The team of biomedical researchers at the Center for Computational Imaging and Personalized Diagnostics (CCIPD) has tackled various aspects of lung cancer, breast cancer, colon cancer and more since the centre was launched at Case Western Reserve University in 2012 by bioengineering pioneer Anant Madabhushi.
Now, Madabhushi’s lab and partners in the Perelman School of Medicine at the University of Pennsylvania (Penn) and Cleveland Clinic, using Artificial Intelligence (AI)-driven precision medicine research, are applying those same techniques to look at which cardiac patients will be more likely to accept or reject a new heart.
Their team was recently awarded a four-year, $3.2 million National Institutes of Health (NIH) grant to pursue the project.
Cleveland Clinic, Penn, and Cedars-Sinai Medical Center will provide the data—digitized images of biopsies from patients who have already had transplants. Then, Madabhushi and Kenneth B. Margulies, MD, a professor of Cardiovascular Medicine at Penn, will apply the AI techniques to the data to see whether the initial biopsy images could have more accurately predicted which patients would accept or reject the new heart.
“Right now, the pathologists look at the biopsies and use their own rating scheme based on the features of the heart tissue,” said Madabhushi, the F. Alex Nason Professor II of Biomedical Engineering at Case Western Reserve. “What we’re doing, is applying the power of AI and computer vision to analyze the biopsy tissue images to quantitatively and reproducibly distinguish different cardiac rejection grades.”
Madabhushi and his team of researchers in the centre, which has become a global leader in AI-driven precision medicine research, now numbers more than 60 post-doctoral students, graduate students and undergraduates.
In case after case, they have successfully taught the AI computers to find variations among thousands of digitized images of various cancers—anomalies mostly unseen by the naked eye.
Those variations in cellular arrangement and appearance, when interpreted by algorithms developed by the researchers, have helped scientists in previous studies more accurately predict which patients will respond better to chemotherapy or immunotherapy, for example, or to identify differences in how cancer cells appear among racial groups, among other findings.
However, unlike labs conducting other AI deep-learning experiments—referred to as “black box” approaches by Madabhushi because the process for arriving at the answer is essentially hidden in the algorithm alone—the CCIPD has also focused on more interpretable features, he said.
That will be true in this study as well, Madabhushi said.
“The spatial architecture of myocytes and lymphocytes (both types of cardiac cells) in heart biopsies has been long recognized by pathologists as a hallmark of transplant rejection,” Madabhushi said.
He added that his lab’s work will help “translate this human-based interpretation of cellular architecture into quantitative statistics of the spatial interplay and the relative proximity of myocytes and lymphocytes with respect to each other.”
Research shows that the most significant risks of a heart transplant is the patient’s body rejecting the donor heart, in part because the body’s “immune system may see the donor heart as a foreign object and try to reject it, which can damage the heart.”
Those rejections account for about 10% of all deaths within the first three years after transplantation, according to the National Center for Biotechnology Information, a division of the NIH.
So, knowing in advance the likelihood of rejection would make a big difference for pathologists and surgeons, Madabhushi said.
Additionally, the researchers plan to:
Source: Case Western Reserve University