Older people are at increased risk of acute respiratory viral infections including SARS-COV-2, the virus that causes COVID-19, and influenza virus. There is an urgent need to identify novel therapeutics to improve outcomes during acute respiratory viral infections with aging.
Laboratory mouse. Image credit: Rama via Wikimedia, CC-BY-SA-2.0-FR
In a study published in the journal JCI Insight, William Kelley, M.D., Daniel Goldstein, M.D., and their colleagues from the University of Michigan and on COUR Pharm Inc., employed a mouse model of influenza viral infection to determine whether a proprietary nanoparticle improves outcomes to infection in aged mice.
Prior studies have shown that the nanoparticles used in the study have beneficial effects by preventing damaging immune cells, specifically monocytes, from entering sites of inflammation. Yet the efficacy of these nanoparticles in improving outcomes of viral infection with aging has not been determined previously.
The team used a murine model in which aged mice are highly susceptible to influenza infection. Importantly, as most humans present to clinics after influenza infection, they administered the nanoparticles to aged mice at day three post-infection, when the inflammatory response to the infection was well underway.
Kelly and colleagues found that the nanoparticles improved outcomes of influenza infection in aged mice, specifically improving blood oxygenation, reducing lung damage and other clinical outcomes. These clinical findings were associated with a reduced number of tissue-damaging inflammatory monocytes in the lungs of aged mice during infection.
“If these findings can be translated to humans, it could represent a novel therapy to improve outcomes in older people infected with acute respiratory viruses,” said Goldstein.