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An arthritis drug is to be trialed as a treatment for children with a fatal metabolic disorder which causes neurological deterioration thanks to the University of Manchester researchers. Sanfilippo syndrome is a rare genetic disease with devastating effects on the central nervous system which affects around 1 in 70,000 children, […]

Knowledge of how human fat tissue is affected by age has long been defined by numerous mouse-based studies. Researchers at Karolinska Institutet in Sweden have now, for the first time, been able to conduct a prospective study on humans that provides novel insights into how our fat cells reduce lipid […]

Most of us know that feeling of trying to retrieve a memory that does not come right away. You might be watching a romantic comedy featuring that famous character actor who always plays the best friend and finds yourself unable to recall her name (it's Judy Greer). While memory retrieval […]

The evidence to date strongly suggests that environmental factors determine longevity for the vast majority of people. If there are significant longevity-affecting gene variants out there, then they have small and unreliable effects (APOE), or are restricted to tiny lineages (SERPINE1), or both. The overwhelming majority of contributions to longevity […]

T cells of the adaptive immune system collectively become less functional with age. The immune system as a whole becomes more inflammatory and less effectively, a state described by the terms inflammaging and immunosenescence. Researchers here note that T cells struggle to survive in the aged environment, and are as […]

In today's open access research, the authors report on the generation of a biomarker of aging from the study of proteins secreted by senescent cells. Low cost assays that map closely to biological age, the burden of damage, are a potentially useful tool for research and development of rejuvenation therapies. […]

Chimeric antigen receptor (CAR) T cell therapies target specific surface features on other cells by providing T cells with a way to recognize that feature – the CAR. T cells so equipped will selectively destroy other cells with the target surface feature. To produce a CAR T cell therapy, a […]

In a new study, a computer algorithm improved the accuracy and efficiency of cervical cancer screening compared with cytology (Pap test), the current standard for follow-up of women who test positive with primary human papillomavirus (HPV) screening. The new approach uses artificial intelligence (AI) to automate dual-stain evaluation and has […]

University of Alberta engineering researchers have characterized the potentially hazardous particles in cannabis smoke and have raised awareness about their potential health effects. “It's not out of line to say there's a potential health risk in marijuana smoke, and there's not nearly enough research,” said Robert Nishida, a U of […]

Heart muscle cells made from stem cells could be used to screen drugs or develop cell-based therapies for heart disease. But these cells, called cardiomyocytes, are often immature, disorganized, and unable to behave together like working muscle tissue. University of Wisconsin–Madison researchers have created a new way to study how […]

PNNL proteomics researchers are part of a large consortium tracing the benefits of exercise on an unprecedented scale Exercise helps our bodies and minds. It is a common prescription to build strength and help slow heart disease, diabetes, anxiety, and depression. But how does exercise change the molecular makeup of […]

NineSigma, representing a Japanese pharmaceutical company with an expertise in bone-related diseases as one of their future focal areas, seeks a potential collaboration partner(s) that possess drug discovery seeds or molecular targets for rare diseases involving bones and growth plate cartilage. Through collaboration with a potential partner(s), the client ultimately aims to […]

By applying unsupervised and automated machine learning techniques to the analysis of millions of cancer cells, Rebecca Ihrie and Jonathan Irish, both associate professors of cell and developmental biology, have identified new cancer cell types in brain tumors. Machine learning is a series of computer algorithms that can identify patterns within enormous quantities […]

National Institutes of Health investigators and colleagues have discovered that when the immune system first responds to infectious agents such as viruses or bacteria, a natural brake on the response prevents overactivation. Their new study in mBio describes this brake and the way pathogens such as SARS-CoV-2, the virus that causes […]

Princeton researchers have created a device that can herd groups of cells like sheep, precisely directing the cells’ movements by manipulating electric fields to mimic those found in the body during healing. The technique opens new possibilities for tissue engineering, including approaches to promote wound healing, repair blood vessels, or […]

