October 27, 2017

Transplantation of young blood vessel cells boosts aging stem cells

Transplanting young blood vessel cells into older mice can make their aged stem cells take on the characteristics of young stem cells, leading to healthier blood systems and promoting better recovery from cancer treatment side effects, according to new research from Weill Cornell Medicine. Blood stem cells, also known as […]
October 26, 2017

Stemlike cells at tumor perimeter promote new blood vessels to feed tumor growth

Cancerous tumors need nutrients to grow, so they secrete factors promoting new blood-vessel formation to feed themselves. Researchers have long known that cells in low-oxygen environments at the center of the tumor send out these factors, but a new study by University of Illinois researchers found that stemlike cells at […]
October 26, 2017

Transplanted Hematopoietic Stem Cells Reverse Damage Caused by Neuromuscular Disorder

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich’s ataxia (FA) measurably halted cellular damage caused by the degenerative disease. The findings, published in the journal Science Translational Medicine, suggest a […]
October 25, 2017

New study shows how cells can be led down non-cancer path

As cells with a propensity for cancer break down food for energy, they reach a fork in the road: They can either continue energy production as healthy cells, or shift to the energy production profile of cancer cells. In a new study published Monday (Oct. 23, 2017) in the journal Nature […]
October 25, 2017

Infusion of vascular cells to treat liver cirrhosis shows promise

A new therapy that uses blood-vessel-lining cells to regenerate damaged tissue has the potential to treat liver cirrhosis, Weill Cornell Medicine scientists demonstrate in new research. The small-scale animal study, published in the journal Radiology, was a test of the basic feasibility of the cell delivery technique and not designed to […]
October 24, 2017

Researchers pinpoint causes for spike in breast cancer genetic testing

A sharp rise in the number of women seeking BRCA genetic testing to evaluate their risk of developing breast cancer was driven by multiple factors, including celebrity endorsement, according to researchers at the University of Georgia. “BRCA testing and counseling provide important information on the risk of developing breast and […]
October 24, 2017

Major study of genetics of breast cancer provides clues to mechanisms behind the disease

Seventy-two new genetic variants that contribute to the risk of developing breast cancer have been identified by a major international collaboration involving hundreds of researchers worldwide. Of these variants, reported today in the journals Nature and Nature Genetics, 65 are common variants that predispose to breast cancer and a further seven predispose specifically […]
October 24, 2017

Mutant Gene Found to Fuel Cancer-Promoting Effects of Inflammation

A human gene called p53, which is commonly known as the “guardian of the genome,” is widely known to combat the formation and progression of tumors. Yet, mutant forms of p53 have been linked to more cases of human cancer than any other gene. Investigating core mechanisms of how cancer cells […]
October 24, 2017

UA Lab Seeks 'Holy Grail of Gerontology'

A framed, black-and-white photo of Dr. Janko Nikolich-Zugich rests on a bookshelf in his office. He is seen in profile, head bent, a pen tucked into the pocket of his lab coat. Nikolich-Zugich is at work at his lab bench at New York's Memorial Sloan Kettering Cancer Center. Twenty-five years after […]
October 23, 2017

Nothing Wasted

Breast cancer cells recycle ammonia, a waste byproduct of cell metabolism, and use it as a source of nitrogen to fuel tumor growth, report scientists from Harvard Medical School in the journal Science. The findings, published online ahead of print on Oct. 12, show that the presence of ammonia accelerates proliferation […]
October 23, 2017

Dana-Farber and Brigham and Women's researchers laud FDA approval of CAR T-cell therapy for non-Hodgkin Lymphoma

Following a successful clinical trial involving Dana-Farber Cancer Institute and Brigham and Women's Hospital, the first chimeric antigen receptor (CAR) T-cell therapy for adult cancers was approved by the Food and Drug Administration (FDA) today. Dana-Farber/Brigham and Women's Cancer Center, the only facility in the northeast to be part of the clinical […]
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