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Changes in the gut microbiome have a role in aging, and the activities of microbial species (generation of beneficial metabolites, versus generation of harmful inflammation) may be as important as lifestyle choices such as exercise when it comes to the pace of aging. Certainly there is good evidence for rejuvenation […]

A new genome-wide CRISPR screening technique conducted by researchers at Vanderbilt University is offering new insights about how tumors in 80 to 90 percent of all cancers grow. This novel approach developed by Maria Fomicheva, a graduate student in the lab of Ian Macara, Louise B. McGavock Professor and professor of cell […]

Approximately two years after establishing a human cerebral organoid system to study Creutzfeldt-Jakob disease (CJD), National Institutes of Health researchers have further developed the model to screen drugs for potential CJD treatment. The scientists, from NIH’s National Institute of Allergy and Infectious Diseases (NIAID), describe their work in Scientific Reports. Human […]

Researchers have identified changes in the metabolism of liver and skeletal muscle cells in live mice that are likely connected to obesity-associated metabolic disorders. This study was led by Professor Shinya Kuroda, head of the Systems Biology Lab at the University of Tokyo and an expert in trans-omics research, which […]

Stopping smoking leads to healthier, wealthier and happier lives say researchers from University of Bath’s Addiction & Mental Health Group. New evidence published in the Cochrane Library suggests that smokers who quit can feel the positive benefits within weeks. The research, led by Dr Gemma Taylor from the University of Bath’s Addiction & […]

An interesting fact about the adaptive immune system: the number of T cells in the body remains much the same across the entire lifespan, even after the supply of new T cells all but ceases in middle age. T cells are created as thymocytes by hematopoietic cells in the bone […]

Delaying second doses of COVID-19 vaccines should reduce case numbers in the near term; however, the longer-term case burden and the potential for evolution of viral ‘escape’ from immunity will depend on the robustness of immune responses generated by natural infections and one or two vaccine doses, according to a […]

Reducing the initial screening age and including those with lower smoking exposures would help avert lung cancer-related deaths, according to a new study by the Cancer Intervention and Surveillance Modeling Network, led by a University of Michigan researcher. The modeling study, commissioned by the U.S. Preventive Services Task Force and […]

Just because you are exposed to a pathogen does not mean you will become sick. Increasingly, scientists have shown that genetics play a central role in determining whether the pathogens that cause a wide range of disease—including influenza, warts, and COVID-19—end up causing serious diseases. The lab of Jean-Laurent Casanova, which has spent 25 […]

One of the more interesting studies of cellular senescence in recent years was the demonstration that topical treatment with rapamycin, an inhibitor of mTOR signaling, over a period of months meaningfully reduced the burden of cellular senescence in the skin of aged individuals, leading to improvement in skin quality. It […]

People over 65 shouldn’t take three or more medicines that act on their brain and nervous system, experts strongly warn, because the drugs can interact and raise the risk of everything from falls to overdoses to memory issues. But a new study finds that 1 in 7 people with dementia who […]

New research from the University at Buffalo suggests that breast cancer patients who drink sugar-sweetened beverages regularly are at increased risk for death from any cause and breast cancer in particular. Compared to women who never or rarely drank non-diet soda, those who reported drinking non-diet soda five times or […]