General

Senescent cells accumulate with age, causing tissue dysfunction throughout the body via their inflammatory secretions. One of those dysfunctions is the age-related imbalance in bone remodeling, favoring the osteoclasts that break down bone tissue at the expense of the osteoblasts that rebuild it. The result is osteoporosis, the characteristic loss […]

Researchers led by Osaka University explore the relationship between autophagy and metabolism during fasting. The coming of spring harkens spring cleaning; a time to de-clutter your home and discard things that are no longer needed. In the body, a cellular process called autophagy occurs regularly to “de-clutter” our cells. Recently, […]

Researchers from the Department of Ophthalmology at the University Hospital Bonn (UKB) and Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) have found a close connection between the dimensions of retinal structures and those of the brain. They report on this in the journal “Scientific Reports”. Their study results suggest that assessments […]

The first complete human reference genome, which can serve as a template for sequencing DNA, corrects errors in the previous reference such as missing or misplaced genetic code. Alongside the newly updated human genome, which fills in long-standing gaps to fully spell out the more than 3 billion letters that […]

Partial reprogramming exposes senescent cells to the Yamanaka factors for long enough to reset their epigenetic patterns to those of a youthful cell, but not so long as to force a change of state into induced pluripotent stem cells. This is an active area of research, not yet an exact […]