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A progressive decline in physical function, commonly referred to as functional decline, is a strong health determinant in older people. The accumulation of chronic diseases, multimorbidity, plays a major role in functional decline and has a negative impact on quality of life. Cardiovascular and neuropsychiatric diseases are common in older […]

When it comes to colorectal cancer, many people would benefit from individually tailored screening rather than standardized population guidelines. A new risk-prediction model, built by researchers at the University of Michigan and the Fred Hutchinson Cancer Research Center (Fred Hutch) in Seattle and colleagues, assesses the impact of environment and […]

A discovery sheds light on how cancerous cells differ from healthy ones, and could lead to the development of new strategies for therapeutic intervention for difficult-to-treat cancers in the future. An international team of investigators found a “stop sign”—a modified protein researchers named a PIP-stop—inside cells that are overused by […]

The absence of a protein critical to the control of inflammation may lead to rapid and severe bone loss, according to a new University at Buffalo study. The study found that when the gene needed to produce the protein tristetraprolin (TTP) is removed from healthy mice, the animals developed the […]

Bacteria found in the small intestines of mice and humans can travel to other organs and trigger an autoimmune response, according to a new Yale study. The researchers also found that the autoimmune reaction can be suppressed with an antibiotic or vaccine designed to target the bacteria, they said. The […]

An immunotherapy drug embedded in a slow-release hydrogel invented at Rice University in collaboration with the University of Texas Health Science Center at Houston (UTHealth) appears to be highly effective at killing cancer cells. STINGel combines a new class of immunotherapy drugs called stimulator of interferon gene (STING) agonists with an injectable hydrogel that […]

One of the liveliest debates in neuroscience over the past half century surrounds whether the human brain renews itself by producing new neurons throughout life, and whether it may be possible to rejuvenate the brain by boosting its innate regenerative capacity. Now UC San Francisco scientists have shown that in […]

As we get older, it’s not uncommon to experience “senior moments,” in which we forget where we parked our car or call our children by the wrong names. And we may wonder: Are these memory lapses a normal part of aging, or do they signal the early stages of a […]

After receiving a course of antiretroviral therapy for their HIV-like infection, approximately half of a group of monkeys infused with a broadly neutralizing antibody(link is external) to HIV combined with an immune stimulatory compound suppressed the virus for six months without additional treatment, according to scientists supported in part by the National […]

Death is not a single event. It is a series of events as life fades away. Part of it happens to be rigor mortis – a period of stiffness, which makes body somewhat rigid as muscles contract and joints lose flexibility. For humans it occurs after the main event of […]

Dramatic calorie restriction, diets reduced by 40 percent of a normal calorie total, have long been known to extend health span, the duration of disease-free aging, in animal studies, and even to extend life span in most animal species examined. Further research has shown that animals fed restricted-calorie diets are […]

Researchers from the University of Pennsylvania have developed a gene therapy that successfully treats a form of macular degeneration in a canine model. The work sets the stage for translating the findings into a human therapy for an inherited disease that results in a progressive loss of central vision and which is […]

Cancer arises when cells acquire errors (mutations) at certain locations in the DNA. These mutations are responsible for the characteristics of the cancer cells, and knowledge about the mutations present in a patient’s cancer is important for the diagnosis and treatment. A subset of these mutations may even be “druggable” […]

Older women residing in the U.S territories are less likely to receive recommended or timely care for breast cancer compared with similar women residing in the continental United States, according to Yale researchers. Their findings were published in the March issue of Health Affairs. Using Medicare claims data from 2008 to […]

In many organs, damaged tissue can be repaired by generating new cells of the type that were lost. However, after an injury to the central nervous system, a special type of scar tissue is formed which inhibits this regeneration. Injuries to the brain and spinal cord therefore often lead to […]

Team engineers protein to enhance T cells for fight against cancer cells UCLA engineers and scientists have engineered a type of synthetic protein — a chimeric antigen receptor, or CAR, that responds to soluble protein targets. The advance shows great promise for helping the body’s immune system seek out and […]

A new discovery about the immune system may allow doctors to treat harmful inflammation that damages the brain in neurodegenerative diseases such as Alzheimer’s. It might also let doctors save patients from the potentially deadly inflammation of sepsis, a full-body infection that kills a quarter-million Americans every year. The finding […]

Improving the trafficking of cellular proteins in brain cells holds possibilities for new treatments and even prevention for Alzheimer's disease, results of a new study suggest. Researchers found that a compound that enhances the shuttling of proteins within cells reduced the production of forerunners of two proteins implicated in brain […]

People with stage III colon cancer who regularly eat nuts are at significantly lower risk of cancer recurrence and mortality than those who don’t, according to a new, large study led by researchers at Yale Cancer Center. The findings were published in the Journal of Clinical Oncology. The study followed 826 […]

Her two-year study, begun with funding from Women’s Health Research at Yale in 2005, found that long-term treatment with the sex hormones estrogen and progesterone did not improve memory as anticipated. “It was surprising, because we thought for sure we’d see a benefit of at least some of our treatments,” […]

Breast cancer is the most common form of cancer in women. In Sweden, almost two thousand patients die of the disease every year. The fatalities are almost exclusively a consequence of tumours in the breast spreading to other organs, such as the skeleton, the brain and the liver. Metastases in […]

Our bodies are not just passively growing older. Cells and tissues continuously use information from our environments—and from each other—to actively coordinate the aging process. A new study from the University of Michigan Life Sciences Institute now reveals how some of that cross-talk between tissues occurs in a common model […]

Prenatal exposure to male hormones influences which activities girls are interested and engage in, but the effects of those hormones don’t extend to gender identity or who they socialize with, according to Penn State researchers. The researchers explored how prenatal exposure to androgens — hormones that are typically higher in […]

Brain tumors are among the deadliest forms of cancer, due in large part to their sensitive location and the challenge of performing surgery to remove them. New research led by David Solomon, MD, PhD, an assistant professor in the Department of Pathology at UC San Francisco, provides much-needed targeted treatment options for […]

Jesse Persily spent his summer chasing after answers to questions about one of the most deadly kinds of cancer. Persily, a fourth-year human biology major, received a Harrison Undergraduate Research Award last year to perform research on a specific subset of cancer patients. His work analyzed cell surface receptors on […]

DTU is opening a new Center of Excellence for Microbial Secondary Metabolites (CeMiSt), which aims to identify why microorganisms produce penicillin and other antibiotic substances, so-called secondary metabolites. The centre will be a training platform for a new generation of researchers, and the research will both pave the way for discovering fundamental biological principles […]

Science continues to peel away layers of the skin microbiome to reveal its protective properties. In a study published in Science Advances, University of California San Diego School of Medicine researchers report a potential new role for some bacteria on the skin: protecting against cancer. “We have identified a strain of Staphylococcus […]

The prospects – and consequences – of ageing are of concern to us all, especially when considering the likelihood of developing wrinkles. They are not only a hallmark of ageing but also play a fundamental role in how we physically interact with many products and devices, from moisturiser cream and […]

Artificial sweeteners are used in diet drinks and foods but also could someday be used as treatments targeting carbonic anhydrase IX (CA IX), a protein associated with aggressive cancers. Although several drugs have been approved that target similar forms of CA, they aren’t selective and may cause side effects, including […]

The cells, which were previously thought to be immobile, propel themselves forward toward wounds with a wormlike wave motion, rather than adhering to and pushing off from other structures like most motile cells do. University of Bristol Schools of Biochemistry, and Physiology & Pharmacology & Neuroscience Professor Paul Martin commented: […]