General

Scientists create synthetic exosomes with natural functionalities and present their therapeutic application. Scientists from the Max Planck Institute for Medical Research in Heidelberg and colleagues at the DWI Leibniz Institute for Interactive Materials in Aachen have engineered synthetic exosomes that regulate cellular signaling during wound closure. The synthetic structures are […]

Calorie restriction is the most studied means to slow aging, and from this numerous lines of work have emerged, each focused on one small subset of the sweeping changes in metabolism that occur in response to a lowered intake of nutrition. Lack of nutrients puts stress on cells and organisms, […]

Many lines of evidence point to kidney function as being particularly important to the health of organs throughout the body. To pick one example, one of the better known longevity-associated genes, klotho, appears to act in the kidney, and yet is well known for producing improvements in cognitive function. Here, […]

A new mechanism that stops the progression of Huntington’s disease in cells has been identified by scientists at the University of Cambridge and UCL, as part of their research groups at the UK Dementia Research Institute. Researchers say the breakthrough study, published in Cell Reports, could lead to much needed therapies […]

A growing school of thought sees persistent viral infection as an important contributing factor in age-related neurodegeneration. The widely varying burden of infection that is present in the population could help to explain the puzzling epidemiology of conditions such as Alzheimer's disease, in that only some of the people with […]

The CERN-developed COVID Airborne Risk Assessment tool (CARA) is helping researchers from the University of Geneva assess the effectiveness of different measures to limit SARS-CoV-2 aerosol transmission in schools. Having good safety measures at schools is very important as children start going back to the classroom. But which measures are […]

The age-related decline of the immune system is complex. There are many facets to the issues of increased systemic inflammation and reduced immune competence. Here, researchers show that a necessary population of memory B cells is reduced with age, and this impairs the ability of the immune system to respond […]

Since the COVID-19 pandemic reached the United States in early 2020, scientists have struggled to find laboratory models of SARS-CoV-2 infection, the respiratory virus that causes COVID-19. Animal models fell short; attempts to grow adult human lungs have historically failed because not all of the cell types survived. Undaunted, stem […]