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Immunotherapy as a treatment for advanced solid organ tumors has rapidly evolved over the past decade, often yielding remarkable results. However, its use has also given way to new adverse effects, including drug-induced gastrointestinal and liver toxicities. “Checkpoint inhibitors are a game changer for a lot of oncology patients with […]

You definitely have smelled it before, Whether it’s your grandparents or complete strangers, old people have a very specific smell. Some people describe it as musty, others – as stale of even medical. But what causes it? And why so many older people smell so alike? Well, part of the […]

How often do you leave notes for yourself on your phone? Most people do it almost every day. It is very convenient – we write something down and our phones remind us about it whenever we set them to. But how this habit affects your memory? Scientists from the University […]

Time is not good for us. As we age, condition of our bodies start to decline right to the cellular level. A lot of the age-related gastrointestinal problems can be traced to ageing cells of the intestinal epithelium. But now scientists from the University of Helsinki and Karolinska Institutet found […]

Feverfew is a common flowering garden plant. It has small flowers and looks rather lovely, but it is also used as medicine. In fact, it is sold in health food shops as a remedy for migraine and other aches and pains. Now scientists from the University of Birmingham were able […]

Invisible illness – this is how various mental conditions are sometimes described. For example, you cannot really see dementia. Or can you? Scientists from the University of Queensland used super-resolution microscopy to see key molecules in living brain cells. This may help understanding memory formation and the mechanisms of dementia. […]

Researchers at the Stanford University School of Medicine have discovered a new signal that cancers seem to use to evade detection and destruction by the immune system. The scientists have shown that blocking this signal in mice implanted with human cancers allows immune cells to attack the cancers. Blocking other “don’t eat […]

Most multicellular organisms on Earth—including you—begin as a single fertilized egg and then undergo a complex choreography of cellular growth to become a functioning adult composed of countless cells. Understanding this process is a major goal in the field of developmental biology. Now, using the fruit fly Drosophila melanogaster as a model […]

Hormone replacement therapy is a common treatment for menopause-related symptoms, and new research from the University of Pittsburgh Graduate School of Public Health reinforces the importance of tailoring hormone therapy to each patient, based on her individual risk factors for cardiovascular disease. In a study published in the Journal of the American […]

Researchers have found that anti-inflammatory biologic therapies used to treat moderate to severe psoriasis can significantly reduce coronary inflammation in patients with the chronic skin condition. Scientists said the findings are particularly notable because of the use of a novel imaging biomarker, the perivascular fat attenuation index (FAI), that was […]

A fundamental research study on microRNAs, tiny molecules that help control gene activity inside plants and animals, has made an unexpected connection to a molecule associated with multiple genetic diseases. Researchers at the Institute for Quantitative Biosciences discovered that a protein, VCP, known for its involvement in neurodegenerative diseases also […]

Moving to a new residence during the first three months of pregnancy is linked to a heightened risk of premature birth and low birthweight, as well as a slightly higher risk of a smaller-than-expected-size baby, according to new research from the University of Washington published online in the Journal of […]

We expect quality from our healthcare systems and institutions. We need to be sure that we are getting services of the highest order and we want consistency. However, we are certainly not getting it. Scientists from the University of Adelaide and Flinders University found that cardiac device complications vary widely […]

It is difficult to comprehend how many people are dealing with chronic pain every day. Studies have shown that 30 % of people involved in motor vehicle accidents will go on to develop a chronic pain. And then there are people with all kinds of conditions, injuries and illnesses causing […]

A large-scale, collaborative, systems biology approach is needed to expedite the discovery of treatments for dry age-related macular degeneration (AMD) – a leading cause of blindness among people 65 and older for which is there is no treatment— according to a report by a working group of scientists appointed by […]

A University of Saskatchewan medical research team will receive $987,000 from Western Economic Diversification (WD) towards a $4.55-million project aimed at producing and testing new imaging agents for diagnosing lung and colorectal cancers in humans. The federal investment will enable clinical development of first-of-their-kind imaging agents for molecular, non-invasive diagnosis […]

