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A Canadian research team has uncovered a new mechanism involved in Bourneville tuberous sclerosis (BTS), a genetic disease of childhood. The team hypothesizes that a mutation in the TSC1 gene causes neurodevelopmental disorders that develop in conjunction with the disease. Seen in one in 6,000 children, tuberous sclerosis causes benign […]

Researchers at UC San Francisco have found that extreme caloric restriction diets alter the microbiome in ways that could help with weight loss but might also result in an increased population of Clostridioides difficile, a pathogenic bacterium that can lead to severe diarrhoea and colitis. Such diets, which allow people only […]

Bone cancer is hard to treat and prone to metastasis. Research teams at Rice University and Baylor College of Medicine have a new strategy to attack it. Chemist Han Xiao at Rice and biologist Xiang Zhang at Baylor and their labs have developed an antibody conjugate called BonTarg that delivers drugs to bone tumors and inhibits […]

Each day the average human heart beats 100,000 times and pumps about 2,000 gallons of blood. It’s a process that is critical to life, and yet it often goes awry for unknown reasons.   “Despite knowing a lot about muscle contraction and the heart, in particular, there are still a number of questions scientists have […]

A new art/science collaboration uses molecular structures as its creative medium. In Jenna Sutela’s work, which ranges from computational poetry to experimental music to installations and performance, the MIT Center for Art, Science & Technology (CAST) Visiting Artist enlists microbes and neural networks as co-creators. “I want to explore this notion […]

PhD student Sarah Nyquist applies computational methods to understudied areas of reproductive health, such as the cellular composition of breast milk. Sarah Nyquist got her first introduction to biology during high school, when she took an online MIT course taught by genomics pioneer Eric Lander. Initially unsure what to expect, […]

A University of Texas at Arlington researcher is examining how historic segregation in the United States may contribute to cardiovascular disease among individuals from minority or low-income groups. “If this research does find neighborhood factors, like racial segregation and income, impact cardiovascular disease in minority and low-income people, then we […]

Blood-brain barrier typically protects the brain, but is also quite a bit of a challenge for scientists trying to create therapies for neurological conditions. Drugs that should act on the brain struggle to pass this barrier. Now scientists at The University of Queensland have found that an ultrasound therapy could […]

New research has found that previous infection, whether it was symptomatic or asymptomatic, does not necessarily protect you long-term from COVID-19, particularly against new Variants of Concern. The preprint study was led by the University of Oxford, in collaboration with the Universities of Liverpool, Sheffield, Newcastle and Birmingham with support […]

An investigational Alzheimer’s drug reduced molecular markers of disease and curbed neurodegeneration in the brain, without demonstrating evidence of cognitive benefit, in a phase 2/3 clinical trial led by researchers at Washington University School of Medicine in St. Louis through its Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU). These results led the trial […]

By the time people with Alzheimer’s disease start exhibiting difficulty remembering and thinking, the disease has been developing in their brains for two decades or more, and their brain tissue already has sustained damage. As the disease progresses, the damage accumulates, and their symptoms worsen. Researchers at Washington University School […]

Thanks to researchers in different fields who put in nearly two decades of past work on mRNA vaccine technology, people around the world are being immunized today from COVID-19 — and hopefully leading us out of this pandemic. Now, because of the increased focus on this versatile technology and that foundation […]

Her first intervention was at the dawn of open-heart surgery. This month she got a newly available pulmonary valve, placed with a tiny incision. In 1958, Susie Knudsen became a 12-year-old trailblazer as one of the first children anywhere to undergo open-heart surgery.  After she suffered a heart attack in […]

Middle schoolers who spend time on smartphones, laptops and tablets in the hour before bed are likely to sleep poorly and be more tired the next day, leading them to use media devices at bedtime even more. Those are among the findings of a study published by the National Sleep Foundation by […]

Rice University bioengineers collaborated on a six-year study that systematically analyzed how the surface architecture of breast implants influences the development of adverse effects, including an unusual type of lymphoma. Every year, about 400,000 people receive silicone breast implants in the United States. According to FDA data, most of those […]

