General

A new genome-wide CRISPR screening technique conducted by researchers at Vanderbilt University is offering new insights about how tumors in 80 to 90 percent of all cancers grow. This novel approach developed by Maria Fomicheva, a graduate student in the lab of Ian Macara, Louise B. McGavock Professor and professor of cell […]

Approximately two years after establishing a human cerebral organoid system to study Creutzfeldt-Jakob disease (CJD), National Institutes of Health researchers have further developed the model to screen drugs for potential CJD treatment. The scientists, from NIH’s National Institute of Allergy and Infectious Diseases (NIAID), describe their work in Scientific Reports. Human […]

Researchers have identified changes in the metabolism of liver and skeletal muscle cells in live mice that are likely connected to obesity-associated metabolic disorders. This study was led by Professor Shinya Kuroda, head of the Systems Biology Lab at the University of Tokyo and an expert in trans-omics research, which […]

Stopping smoking leads to healthier, wealthier and happier lives say researchers from University of Bath’s Addiction & Mental Health Group. New evidence published in the Cochrane Library suggests that smokers who quit can feel the positive benefits within weeks. The research, led by Dr Gemma Taylor from the University of Bath’s Addiction & […]

An interesting fact about the adaptive immune system: the number of T cells in the body remains much the same across the entire lifespan, even after the supply of new T cells all but ceases in middle age. T cells are created as thymocytes by hematopoietic cells in the bone […]

Delaying second doses of COVID-19 vaccines should reduce case numbers in the near term; however, the longer-term case burden and the potential for evolution of viral ‘escape’ from immunity will depend on the robustness of immune responses generated by natural infections and one or two vaccine doses, according to a […]

Reducing the initial screening age and including those with lower smoking exposures would help avert lung cancer-related deaths, according to a new study by the Cancer Intervention and Surveillance Modeling Network, led by a University of Michigan researcher. The modeling study, commissioned by the U.S. Preventive Services Task Force and […]

Just because you are exposed to a pathogen does not mean you will become sick. Increasingly, scientists have shown that genetics play a central role in determining whether the pathogens that cause a wide range of disease—including influenza, warts, and COVID-19—end up causing serious diseases. The lab of Jean-Laurent Casanova, which has spent 25 […]

One of the more interesting studies of cellular senescence in recent years was the demonstration that topical treatment with rapamycin, an inhibitor of mTOR signaling, over a period of months meaningfully reduced the burden of cellular senescence in the skin of aged individuals, leading to improvement in skin quality. It […]

People over 65 shouldn’t take three or more medicines that act on their brain and nervous system, experts strongly warn, because the drugs can interact and raise the risk of everything from falls to overdoses to memory issues. But a new study finds that 1 in 7 people with dementia who […]

New research from the University at Buffalo suggests that breast cancer patients who drink sugar-sweetened beverages regularly are at increased risk for death from any cause and breast cancer in particular. Compared to women who never or rarely drank non-diet soda, those who reported drinking non-diet soda five times or […]

Some of Princeton’s leading cancer researchers were startled to discover that what they thought was a straightforward investigation into how cancer spreads through the body — metastasis — turned up evidence of liquid-liquid phase separations: the new field of biology research that investigates how liquid blobs of living materials merge […]

Scientists at the University of Virginia School of Medicine have developed a tool to monitor communications within the brain in a way never before possible, and it has already offered an explanation for why Alzheimer’s drugs have limited effectiveness and why patients get much worse after going off of them. The […]

PNNL bioinformatics experts tease out link to DNA repair signaling Night shift work disrupts the natural 24-hour rhythms in the activity of certain cancer-related genes, making workers more vulnerable to damage to their DNA while at the same time causing the body’s DNA repair mechanisms to be mistimed to deal with […]

Being active and fit slows the impact of aging on the brain. A diverse set of mechanisms are involved, and, as is often the case in these matters, it is far from clear as to which of these mechanisms are the most important. Fitness helps to maintain the vascular system […]

For cancer cells to metastasize, they must first break free of a tumor’s own defenses. Most tumors are sheathed in a protective “basement” membrane — a thin, pliable film that holds cancer cells in place as they grow and divide. Before spreading to other parts of the body, the cells […]

Scientists at ETH Zurich are working to develop information-​processing switching systems in biological cells. Now, for the first time, they have developed an OR switch in human cells that reacts to different signals. Biological cells might one day be equipped with artificial genetic programs that work in much the same […]

Scientists at Washington University School of Medicine in St. Louis have implicated a type of immune cell in the development of chronic lung disease that sometimes is triggered following a respiratory viral infection. The evidence suggests that activation of this immune cell — a type of guardian cell called a […]

Managing single risk factors like blood pressure rather than looking at overall risk may be wasting scarce resources in countries where cardiovascular disease (CVD) is on the rise, according to a new study. Researchers looked at country-specific levels of cardiovascular risk, associations with socio-demographic factors and whether WHO guidelines on the […]

The ambitious project aims to preserve humankind – and animal-kind, plant-kind and fungi-kind – in the event of a global crisis. University of Arizona researcher Jekan Thanga is taking scientific inspiration from an unlikely source: the biblical tale of Noah's Ark. Rather than two of every animal, however, his solar-powered […]

Melanoma is the most aggressive and deadliest form of skin cancer. Effective treatments are elusive because one type of this cancer develops resistance to available inhibitors, and in another type, no effective drug treatment has yet been found. But a promising pathway to effective drug treatment of both types of […]

Powerful new genetic engineering methods have given scientists the potential to revolutionize several sectors of global urgency. So-called gene drives, which leverage CRISPR technology to influence genetic inheritance, carry the promise of rapidly spreading specific genetic traits throughout populations of a given species. Gene-drive technologies applied in insects, for example, […]

COVID-19 has been with us for more than a year already. But do you remember how little we knew about it just one year ago? We didn’t know what this viral disease can do to children. It turned out, they are more immune to COVID-19 than adults are. But why? […]

Incorporating social and behavioral factors alongside biological mechanisms is critical for improving aging research, according to a trio of studies by leading social scientists. A trio of recent studies highlight the need to incorporate behavioral and social science alongside the study of biological mechanisms in order to slow aging. The […]

Human population in the world is growing. And we will need to feed all these people. How can we do that without limited resources and farming capabilities, not putting even more damage on the wildlife. Scientists at the University of Melbourne have put their ears on the clock the plants […]

Using cellular genomics, Garvan-led researchers have uncovered new links between DNA variants and cell gene activity. Researchers led by the Garvan Institute of Medical Research have made a crucial step forward in the understanding of how our own DNA information influences our personal disease risk, thanks to cutting-edge cellular genomics […]

A newly announced grant from the MS Society is helping researchers at the University of Alberta to better understand the underlying cause of chronic pain that afflicts an estimated half of people with multiple sclerosis, and how to eradicate it. Bradley Kerr and his team are looking in particular at the peripheral nervous […]

It looks like science fiction: A machine dips into a shallow vat of translucent yellow goo and pulls out what becomes a life-sized hand. But the seven-second video, which is sped-up from 19 minutes, is real. The hand, which would take six hours to create using conventional 3D printing methods, […]

Taking the first deep dive into how the immune system is behaving in patients with multisystem inflammatory syndrome in children (MIS-C), researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have found that children with this condition have highly activated immune […]

Study reveals details of how coronavirus infects heart; models of tissue damage may help develop potential therapies. Since early in the pandemic, COVID-19 has been associated with heart problems, including reduced ability to pump blood and abnormal heart rhythms. But it’s been an open question whether these problems are caused […]