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An international team led by UNSW medical researchers has tested a chemical compound in the lab and a range of animal models to progress much-needed treatment options for neovascular age-related macular degeneration (AMD) and diabetic retinopathy (DR), the main eye complication of diabetes. While the preclinical studies provide hope to […]

Researchers from JCU’s Queensland Research Centre for Peripheral Vascular Disease, involving collaborators from across Queensland, are conducting clinical trials to investigate whether a new drug can be used for treating blocked leg artery-related walking impairment. “People with blocked leg arteries have a substantially reduced ability to walk, which leads to […]

The multicellular, 3-D structure of human pancreatic islets — the areas of the pancreas containing hormone-producing or endocrine cells — has presented challenges to researchers as they study and manipulate these cells’ function, but Vanderbilt University Medical Center researchers have now developed a pseudoislet system that allows for much easier […]

A protein linked to amyotrophic lateral sclerosis (ALS), a progressive neurological disease that causes muscle weakness, may be a key to treating fibrotic disease of the kidneys and other organs, researchers at Vanderbilt University Medical Center reported recently. FUS is the acronym of a protein in the nucleus of cells that regulates […]

Many modern cancer drugs target a specific genetic mutation that is driving particular cancer’s runaway growth and division — such as the HER-2 protein in some breast cancers or EGFR in certain lung cancers. But this strategy hasn’t worked well against glioblastoma, an aggressive form of brain cancer, which is […]

The findings from a recent study by a University at Buffalo researcher and others could prove to be a game-changer for men with Type 2 diabetes. The single-site study, conducted over 11 years in Bremerhaven, Germany, found that testosterone therapy reversed Type 2 diabetes in one-third of the study participants. […]

Scientists at the IRCM reveal the function of some 200 proteins previously unprobed by biologists, pointing the way to new therapeutic targets for cancers and neurological disorders. A team from the Montreal Clinical Research Institute (IRCM) has written a new chapter in gene regulation by unearthing the function of about […]

Best vitelliform macular degeneration, or Best disease, is an inherited eye condition that typically leads to blindness over the course of a few decades. The disease can be caused by more than two hundred mutations in the BEST1 gene. The researchers were able to correct the disease in stem cells from patients […]

More than 30 million Americans are infected with a brain parasite spread by cats and contaminated meat, but most will never show symptoms. A new discovery from the University of Virginia School of Medicine explains why, and that finding could have important implications for brain infections, neurodegenerative diseases, and autoimmune […]

Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation tools that could help fix genetic mutations responsible for hereditary diseases. Researchers at the University of California, Berkeley, have now obtained […]

T cells are the immune soldiers at the frontline of the battle with infiltrating pathogens that seek to cause disease. A new study published in Nature Biomedical Engineering describes a novel, label-free imaging technique that can differentiate active T cells from those off duty. The method produced by the U.S. National Science Foundation-funded research […]

Case Western Reserve University scientists are developing artificial intelligence (AI) tools to help surgeons and oncologists identify the subtle but critical differences between a recurring tumor and damaged non-cancerous tissue on post-operative MRI scans of certain cancer patients. The work is being led by Pallavi Tiwari, PhD, and Satish Viswanath, […]