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A fundamental process by which cellular components are degraded is Autophagy. Defects in Autophagy pathways are strongly associated with multiple human diseases, including neurodegenerative disorders and cancer. Despite their importance, to date, a comprehensive characterization of the extent and selectivity for Autophagic degrades has remained largely uncharacterized. Researchers at Karolinska […]

Liverpool cancer researchers have contributed to important new findings of the positive role of androgens in breast cancer treatment, with immediate implications for women with oestrogen receptor-positive (ER-positive) advanced disease. ER-positive breast cancer is the most common type of breast cancer diagnosed today, accounting for around 75 out of every […]

One more piece of the puzzle has fallen into place behind a new drug whose anti-cancer potential was developed at the University of Alberta and is set to begin human trials this year, thanks to newly published research. “The results provide more justification and rationale for starting the clinical trial in […]

NineSigma, representing Suntory Global Innovation Center Ltd. (“Client”), which serves as the Suntory Group's basic research department, seeks technologies for making a minimally invasive assessment of cellular senescence in the human clinical setting. The Client has in mind biomarker-based assessment methods but welcomes proposals for a wide range of other approaches. Anti-ageing is […]

Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease. Published in Nature Medicine, the international study conducted in collaboration with the Garvan Institute of Medical Research, looked at the […]

There is currently no cure for osteoarthritis, but a group of scientists believe they’ve discovered a method through which a simple knee injection could potentially stop the disease’s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration […]

The abnormal immune system response that causes multiple sclerosis (MS) by attacking and damaging the central nervous system can be triggered by the lack of a specific fatty acid in fat tissue, according to a new Yale study. The finding suggests that dietary change might help treat some people with […]

Fisetin is perhaps the most intriguing of the first generation senolytic compounds, those capable of selectively destroying senescent cells in old tissues and thus producing rejuvenation to a meaningful degree. Senolytics have been demonstrated in animal studies to reverse many age-related conditions to a greater degree than any other approaches. […]

Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own. There are two […]

A scientific study carried out by the Universidad Carlos III de Madrid (UC3M) and the Universidad Complutense de Madrid (UCM) has produced a mathematical description of the way in which a tumour invades the epithelial cells and automatically quantifies the progression of the tumour and the remaining cell islands after […]

Human genes have an impact on shaping our gut ecosystem according to new evidence from the international MIBioGen consortium study involving more than 18,000 people. The findings, led by the University Medical Center Groningen, Netherlands and involving researchers at the University of Bristol, are published today [18 January] in Nature […]

As the number of people who have fought off SARS-CoV-2 climbs ever higher, a critical question has grown in importance: How long will their immunity to the novel coronavirus last? A new Rockefeller study offers an encouraging answer, suggesting that those who recover from COVID-19 are protected against the virus […]