The role genetics and gut bacteria play in human health has long been a fruitful source of scientific enquiry, but new research marks a significant step forward in unraveling this complex relationship. Its findings could transform our understanding and treatment of all manner of common diseases, including obesity, irritable bowel […]

In a study in mice, researchers at Karolinska Institutet have discovered a new potential therapeutic approach to facilitate neurological recovery in people with diabetes suffering from a stroke. The treatment strategy is based on the chronic normalization of hyperglycemia after stroke. The scientists hope that these new results, presented in […]

As COVID-19 restrictions loosen this summer, Canadians will spend more time outdoors and make the most of the sunshine. A new study from McGill University suggests why men may be more genetically prone to develop skin cancer. The research led by Professor Ian Watson of McGill’s Goodman Cancer Research Centre […]

An international research team led by Dr. Tali Ilovitsh of the Biomedical Engineering Department at TAU developed a noninvasive technology platform for gene delivery into breast cancer cells. The technique combines ultrasound with tumor-targeted microbubbles. Once the ultrasound is activated, the microbubbles explode like smart and targeted warheads, creating holes in cancer cells' […]

The expansion of the human brain during evolution, specifically of the neocortex, is linked to our cognitive abilities such as reasoning and language. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden have been studying a gene called ARHGAP11B for many years. This gene […]

A new method of analysing cancer patients’ blood for evidence of the disease could be up to ten times more sensitive than previous methods according to new research led by the University of Cambridge. In the coming years, this method and others based on this approach could lead to tests […]

Chemical engineers from the USC Viterbi School of Engineering have unlocked a fatal vulnerability in many cancer cells—sugar inflexibility. Like any cells in the body, cancer cells need sugar ­– namely glucose – to fuel cell proliferation and growth. Cancer cells in particular metabolize glucose at a much higher rate […]

New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells — including cancer cells — regulate their genes. The enzyme, LSD1, can “turn off” gene expression by removing chemical flags (methyl groups) from the nucleosome — tightly packed units of […]

One woman shares her experience with the Ross procedure, an aortic valve replacement surgery performed by only a few cardiac surgeons in the country. As a teacher at Madonna University in Livonia, Michigan, Anne McLeod, R.N., D.N.P., was able to let her nursing students hear the sound of a heart […]

A major U.S. study reveals large gaps between urban and rural patients in quality of care received after a stroke and rates of survival. In more rural areas, the ability of hospitals to deliver advanced stroke care is lower and mortality rates substantially higher, the research shows. The analysis, involving […]

The results of this work are presented in the medical journal Blood Advances published by the American Society of Hematology. Routine neonatal screening, although not yet available in Quebec, has led to an increase in the incidence of patients diagnosed with SCID in North America in recent years. This syndrome, a […]

The Recombinant Antibody Network (RAN), a consortium comprising research groups from UC San Francisco, the University of Chicago, and the University of Toronto, has entered into a second research collaboration with Celgene that aims to create and develop high-performance recombinant antibodies against diverse targets in human cells. The first RAN collaboration […]

Yale clinicians report promising results after treating COVID-19 patients at Yale-New Haven Hospital (YNHH) with a drug that reduces hyper inflammation in cancer patients undergoing immunotherapy. The team initially gave the drug, tocilizumab, to the most severely ill COVID-19 patients — specifically, those experiencing a dangerous immune response known as […]

Metastasis accounts for approximately 90 percent of mortality in breast cancer patients. During the last few decades, there has been significant progress in understanding genetic, molecular and signaling mechanisms underpinning cancer cell migration. Biologists from Lawrence Livermore National Laboratory (LLNL) found another mechanism that affects the maintenance and expansion of malignant cells: […]

Having bad teeth hurts your mouth, blood vessels and blood itself, and even your brain. Many people have fear of dentists. But did you know there are dentists for phobic patients too? Visiting an oral health specialist may also have another – often hidden but positive consequence – a potential […]