General

The neurodegenerative disease known as frontotemporal dementia (FTD) causes untold suffering. As neurons die in regions of the brain important for maintaining our personalities and living a purposeful life, patients experience steadily worsening cognitive and behavioural symptoms, and the disease is generally fatal within a decade of diagnosis. Though FTD […]

An enzyme proven to help regrow damaged nerve tissue in animals but too unstable for use in humans has been redesigned for stability in research co-led by Marian Hettiaratchi of the Phil and Penny Knight Campus for Accelerating Scientific Impact at the University of Oregon. With stability added, the enzyme […]

The world’s scientific community must engage with a broad range of stakeholders to develop guidelines on embryo and embryoid research, according to a new paper from Rice University’s Baker Institute for Public Policy. Human embryo and embryoid research have expanded in recent years due to technological advances. But inconsistent or ambiguous restrictions […]

A new study from Washington University School of Medicine in St. Louis identifies a specific gene’s previously unknown role infertility. When the gene is missing in fruit flies, roundworms, zebrafish and mice, the animals are infertile or lose their fertility unusually early but appear otherwise healthy. Analyzing genetic data in […]

Results Lay Groundwork for New, More Targeted Immune Therapies. New UC San Francisco research sheds light on how immune system B cells that infiltrate the central nervous system may drive multiple sclerosis (MS), pointing the way to a new generation of targeted immune therapies to halt the progression of the […]

Mitochondria are the power plants of our cells and play an important role in providing energy for normal function of the tissues in our body. Nerve cells are particularly dependent on mitochondria for their activity and decreased mitochondrial function is seen in both inherited and more common age-associated forms of […]

Research published in Nature Medicine examines the clinical characteristics of paediatric inflammatory multisystem syndrome (PIMS-TS). PIMS-TS is a rare syndrome which has emerged in a small number of children during the COVID-19 pandemic. The condition causes severe inflammation in blood vessels and can lead to heart damage. A team from […]

A recent study in Science Advances by researchers at Karolinska Institutet and Max Planck Institute shows that neurons can counteract degeneration and promote survival by adapting their metabolism. It challenges the long-standing view that neurons cannot adjust their metabolism and therefore irreversibly degenerate. These findings may contribute to developing therapeutic […]

Researchers at Vanderbilt University have, for the first time, being able to trigger the specific immune system response required to reverse the course of small intestinal inflammation by inducing the production of tuft cells, very rare epithelial cells that sense and respond to parasites. The breakthrough has the potential to […]

New research could improve the odds that people with the obsessive-compulsive disorder will receive a therapy that really works for them – something that eludes more than a third of those who currently get OCD treatment. The study, performed at the University of Michigan, suggests the possibility of predicting which […]

Pancreatic islet transplants, which revive insulin production to treat type 1 diabetes, only last an average of three years. By learning from a groundbreaking cancer treatment strategy based on a recent Nobel Prize-winning discovery, researchers at the Georgia Institute of Technology and the University of Missouri developed a new microgel […]

Small particles released by cancer cells contain specific proteins that may be used in a blood test to detect cancer at an early stage, according to a study published in the scientific journal Cell by a group of investigators from US institutions, and including a principal author from LiU. Early […]

A new diagnostic tool that can predict whether a cancer patient would respond to immunotherapy treatment has been developed by scientists at the University of Bath. This advance in precision medicine will allow clinicians to tailor treatments specifically to patients and avoid treatment paths that are unlikely to be successful. […]

Childhood and adolescent obesity is projected to contribute up to 14 per cent of overall risk of Multiple Sclerosis (MS) in 2035, according to research led by Queen Mary University of London. Previous studies have estimated that 53 per cent of MS risk is directly attributable to environmental factors, and […]

When autumn comes we wrap ourselves in scarfs and overcoats and enjoy the changing seasons. Meanwhile animals start thinking about the issues of survival, because the beginning of the cold part of the year means that available resources will be scarce again. But how do animals actually adapt to seasons? […]

