February 7, 2018

Active Genetics Technology Opens New Horizons

In 2015, University of California San Diego biologists Ethan Bier and Valentino Gantz developed a breakthrough technology known as “active genetics,” which results in parents transmitting a genetic trait to most of their offspring (instead of 50 percent receiving the trait under standard inheritance). Immediate targets of active genetics included gene-drive systems […]
February 7, 2018

Scientists discover off-switch for ‘molecular machine’ active in many diseases

A discovery by Queensland scientists could be the key to stopping damage caused by uncontrolled inflammation in a range of common diseases including liver disease, Alzheimer’s and gout. University of Queensland researchers have uncovered how an inflammation process automatically switches off in healthy cells, and are now investigating ways to stop […]
February 6, 2018

Study reveals how the most common DNA mutation happens

In the issue of the journal Nature, researchers describe how two normally mismatched bases in human DNA, guanine and thymine, are able to change shape in order to form an inconspicuous rung on the helical DNA “ladder.” This allows them to survive by avoiding the body’s natural defenses against genetic mutations. […]
February 6, 2018

In-Person License Renewal, not Physician Reporting, Associated with Fewer Crash Hospitalizations Among Drivers with Dementia

Requiring physicians to report patients with dementia to state driver’s licensing authorities is not associated with fewer hospitalizations from motor vehicle crashes. However, in-person license renewal laws and vision testing dramatically cut crashes involving drivers with dementia, according to a new study led by the University of Pittsburgh Graduate School of […]
February 6, 2018

Oestrogen causes neuroblastoma cells to mature into neurons

Neuroblastoma forms in the peripheral nervous system and is one of the most common forms of solid cancer in young children. The disease mainly affects babies and young children, and while in some cases the tumours can disappear of their own accord, the majority are aggressive, metastasising cancer tumours that […]
February 6, 2018

Fertility Study Offers Unexpected Lead on Dwarfism

As components of two entirely separate systems in the body, you wouldn’t think ovaries have much in common with bones. But it turns out they do – and their commonalities may help explain why dwarfs such as actors Peter Dinklage and David Rappaport are so short, say UConn Health scientists. […]
February 6, 2018

Scientists report big improvements in HIV vaccine production

Research on HIV over the past decade has led to many promising ideas for vaccines to prevent infection by the AIDS virus, but very few candidate vaccines have been tested in clinical trials. One reason for this is the technical difficulty of manufacturing vaccines based on the envelope proteins of […]
February 5, 2018

U-M discovery helps build a better target for anticancer drug discovery

In one of many ways cancer attacks the body, it activates an enzyme that is typically absent in normal, healthy cells. The enzyme is also present in stem cells. When stem cells in our bodies divide, chromosomes within those cells, which carry our genetic material, shorten. If they become too […]
February 5, 2018

Chemistry breakthroughs open new doors to drug developers and cancer researchers

Two independent chemistry breakthroughs have opened a plethora of doors that were previously locked to drug developers and cancer researchers. The discoveries, which involved adding new materials to a previously unstable chemical scaffold and building molecules onto the “pigments of life”, will also offer new possibilities to molecular engineers, materials […]
February 2, 2018

Uncovering the early origins of Huntington's disease

With new findings, scientists may be poised to break a long impasse in research on Huntington’s disease, a fatal hereditary disorder for which there is currently no treatment. One in 10,000 Americans suffer from the disease, and most begin to show symptoms in middle age as they develop jerky movements—and […]
February 2, 2018

New tool for tracking “kiss-and-run” communication between cells could advance research in multiple fields

A new method for monitoring interactions between cells, dubbed LIPSTIC by its creators, is much more than a cosmetic improvement over existing techniques. The breakthrough, led by The Rockefeller University assistant professor Gabriel Victora, offers scientists in a wide range of disciplines a powerful new tool for studying complex biological events […]
February 2, 2018

Researchers Invent Reversible 'Off-Switch' for Cellular Proteins

UC San Francisco scientists have invented a technique that lets them precisely and reversibly disrupt the action of specific cellular proteins at a microscopic scale by making them split apart when illuminated with blue light. The researchers envision a vast number of applications for the technique in the study of […]
123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384858687888990919293949596979899100101102103104105106107108109110111112113114115116117118119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263264265266267268269270271272273274275276277278279280281282283284285286287288289290291292293294295296297298299300301302303304305306307308309310311312313314315316317318319320321322323324325326327328329330331332333334335336337338339340341342343344345346347348349350351352353354355356357358359360361362363364365366367368369370371372373374375376377378379380381382383384385386387388389390391392393394395396397398399400401402403404405406407408409410411412413414415416417418419420421422423424425426427428429430431432433434435436437438439440441442443444445446447448449450451452453454455456457458459460461462463464465466467468469470471472473474475476477478479480481482483484485486487488489490491492493494495496497498499500501502503504505506507508509510511512513514515516517518519520521522523524525526527528529530531532533534535536537538539540541542543544545546547548549550551552553554555556557558559560561562563564565566567568569570571572573574575576577578579580581582583584585586587588589590591592593594595596597598599600601602603604605606607608609610611612613614615616617618619620621622623624625626627628629630631632633634635636637638639640641642643644645646647648649650651652653654655656657658659660661662663664665666667668669670671672673674675676677678679680681682683684685686687688689690691692693694695696697698699700701702703704705706707708709710711712713714715716717718719720721722723724725726727728729730731732733734735736737738739740741742743744745746747748749750751752753754755756757758759760761762763764765766767768769770771772773774775776777778779780781782783784785786