General

Cancer is relentless and resilient. When a drug blocks a cancer cell’s main survival pathway, the cell avoids the obstacle by taking different pathways or detours to save itself. This tactic is called “developing resistance,” and it’s one of the key challenges researchers face when seeking effective therapeutics to combat […]

Tel Aviv University and Sheba Medical Center researchers say they have discovered why more than half of patients with metastatic melanoma do not respond to immunotherapy cancer treatments. Wielding proteomics, an innovative “protein mapping” approach, a team of researchers led by Prof. Tami Geiger, Prof. Gal Markel, and Dr. Michal Harel of TAU's Sackler School of […]

Although the number of women being diagnosed and dying of ovarian cancer is declining, recurrence, drug resistance and mortality remain high for women with high-grade serous ovarian carcinoma, the most common form of epithelial ovarian cancer. A new study in the journal eLife by University of California San Diego School of Medicine […]

Bioengineers and biologists at the University of California San Diego have developed a method to significantly extend the life of gene circuits used to instruct microbes to do things such as produce and deliver drugs, break down chemicals and serve as environmental sensors. Most of the circuits that synthetic biologists […]

The physical activity guidelines issued today by the four Chief Medical Officers (CMOs) of England, Scotland, Wales and Northern Ireland, offer advice to all age groups and – for the first time – pregnant women, new mums and disabled adults. Drawing on the most up-to-date scientific evidence for the benefits of physical activity, […]

Chronic conductive hearing loss, a condition that can result from middle-ear infections, may interfere with  speech recognition deficits, according to the results of a new study led by Harvard Medical School scientists at Massachusetts Eye and Ear and published in the journal Ear and Hearing. This  finding suggests that not properly […]

Newborns whose mothers spent more than one week on bedrest had poorer health outcomes, according to a new study out of the University of Alberta that further challenges beliefs about pregnancy and activity levels. A team led by cardiovascular health researcher Margie Davenport conducted a review of every available randomized controlled trial of prenatal […]

Much research has pointed to how an unhealthy diet correlates to obesity, but has not explored how diet can bring about neurological changes in the brain. A recent Yale study has discovered that high-fat diets contribute to irregularities in the hypothalamus region of the brain, which regulates body weight homeostasis […]

Glycans, or complex sugars, cover the surfaces of our cells and play a key role in biological processes ranging from interacting with other cells to recognizing and fighting pathogens. With cancer, for example, they mediate the mechanisms controlling cell division, growth and mobility that affect tumor development. Glycans are ubiquitous, but […]

Rheumatoid arthritis, vasculitis and other inflammatory autoimmune diseases have a huge impact on patients’ quality of life. Autoimmune diseases, characterized by the immune system attacking the body, affect 5 to 10% of the global population. Women are affected more usually than men. It is treatable, but autoimmune disease is incurable. […]

Researchers at IMDEA Nanociencia investigate the efficiency of gold nanoclusters as drug carriers against cancer cells. Chemotherapy is one of the most used treatments against cancer, together with surgery and radiotherapy. In a chemotherapy treatment, one or several drugs are administered to the patient to remove or damage cancer cells. […]

Ruth M. Risueño leads the Leukaemic Stem Cell group of the Josep Carreras Leukaemia Research Institute. This group investigates Acute Myeloid Leukaemia (AML) and the cell population responsible for the disease spreading, persisting, and if it has been treated and overcome, reappear. AML is one of leukaemia with the worst […]

The same genetic mutations that can trigger cancer in some tissues are relatively harmless in others. A new Yale study has identified an unlikely source of protection against some forms of skin cancer — hair follicle regeneration. The regeneration of hair follicles protects against tumor growth even in the presence […]

Young women with early stage ovarian cancer can undergo fertility-preserving surgery without affecting the safety of their cancer treatment, researchers from Karolinska Institutet in Sweden report in a national study published in the journal Gynecologic Oncology. Non-epithelial ovarian cancer (NEOC) is an unusual form of cancer most commonly diagnosed in […]