How do you kill tumor cells that can’t be targeted? Get their more susceptible neighbors to help. The Rice University lab of synthetic chemist K.C. Nicolaou, in collaboration with AbbVie Inc., has created unique antibody-drug conjugates (ADCs) that link a synthetic uncialamycin analogue to antibodies that target cancer cells. Once they enter the […]

Communities surrounding the Salton Sea, the inland body of water straddling California’s Riverside and Imperial counties, show high rates of asthma due, possibly, to high aerosol dust levels resulting from the sea shrinking over time. Scientists suspect, however, the Salton Sea plays an additional role in pulmonary health. A University […]

Adolescents who stopped studying maths exhibited greater disadvantage – compared with peers who continued studying maths – in terms of brain and cognitive development, according to a new study published in the Proceedings of the National Academy of Sciences. 133 students between the ages of 14-18 took part in an […]

A team of University of Oxford researchers, funded by the British Heart Foundation, have identified an entirely new risk factor for congenital heart disease (CHD). Using an animal model system, researchers have shown that if the mother is severely iron deficient and anaemic during early pregnancy, this greatly increases the […]

A new study led by the Nuffield Department of Population Health at the University of Oxford will research whether a daily tablet could help protect the millions of people worldwide with type 2 diabetes from developing cardiovascular disease. Cardiovascular disease is the leading global killer, causing approximately 18 million deaths […]

Women who will develop potentially life-threatening disorders during pregnancy can be identified early when hormone levels in the placenta are tested, a new study has shown. Nearly all of the organ systems of the mother’s body need to alter their function during pregnancy so that the baby can grow. If […]

Scientists have identified key molecular events in the developing human embryo between days 7 and 14 – one of the most mysterious, yet critical, stages of our development. The second week of gestation represents a critical stage of embryo development, or embryogenesis. Failure of development during this time is one of the […]

Researchers have shown why people with mental health disorders, including anorexia and panic disorders, experience physical signals differently. The researchers, from the University of Cambridge, found that the part of the brain which interprets physical signals from the body behaves differently in people with a range of mental health disorders, […]

Scientists working to understand the cellular processes linking high cholesterol to breast cancer recurrence and metastasis report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles. Reported in the journal Endocrinology, the […]

Canine parvovirus (CPV) is a highly infectious pathogen that causes severe diseases in unvaccinated dogs, including inflammation of the heart and acute gastrointestinal illness. Originating in cats, the virus is a rare example of a DNA-based virus that can jump between species, and a team of researchers’ discovery may help […]

A clinical study has investigated whether immunotherapy against type 1 diabetes can preserve the body’s own production of insulin. The results suggest that injection of a protein, GAD, into lymph nodes can be effective in a subgroup of individuals. In type 1 diabetes, the body’s immune system attacks the cells […]

A study, led by Greater Manchester Mental Health NHS Foundation Trust (GMMH) and The University of Manchester (UoM), and funded by the National Institute for Healthcare Research (NIHR), has found that a mental health treatment called Metacognitive Therapy significantly improves symptoms of anxiety and depression for heart disease patients. These […]

Implant surface topography can influence the development of scarring, inflammation, and other complications, researchers find. Every year, about 400,000 people receive silicone breast implants in the United States. According to data from the U.S. Food and Drug Administration, a majority of those implants needs to be replaced within 10 years […]

Leukemia stem cells are rare cells that can renew themselves while continuing to generate malignant cells known as leukemic blasts. These cells are difficult to eradicate using chemotherapy drugs and frequently lead to recurrence of leukemia. Leukemia stem cells, however, are dependent on a protein complex called polycomb repressive complex […]

Scientists studied the brain activity of school-aged children during development and found that regions that activated upon seeing limbs (hands, legs, etc.) subsequently activated upon seeing faces or words when the children grew older. The research, by scientists at Stanford University, Palo Alto, California, reveals new insights about vision development […]