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With the growing interest in the accumulation of senescent cells as an important cause of aging, and more funding flowing into this part of the field, researchers are uncovering numerous direct links between cellular senescence and age-related conditions. Senescent cells cause harm to tissues via their inflammatory secretions, the senescence-associated […]

The emergency rooms in Barcelona were collapsing under the pressure. Hundreds of patients were arriving in desperate need as they struggled to breathe, while intensive care units struggled to cope with the sudden influx of respiratory problems. Epidemiologists scrambled to trace the source of the outbreak. This epidemic in the […]

What can the common fruit fly teach us about cancer? “Over the last few decades, the fruit fly – Drosophila melanogaster – has become a successful model for studying human cancers,” said Wu-Min Deng, Ph.D., professor of biochemistry and molecular biology and the Gerald and Flora Jo Mansfield Piltz Professor of […]

Peter Reddien's lab at the Whitehead Institute takes a step forward in understanding how neural circuits could be regenerated in adults. If anything happens to the eyes of the tiny, freshwater-dwelling planarian Schmidtea mediterranea, they can grow them back within just a few days. How they do this is a scientific conundrum […]

Stem cell activity declines with age throughout the body. In some cases this is because stem cells become less active in response to changes in the signaling environment. In other cases, the cells are damaged or the populations greatly reduced. The consequence of this decline is that fewer daughter somatic […]

Researchers at the University of East Anglia and the University of Manchester have made an important breakthrough that could lead to ‘kinder’ treatments for children with bone cancer, and save lives. Current treatment is grueling, with outdated chemotherapy cocktails and limb amputation. But despite all of this, the five-year survival […]

In a study published in PNAS, researchers from Karolinska Institutet, the Royal Institute of Technology (KTH), Nagoya University and Technische Universität Braunschweig show an undiscovered heterogeneity of adult zebrafish Purkinje cells, revealing the existence of anatomically and functionally distinct cell types. The cerebellum, sometimes referred to as the “tree of […]

Brain cancers have long been thought of as being resistant to treatments because of the presence of multiple types of cancer cells within each tumor. A new study uncovers a cancer cell hierarchy that originates from a single cancer cell type, which can be targeted to slow cancer growth. The […]

A new study from McGill University shows that increases in the concentrations of blood sodium can have an influence on the biological clock of mice, opening new research avenues for potentially treating the negative effects associated with long-distance travel or shift work. The findings, published in Nature by former McGill Ph.D. student […]

Research has found that those living with HIV have a higher risk for certain kinds of cancers—such as lung cancer. Now, with a new five-year, $3.7 million grant from the National Cancer Institute (NCI), researchers from Case Western Reserve University hope to find out why. Ge Jin, professor at the […]

A University of Michigan-led study is shedding new light on the way pancreatic cancer cells turn nearby connective tissue cells into co-conspirators in their deadly growth. The findings, which appear in Nature Metabolism, also suggest a new potential strategy against pancreatic cancer by identifying critical components of metabolic cross-talk between cells that might be […]

If you’ve ever been diagnosed with high cholesterol, also known as hyperlipidemia, your doctor has probably prescribed a statin. And while statins have been the go-to drug for managing cholesterol for nearly 25 years, there’s a new weapon in the fight. Recent studies suggest that adding a new class of medications — either […]