Conservation of resources is hardwired into the genetic code – Innovita Research

Conservation of resources is hardwired into the genetic code

When David Zeevi and Liat Shenhav began analyzing the genomes of marine microbes, their goal was to find biological tools to combat plastic pollution in the ocean. But in the course of their study, a curious observation led them to discover something much more universal: an aspect of evolution that may have shaped everything from slime moulds to humans.

Their research reveals that the genetic code—a set of rules by which DNA is translated into amino acids, and genes into proteins—inherently allows organisms to evolve without consuming too much carbon or nitrogen, key nutrients for building proteins. “The very structure of the code promotes conservation of resources,” says Zeevi, who like Shenhav is a fellow in The Center for Studies in Physics and Biology at Rockefeller. “And this is not only happening in microbes in the ocean but is ingrained in all of life.”

3D renderings of diatoms. Image credit: pxhere.com, CC0 Public Domain

The findings, published in Science, also provide new clues about the earliest stages of life on Earth, suggesting that the first biomolecules arose in an environment where carbon and nitrogen were scarce.

Universal patterns

Shenhav and Zeevi are studying microorganisms living in highly polluted waters hoping to identify those capable of eating plastic. Their initial approach was to search for microbial genes that look very similar among these organisms since evolution preserves genetic sequences that are crucial for a species’ survival in a given environment.

Soon, however, they found a whole lot of conserved genes that seemed to have nothing to do with surviving plastic pollution. And as they dug deeper, they saw a surprising pattern: depending on where the microbes lived, many of their genes didn’t tolerate changes that increased nutrient consumption.

In nitrogen-poor regions near the surface of the ocean, microbes showed fewer mutations that caused the addition of that limited nutrient into protein sequences, while those dwelling in deeper, carbon-poor regions tended to instead avoid the use of carbon. “That led us to wonder whether there’s something about the structure of the genetic code that offers this ability by generally promoting an economical use of resources,” Shenhav says.

The genetic code is composed of codons—triplets of DNA bases like CCA or CGA—each specifying a single amino acid that goes into a protein. A mutation in a codon can change the nutrient requirements for the new amino acid. The researchers simulated one million imaginary genetic codes composed of randomized codons. Comparing the real genetic code to the hypothetical ones, they found that overall, the nutrient cost of possible mutations to the genome is much lower than what would be expected if the genetic code was set at random.

Similar calculations revealed the same relationship between genetic sequence and nutrient cost in 39 organisms across all domains of life, from plants to humans.

“Mutations still occur, but thanks to our particular genetic code, they are less likely to require more carbon and nitrogen,” Shenhav says. “The genetic code is like a buffer, protecting us from needing more resources.”

As for the researchers’ search for plastic-eating microbes, the new findings will be helpful, she says. “Now that we understand these properties of the code itself, we can account for them in our models and better disentangle what genetic change comes from nutrient conservation and what is a response to pollution.”

Source: Rockefeller University