An antibody-drug conjugate (ADC) is comprised of an antibody connected to a cytotoxic agent with a linker. ADCs are designed to selectively target tumors via binding to specific markers found on the cell surface. Although many ADCs are in clinical development, only a few are FDA approved. To improve the […]

Weight loss can be difficult, but could intermittent fasting help? This eating pattern, which features cycles of fasting and eating, is making headlines as research confirms it’s not only what you eat, but when you eat, that matters in the struggle to lose weight. During intermittent fasting, individuals use specific periods of eating — […]

New research has found that a rare blood cancer can be simulated in the lab only by simultaneously infecting white blood cells with two viruses typically found in the tumors. The successful creation of stable, cancer-like cells in the lab opens up opportunities for understanding the progression of this and […]

Dexamethasone, a synthetic glucocorticoid, may be more effective in protecting the auditory system when delivered during the active phase. A novel study shows how the time of the day impacts on the treatment outcome. The study is published in Current Biology and has been conducted by researchers at Karolinska Institutet. […]

Scientist have identified a link between exposure to high levels of oestrogen sex hormones in the womb and the likelihood of developing autism. The findings are published in the journal Molecular Psychiatry. The discovery adds further evidence to support the prenatal sex steroid theory of autism first proposed 20 years […]

Although psychiatric disorders can be linked to particular genes, the brain regions and mechanisms underlying particular disorders are not well-understood. Mutations or deletions of the SHANK3 gene are strongly associated with autism spectrum disorder (ASD) and a related rare disorder called Phelan-McDermid syndrome. Mice with SHANK3 mutations also display some […]

In recent decades, scientists have successfully mapped the human genome, but it’s viewed in a way similar to viewing a screen without a sharp resolution picture. Now a new digital tool designed at the University of Missouri will allow scientists to study the detailed interactions between chromosomes within the human genome through […]

As we age, our eyes lose their ability to focus up close. It’s a condition called presbyopia, and it’s both extremely common and relatively easy to fix, with solutions like reading glasses, bifocals, or progressive lenses. Another common correction, called monovision, solves the problem with different lenses in each eye, […]

A team of Vanderbilt investigators has discovered how a DNA repair pathway protein shields sites of damage to avoid mutations and maintain genome integrity. “DNA repair is critical to prevent cancer. The loss of or inefficiencies in DNA repair cause mutations and changes in our chromosomes that lead to cancer […]

Case Western Reserve University School of Medicine and University Hospitals (UH) Cleveland Medical Center have enrolled their first participant in a new clinical research study evaluating the potential benefits of an investigational medicine for people with early onset Alzheimer’s disease. The Phase 1 research study, called “Efavirenz in Patients with […]

In a study using yeast cells and data from cancer cell lines, Johns Hopkins University scientists report finding a potential weak spot in cancer cells that have extra sets of chromosomes, the structures that carry genetic material. The vulnerability is rooted in a common feature among cancer cells — the high protein […]

A researcher at The University of Texas at Arlington’s College of Nursing and Health Innovation will use a $634,000 National Institutes of Health grant to study the role of T cells in cardiovascular disease among older people. The five-year NIH grant awarded to Daniel Wayne Trott, an assistant professor in the Department […]

Argonne National Laboratory’s storied Advanced Photon Source, home to thousands of experiments through the years, is currently aiding in a study of shark spines — one that could shed light on human bones. The U.S. Department of Energy’s Advanced Photon Source (APS) at Argonne National Laboratory has facilitated tens of […]

Cuts, scrapes, blisters, burns, splinters, and punctures – there are a number of ways our skin can be broken. Most treatments for skin wounds involve simply placing a barrier over them (usually an adhesive gauze bandage) to keep it moist, limit pain, and reduce exposure to infectious microbes, but do […]