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A new multi-institution, dose-determining clinical trial of a compound against metastatic, castration-resistant prostate cancer showed promising results, researchers reported in Clinical Cancer Research. The phase 1b/2a study of the pan-BET bromodomain inhibitor ZEN-3694 in combination with enzalutamide was led by researchers at the University of Michigan Rogel Cancer Center, the University of California, San Francisco, […]

Enzalutamide is one of the main treatments for patients with metastatic, castration-resistant prostate cancer — the lethal form of the disease. However, treatment options are limited for those who develop resistance to enzalutamide. Now, a multi-institution team has uncovered new clues that may help overcome resistance in some patients, according […]

The Encyclopedia of DNA Elements (ENCODE) Project(link is external) is a worldwide effort to understand how the human genome functions. With the completion of its latest phase, the ENCODE Project has added millions of candidate DNA “switches” from the human and mouse genomes that appear to regulate when and where genes are […]

Two decades or more before symptoms arise, plaques of a sticky protein called amyloid to begin forming in the brains of people later diagnosed with Alzheimer’s disease. Researchers at Washington University School of Medicine in St. Louis have shown that levels of a specific protein in the blood rise as […]

Florida State University Professor of Biological Science David Gilbert is using the latest information about the human genome as a guide to better understand cancer. Gilbert and his FSU colleagues were part of a team that compared different cancer cell types to a database of normal human cells using a […]

The molecular chaperone protein known as heat shock protein 90 (Hsp90) helps stabilize a number of proteins that are involved in tumor growth. This is why inhibitors that act on the protein have been investigated as potential anti-cancer drugs. So far, however, the inhibitors developed by various academic groups and […]

When we get a wound on our skin, the cells in our bodies quickly mobilize to repair it. While it has been known how cells heal wounds and how scars form, a team led by researchers from Washington University in St. Louis has determined for the first time how the […]

Many children treated for childhood malnutrition in developing countries never fully recover. They suffer from stunted growth, immune system dysfunction and poor cognitive development that typically cause long-term health issues into adulthood. Now, new research from Washington University School of Medicine in St. Louis and the International Centre for Diarrhoeal […]

Alone genetic mutation can cause a life-changing disorder with effects on multiple body systems. Lysosomal storage diseases, for example, of which there are dozens, arise due to single mutations that affect the production of critical enzymes required to metabolize large molecules in cells. These disorders affect multiple organs including, notably, […]

A new comparison of two breast-screening technologies has found that, for most women, digital breast tomosynthesis (DBT, also called 3D mammography) is superior to digital mammography for cancer detection and for reducing recall visits due to unclear or false findings. The study’s distinction, though, is in identifying women for whom […]

New findings by chemists Wolfgang Peti and Rebecca Page provide a foundation to better understand and treat these neurological disorders. From the movement of a finger to the creation of a memory, actions of the human body require the harmonious concert of protein interactions. A system of checks and balances […]

https://www.sciencedirect.com/science/article/pii/S2213671120302411A team of British and American scientists have discovered a way to slow the growth of breast cancer stem cells in the lab. The study led by Dr Bruno Simões and Professor Rob Clarke from The University of Manchester could eventually lead to combination drug therapies on previously untreatable breast […]