Another collaborative project from a nanoparticles expert at The University of Texas at Arlington has yielded promising results in the search for more effective, targeted cancer treatments. Wei Chen, in collaboration with colleagues from the University of Rhode Island and Brown University, recently published a new paper in the Proceedings […]

Scientists from the National Institutes of Health and Cincinnati Children’s Hospital Medical Center have devised a potential treatment against a common type of leukemia that could have implications for many other types of cancer. The new approach takes aim at a way that cancer cells evade the effects of drugs, […]

The number of overweight and obese preschool-aged children is on the decline in Alberta, but severe obesity remains virtually unchanged, according to a new study. Researchers examined data from more than 160,000 Alberta children between the ages of four and six from 2010 to 2017. They found the prevalence of […]

Ad26 is a virus of great interest to the scientific and medical community. Ad26 is both a human pathogen causing severe respiratory distress, and potentially death in vulnerable patients, and a key component in new vaccines to fight deadly diseases. An Ad26 based vaccine is currently being deployed in Africa […]

Researchers and clinicians have long understood that depression and other mood disorders in mothers can have substantial, detrimental effects on the mental health of children in their care. In fact, maternal depression is now recognized as one of the most important risk factors in the cognitive and socioemotional development of […]

Scientists also report that even a mild hit or blast to the brain can benefit from early detection, treatment. WEST LAFAYETTE, Ind. – A traumatic brain injury is often easily suspected and can be confirmed and treated if necessary following an injury using a blood analysis, but scientists are reporting […]

Sonia Guil, leader of the Regulatory and Chromatin RNA group of Josep Carreras Leukemia Research Institute, and Lourdes Farré of ProCURE (Idibell) have discovered an intermediate molecule expressed from a region of the non-coding genome that is key to the development and differentiation of cells, and for the expansion of […]

Scientists discover the secret behind some protein transporters’ superiority. One transporter, MAE1, can export organic acids out of yeast spending close-to-zero energy. Organic acids are utilized as building blocks for plastic and rubber, and the finding could become important in industrial biotech. In a new study published in PNAS, scientists […]

Schizophrenia affects more than 21 million people worldwide. It is a mental disorder, characterized by a decreased ability to understand reality. People with this condition suffer from unclear or confused thinking, hearing voices, violent thoughts and other symptoms. Men are affected more often than women, which is why scientists set […]

Patients with similar liver cancer characteristics on the waitlist for a liver transplant had significantly worse outcomes with public insurance compared to Kaiser Permanente or other private insurance, according to a study by researchers at UC San Francisco. Their findings appeared online in JAMA Network Open. “Public insurance should be […]

In 2003, a German neuropathologist proposed that Parkinson’s disease, which attacks the brain, actually might originate from the gut of the patients. Researchers from Aarhus have now delivered decisive supportive evidence after seeing the disease migrate from the gut to the brain and heart of laboratory rats. The scientific journal Acta […]

Blocking a kinase known as CDK7 sets off a chain reaction that results in the death of prostate cancer cells that have spread and are resistant to standard therapies, according to a new study from researchers in the Abramson Cancer Center at the University of Pennsylvania. The team identified the role […]

Recently the National Institutes of Health called on researchers to make the standards and practices for conducting early stage, or preclinical, medical research on animals more like those used for clinical trials. To facilitate this change, NIH will fund a nationwide preclinical trial platform designed to systematically and efficiently test […]

An extreme case of “fussy” or “picky” eating caused a young patient’s blindness, according to a new case report published in Annals of Internal Medicine. The University of Bristol researchers who examined the case recommend clinicians consider nutritional optic neuropathy in any patients with unexplained vision symptoms and poor diet, […]

Immunity against mumps virus appears insufficient in a fraction of college-aged people who were vaccinated in childhood, research from Emory Vaccine Center and the Centers for Disease Control and Prevention indicates. The findings highlight the need to better understand the immune response to mumps and mumps vaccines. The results of […]

New research from the University of Maryland and the National Institutes of Health reveals a new role for the enzyme telomerase. Telomerase’s only known role in normal tissue was to protect certain cells that divide regularly, such as embryonic cells, sperm cells, adult stem cells and immune cells. Scientists thought […]