

Preventing lung cancer’s unwelcome return

When a doctor gives a patient antibiotics for a bacterial infection, they usually require them to finish the entire treatment, even when symptoms go away. This is to ensure the drugs kill off any remaining bacteria. Cold Spring Harbor Laboratory (CSHL) Visiting Scientist Raffaella Sordella investigated a similar problem that occurs in […]
July 15, 2021

A system for the early detection of tumour cells has been developed

Altum Sequencing, a start-up in the biotechnology sector that is part of the Universidad Carlos III de Madrid’s (UC3M) Incubation and Acceleration of Companies and Industrial PhD programmes, has patented a system that allows for the early identification of tumour-specific genetic markers and the quantification of cancer cells following responses […]
July 15, 2021

COVID-19 vaccine antibodies weaker vs. Delta/Kappa viral variants

Antibodies induced by currently available mRNA vaccines can still neutralize the Delta and Kappa variants of the SARS-CoV-2 virus, but do so at a reduced potency, according to a report published in the New England Journal of Medicine. The Delta variant, first identified in India and previously known as B.1.617.2, is […]
July 15, 2021

Immune system “clock” predicts illness and mortality

You’re as old as your immune system. Investigators at the Stanford University School of Medicine and the Buck Institute for Research on Aging have built an inflammatory-ageing clock that’s more accurate than the number of candles on your birthday cake in predicting how strong your immune system is, how soon […]
July 14, 2021

Species of gut bacteria linked to enhanced cognition and language skills in infant boys

Infant boys with a higher composition of a particular gut microbiota show enhanced neurodevelopment, according to a new study. The University of Alberta-led research followed more than 400 infants from the CHILD Cohort Study (CHILD) at its Edmonton site. Boys with a gut bacterial composition that was high in the bacteria Bacteroidetes […]
July 14, 2021

The long view on COVID-19 vaccine safety and efficacy

The mRNA vaccines for COVID-19, made by Pfizer/BioNTech and Moderna, are among the most powerful vaccines the world has ever seen. According to clinical trial data, they are more than 94% effective at preventing symptomatic disease, with real-world data bearing out that success. The other vaccine currently available in the […]