General

CRISPR’s potential to prevent or treat disease is widely recognized. But the gene-editing technology can also be used as a research tool to probe and understand diseases. That’s the basic insight behind KSQ Therapeutics. The company uses CRISPR to alter genes across millions of cells. By observing the effect of […]

Although haemorrhoids are a common health problem, relatively little is known about the field, possibly because many people find them difficult to talk about. Researchers linked to Karolinska Institutet have been involved in a study that has analysed the genomes of almost a million people and found previously unknown causes […]

A novel drug almost entirely cleared moderate to severe psoriasis in over 60% of the patients who took part in two-phase three clinical trials of a new drug. The University of Manchester and Salford Royal NHS Foundation Trust led studies on Bimekizumab, both published in the prestigious New England Journal […]

The ability to cryopreserve and thaw organs via vitrification, without ice formation and significant tissue damage, allowing for indefinite storage time, would go a long way towards simplifying the logistics and reducing the costs of present organ donation and future tissue engineering of organs for transplantation. Cryopreservation via vitrification also […]

A new study by an international team of scientists, published on 22 April in the journal Science, has found that, in terms of genetic mutations, children whose parents were exposed to harmful contaminants during the Chernobyl accident, which took place in Ukraine in 1986, are no different from the general […]

It’s common knowledge that our surroundings affect our health — decades of research have linked things like air, water and soil quality to various measures of physical well-being. But much less is known about how the environment changes our brain. Now, a research team at the Keck School of Medicine […]

New research shows how drinking sugary beverages early in life may lead to impaired memory in adulthood. The study, published in Translational Psychiatry, also is the first to show how a specific change to the gut microbiome — the bacteria and other microorganisms growing in the stomach and intestines — can […]

If you feel your brain power diminishing as you advance into middle age and beyond, blame your neural stem cells. In a study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi demonstrates that neural stem cells—the stem cells of the nervous system—age rapidly. “There is chronological […]

A new ERC project aims to improve our understanding of enzyme stability and broaden the field of potential applications for biocatalysis. Professor John Woodley from DTU Chemical Engineering has received an Advanced Grant from ERC, the European Research Council. The grant of EUR 2.4 M will for the next five […]

There are millions of people who face the loss of their eyesight from degenerative eye diseases. The genetic disorder retinitis pigmentosa alone affects 1 in 4,000 people worldwide. Today, there is technology available to offer partial eyesight to people with that syndrome. The Argus II, the world’s first retinal prosthesis, […]

Real-world evidence is suggesting, for the first time, the most beneficial treatment courses that could help extend the lives of patients with metastatic non-small cell lung cancer, according to research from the Abramson Cancer Center at the University of Pennsylvania. In a new study published online in JAMA Oncology, researchers show that […]

Many approaches shown to slow aging in animal studies involve an increased efficiency of cell maintenance processes such as the ubiquitin-proteasome system and various types of autophagy. Here researchers discuss the improvement of autophagy in order to slow the age-related decline of mitochondrial function. Mitochondria are the power plants of […]

COVID-19 is not the first viral epidemic and it is not going to be the last one either. Humans have always dealt with such issues, but in the future they may become increasingly more common. One reliable way to make your body more resilient to such threats is regular physical […]

A new study of nearly 5 million live births recorded in California from 2001 to 2012 found that babies born to mothers diagnosed with cannabis use disorders at delivery were more likely to experience negative health outcomes, including preterm birth and low birth weight, compared to babies born to mothers […]

In two landmark studies, researchers have used cutting-edge genomic tools to investigate the potential health effects of exposure to ionizing radiation, a known carcinogen, from the 1986 accident at the Chernobyl nuclear power plant in northern Ukraine. One study found no evidence that radiation exposure to parents resulted in new […]

Cancer accounted for nearly 10 million deaths worldwide in 2020, and almost 2 million new cases are expected to be diagnosed this year in the United States alone. Fighting cancer’s many forms is a complex endeavour for doctors and researchers since there is no one-size-fits-all treatment option, but researchers at […]

