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A Yale-led research team has developed an antibody that blocks tumors in animal models of colorectal cancer. If the finding is confirmed in clinical trials, the antibody-based treatment could become an effective weapon against colorectal cancer, and possibly other cancers, that resist current immunotherapies, the researchers said. The study was published […]

A research team led by a biochemist at the University of California, Riverside has solved the crystal structure for an enzyme that plays a key role in DNA methylation, the process by which methyl groups are added to the DNA molecule. DNA methylation alters gene expression. This fundamental cellular mechanism […]

“Our results are exciting and open the way for a medical treatment of this serious vascular disease,” says Professor Jesper Z. Haeggström at Karolinska Institutet’s Department of Medical Biochemistry and Biophysics. An aortic aneurysm occurs when the wall of the body’s largest artery, the aorta, weakens and swells. The disease progresses slowly and […]

But this insidious killer has an Achilles’ heel. Many leukemia cells are betrayed by a molecule on their exterior surfaces known as CD19. When activated, CD19 will kill the cancer cell to which it is attached. To cancer biochemists, CD19 is like a tiny radio signal broadcasting to the world, […]

The study, funded by the charity Pancreatic Cancer Research Fund, suggests that the new technique could potentially become a promising new treatment for patients with the aggressive disease, and could be combined with existing chemotherapy to improve chances of survival. Dr Stella Man, from BCI, said: “We’ve shown for the […]

Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine. The approach works for many different types of cancers, including those that […]

Investigators in the Division of Allergy, Pulmonary and Critical Care have launched a pilot study to see if patients with idiopathic pulmonary fibrosis (IPF) can tolerate the addition of a commonly used antiviral drug to standard IPF treatments. The research team believes the drug may ultimately help slow progression of […]

High exposure to radiofrequency radiation (RFR) in rodents resulted in tumors in tissues surrounding nerves in the hearts of male rats, but not female rats or any mice, according to draft studies from the National Toxicology Program (NTP). The exposure levels used in the studies were equal to and higher […]

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life. The generation of new nerve cells was once thought to […]

Wilmot Cancer Institute patients with advanced melanoma (stage III) now have more options for treatment, thanks to research co-authored by a University of Rochester Medical Center surgical oncologist and published in Lancet Oncology. The study involved comparing two treatment approaches for high-risk melanoma patients with a BRAF gene mutation in their cancer: standard […]

With their large buck teeth and wrinkled, hairless bodies, naked mole rats won’t be winning any awards for cutest rodent. But their long life span—they can live up to 30 years, the longest of any rodent—and remarkable resistance to age-related diseases, offer scientists key clues to the mysteries of aging […]

As part of a breast-cancer diagnosis, doctors analyze the tumor to determine which therapies might best attack the malignancy. But for patients whose cancer is triple-negative — that is, lacking receptors for estrogen, progesterone and Her2 — the options for treatment dwindle. Triple-negative cancers, or TNBC, also tend to be […]