Scientists from Trinity have discovered a new link between impaired brain energy metabolism and delirium – a disorienting and distressing disorder particularly common in the elderly and one that is currently occurring in a large proportion of patients hospitalised with COVID-19. While much of the research was conducted in mice, […]

Every time you flex your bicep or stretch your calf muscle, you put your cells under stress. Every move we make throughout the day causes our cells to stretch and deform. But this cellular deformation can be dangerous, and could potentially lead to permanent damage to the DNA in our […]

Effective wound care requires the maintenance of optimal conditions for skin and tissue regeneration. Hydrogels provide many of these conditions, but not an alkaline environment. Now, in a breakthrough study, scientists at Tokyo University of Science, Japan, have developed a new method that requires no specialized equipment and can be […]

Researchers at James Cook University and La Trobe University are working on making life better for people with Parkinson’s disease by developing a new exercise program. Moira Smith, lecturer in physiotherapy at JCU, said Parkinson’s disease is a progressive neurological condition affecting the ability to control movement. “People with Parkinson’s […]

In a development that may finally offer hope to children with Dravet syndrome and their parents, a new promising investigational therapy appears to alter the destructive course of the deadly disease. Lori Isom, Ph.D., chair of the University of Michigan’s department of pharmacology and professor of molecular & integrative physiology and neurology […]

In one out of 100,000 infants, a mutation in the GALC gene causes an incurable, always fatal disorder known as infantile Krabbe disease, or globoid cell leukodystrophy. Most children with the condition die before they turn 2. A parallel condition also naturally affects dogs, who typically show symptoms of the […]

Study Reveals the Second X Chromosome Confers Protection. Women with Alzheimer’s live longer than men with the disease, and scientists at UC San Francisco now have evidence from research in both humans and mice that this is because they have genetic protection from the ravages of the disease. By virtue […]

A Phase 1 patient trial of the novel, oral therapy candidate, alpha-TEA, for advanced HER2 positive breast cancer is now underway.  Veana Therpeutics, Inc., and UW Medicine will collaborate on the clinical testing of Veana’s lead agent – an alpha TEA lysine salt, in combination with the monoclonal antibody, trastuzumab, brand name Herceptin. In HER2 positive […]

A new study finds women with diabetes and significant levels of calcium in their coronary arteries have higher rates of death from cardiovascular disease and all causes than their male counterparts. Published in the American Diabetes Association journal, Diabetes Care, researchers from the University of California, Irvine School of Medicine and Cedars-Sinai […]

Splitting one type of cancer drug in half and delivering the pieces separately to cancer cells could reduce life-threatening side effects and protect healthy, non-cancerous cells, a new study suggests. The study, published in the Proceedings of the National Academy of Sciences, suggests that splitting immunotoxins into two inactive and […]

Scientists at the University of Michigan have discovered a novel anti-aging defense in the brain cells of adult fruit flies: producing extra copies of the genome. The findings could help explain how the brain, which rarely produces new cells, is able to cope with the accumulation of cell damage over […]

Lawrence Livermore National Laboratory (LLNL) scientists have paired 3D-printed, living human brain vasculature with advanced computational flow simulations to better understand tumor cell attachment to blood vessels, the first step in secondary tumor formation during cancer metastasis. The unique approach, developed with outside collaborators, lays the foundation for developing a predictive […]

Collaborative Cancer Research UK-funded studies from University of Oxford researchers have uncovered a new mechanism by which cancer cells adapt to the stresses they encounter as they grow and respond to therapies. This mechanism involves cells releasing small vesicles, known as exosomes. These contain complex mixtures of proteins, RNAs and […]

COVID-19 didn’t make all other diseases disappear. Cancer is still killing people like before and scientists are still trying to find new ways to treat it. Now researchers from the University of Queensland found that fresh tumour biopsies respond differently to medicine than the  tissue cultures traditionally used. This could […]

Researchers from Macquarie University have discovered a world-first new treatment that reverses the effects of memory loss associated with Alzheimer’s disease in a study of mice with advanced dementia. The research, co-led by two brothers, Dr Arne Ittner and Professor Lars Ittner, from Macquarie University Dementia Research Centre, builds on their work […]