The immune system is intimately involved in tissue function throughout the body, but particularly so in the brain. The immune system of the brain is distinct from that of the rest of the body, the two separated by the blood-brain barrier, and the immune cells of the brain participate in […]

Patients with atherosclerosis today usually receive preventive treatment only after a heart attack or stroke because diagnostic methods that can identify individuals and atherosclerotic plaques with high risk are lacking. In addition, the choice of treatment, both surgical and medical, is based on large patient studies and the possibilities for […]

The diagnosis of diseases like cancer almost always needs a biopsy – a procedure where a clinician removes a piece of suspect tissue from the body to examine it, typically under a microscope. Many areas of diagnostic medicine, especially cancer management, have seen huge advances in technology, with genetic sequencing, […]

University of Manchester scientists have cast new light on how our skin repairs itself, bringing the possibility of regeneration of the organ a step closer. The study team, funded by the Medical Research Council and Helmut Horten Foundation, showed the activation of specific parts of the DNA leading to better division of human skin cells. […]

New research has uncovered a possible link between vitamin D deficiency and impaired muscle function, which could help older adults better maintain muscle strength as they age. A study led by Dr Andrew Philp from the Garvan Institute of Medical Research, recently published in the Journal of Endocrinology, used experimental models to […]

The gut microbiome is a highly varied collection of microbial populations that acts in symbiosis with the body to process food and provide needed metabolites. With age, there is a detrimental shift in these populations. Those generating useful metabolites, such as butyrate, diminish in number. Those capable of infiltrating tissue, […]

A new study in laboratory rats has discovered a direct link between low oxygen in the womb and impaired memory function in the adult offspring. It also finds that anti-oxidant supplements during pregnancy may protect against this. Low oxygen in the womb – known as chronic fetal hypoxia – is […]

A new study by researchers at the University of Oxford, published today in Nature Medicine, identifies fetal head growth patterns that are associated with different developmental, behavioural, visual and growth outcomes at 2 years of age. The researchers identify, for the first time, a critical time period during pregnancy from […]

An international team, led by Stefan Raunser, Director at the Max Planck Institute of Molecular Physiology in Dortmund, in collaboration with Mathias Gautel at the King's College in London, has produced the first high-resolution 3D image of the sarcomere, the basic contractile unit of skeletal and heart muscle cells, by […]

Myelin is tremendously important for the correct and rapid transmission of electrical signals in the brain. This lipid-rich membrane, which wraps axons, is damaged in certain degenerative nerve disorders. Most of these are rare hereditary diseases with serious clinical courses. Generation of induced oligodendrocyte progenitor cells (iOPCs) from somatic fibroblasts […]

The new “LOOP Zurich – Medical Research Center” promotes patient-focused therapies – for example in oncology and neuro-rehabilitation. To achieve its goals, the centre brings together specialist knowledge in the fields of biomedicine, clinical research and bioinformatics from the University of Zurich, ETH Zurich as well as Zurich’s four university […]

The University of Toronto has partnered with Markham, Ont.-based Edesa Biotech on laboratory studies of a drug that physicians are already using at Canadian hospitals in a clinical trial for some of their sickest patients. Researchers at the Temerty Faculty of Medicine are about to receive their first shipment of the drug, […]

For cancer patients, the use of hematopoietic stem cell transplants can be a game-changer in terms of treatment and recovery. However, most people need to undergo a combination of chemotherapy and radiation before transplants become an option. A new article in Chemical & Engineering News, the weekly newsmagazine of the […]

Scientists have identified a potential drug target for treating obesity and eating disorders such as anorexia nervosa, a condition for which no therapeutics are currently available. In a new study scheduled to publish in Science Translational Medicine, a team of researchers from the University of Michigan and Vanderbilt University pinpoints […]