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Researchers at the University of New Hampshire have reported the first structural model for a key enzyme, and its activating protein, that can play a role in some genetically inherited eye diseases like retinitis pigmentosa and night blindness. “There has been substantial research on the biochemical pathway involving this enzyme, […]

Scientists are now able to label proteins in the brains of living mice who have a disease similar to Alzheimer’s disease, and have the labels remain in place. The tracer molecules have been developed at Linköping University. The new method allows the researchers to observe how harmful protein aggregates form […]

Sysmex Corporation and Eisai Co., Ltd. are pursuing a joint project to develop a method of diagnosing Alzheimer's disease (AD) using blood, presented two posters showing the most recent data from the project. The presentations took place at the 12th Clinical Trials on Alzheimer's Disease (CTAD) conference, from December 4 […]

Scientists have developed a new theory on the underlying cause of motor neurone disease, which could lead to more accurate diagnosis for patients and new treatments. A team at the University of Exeter has found evidence that the condition is caused by an imbalance in cholesterol and other fat levels […]

University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for harnessing CRISPR for clinical gene-therapy applications. By chemically tweaking the ends of the DNA to be inserted, the new technique is up to five times more […]

Spontaneous mutations in paternal sperm are linked to autism spectrum disorder; researchers have developed way to quantify those mutations and assess chances the mutations will cause disease. The causes of autism spectrum disorder or ASD are not fully understood; researchers believe both genetics and environment play a role. In some […]

New study shows exactly how the manner in which mitochondria divide has remained the same since evolution began. A group of scientists at Tokyo University of Science showed for the first time that in red algae, an enzyme that is usually involved in cell division also plays a role in […]

How mammals perceive light changes between night and day. Researchers at Aalto University and the University of Helsinki discovered that mice were better at finding a dim light in pitch-darkness in experiments done at night time compared to ones done during the day time. The scientists were surprised to find […]

Researchers at SciLifeLab report in the journal Science that they have created a detailed blood atlas of the proteins in human immune cells. The open-access database offers medical researchers an unprecedented resource in the search for treatments for diseases. The Blood Atlas resource is the latest database to be released […]

At least one in five cases of infertility remains unexplained. Malefactors contribute to about half of these cases and, much of the time, men lack a specific causal diagnosis for their infertility. Researchers estimate that genetics could explain up to 50 percent of these cases, but many of the genes […]

A discovery by Harvard Medical School investigators at Massachusetts Eye and Ear provides new clues that may help improve the prevention and treatment of Fuchs endothelial corneal dystrophy (FECD), a genetic eye disease that causes vision loss. Researchers have, for the first time, showing a mechanism that advances understanding of […]

Experimental, off-the-shelf immunotherapy that combines a targeted antibody and chemotherapy can lead to potentially durable responses in multiple myeloma patients whose disease has relapsed or is resistant to other standard therapies. A multi-center, international trial evaluated the drug, belantamab mafodotin, and found almost a third of patients whose disease had […]