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Dramatic calorie restriction, diets reduced by 40 percent of a normal calorie total, have long been known to extend health span, the duration of disease-free aging, in animal studies, and even to extend life span in most animal species examined. Further research has shown that animals fed restricted-calorie diets are […]

Researchers from the University of Pennsylvania have developed a gene therapy that successfully treats a form of macular degeneration in a canine model. The work sets the stage for translating the findings into a human therapy for an inherited disease that results in a progressive loss of central vision and which is […]

Cancer arises when cells acquire errors (mutations) at certain locations in the DNA. These mutations are responsible for the characteristics of the cancer cells, and knowledge about the mutations present in a patient’s cancer is important for the diagnosis and treatment. A subset of these mutations may even be “druggable” […]

Older women residing in the U.S territories are less likely to receive recommended or timely care for breast cancer compared with similar women residing in the continental United States, according to Yale researchers. Their findings were published in the March issue of Health Affairs. Using Medicare claims data from 2008 to […]

In many organs, damaged tissue can be repaired by generating new cells of the type that were lost. However, after an injury to the central nervous system, a special type of scar tissue is formed which inhibits this regeneration. Injuries to the brain and spinal cord therefore often lead to […]

Team engineers protein to enhance T cells for fight against cancer cells UCLA engineers and scientists have engineered a type of synthetic protein — a chimeric antigen receptor, or CAR, that responds to soluble protein targets. The advance shows great promise for helping the body’s immune system seek out and […]

A new discovery about the immune system may allow doctors to treat harmful inflammation that damages the brain in neurodegenerative diseases such as Alzheimer’s. It might also let doctors save patients from the potentially deadly inflammation of sepsis, a full-body infection that kills a quarter-million Americans every year. The finding […]

Improving the trafficking of cellular proteins in brain cells holds possibilities for new treatments and even prevention for Alzheimer's disease, results of a new study suggest. Researchers found that a compound that enhances the shuttling of proteins within cells reduced the production of forerunners of two proteins implicated in brain […]

People with stage III colon cancer who regularly eat nuts are at significantly lower risk of cancer recurrence and mortality than those who don’t, according to a new, large study led by researchers at Yale Cancer Center. The findings were published in the Journal of Clinical Oncology. The study followed 826 […]

Her two-year study, begun with funding from Women’s Health Research at Yale in 2005, found that long-term treatment with the sex hormones estrogen and progesterone did not improve memory as anticipated. “It was surprising, because we thought for sure we’d see a benefit of at least some of our treatments,” […]

Breast cancer is the most common form of cancer in women. In Sweden, almost two thousand patients die of the disease every year. The fatalities are almost exclusively a consequence of tumours in the breast spreading to other organs, such as the skeleton, the brain and the liver. Metastases in […]

Our bodies are not just passively growing older. Cells and tissues continuously use information from our environments—and from each other—to actively coordinate the aging process. A new study from the University of Michigan Life Sciences Institute now reveals how some of that cross-talk between tissues occurs in a common model […]