General

A Virginia Tech research team has discovered insights into the stabilizing forces of amyloid fibrils that are associated with Alzheimer’s disease and type 2 diabetes. These findings were recently published in the Journal of Molecular Biology. Amyloids are aggregates of proteins that form a shape that allows many copies of that protein […]

A major study has found that medicines used to treat diabetes in adults are not effective on youth. Researchers say the finding is disturbing because type 2 diabetes among youth is a growing problem. In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug […]

Immune cells commonly blamed in Alzheimer’s and other neurodegenerative diseases are actually precision cleaning machines protecting the central nervous system, new research from the University of Virginia School of Medicine shows. The discovery adds nuance and complexity to our understanding of immune cells known as microglia. By appreciating the role of these cells in full, […]

A first-ever tissue implant to safely treat a common jaw defect, known as temporomandibular joint dysfunction, has been successfully tested by UCI-led researchers in animals. “We were able to show that we could achieve exceptional healing of the TMJ area after eight weeks of treatment,” said UCI Distinguished Professor of […]

A new microscope system can image living tissue in real time and in molecular detail, without any chemicals or dyes, report researchers at the University of Illinois. The system uses precisely tailored pulses of light to simultaneously image with multiple wavelengths. This enables the researchers to study concurrent processes within […]

Poor protein in a mother’s diet in early pregnancy, around the time of conception, can have a lasting effect on brain development, according to research recently published by University of Southampton academics. The project, led by Dr Sandrine Willaime-Morawek, in collaboration with Professor Tom Fleming, is the first to clearly […]

From the spatter analysis made famous in the TV show Dexter to the frequent DNA profiling of CSI and the real cases covered in the FBI Files, blood tests are ubiquitous in forensic science. Now, researchers report in ACS Central Sciencethat a new blood test, which could be performed at a crime scene, could help determine […]

Discovery could be a step toward developing treatments for cancer and autoimmune diseases. UCLA researchers have developed synthetic T lymphocytes, or T cells, that are near-perfect facsimiles of human T cells. The ability to create the artificial cells could be a key step toward more effective drugs to treat cancer […]

Analysis of large data sets from post-mortem brain samples of people with and without Alzheimer’s disease has revealed new evidence that viral species, particularly herpesviruses, may have a role in Alzheimer’s disease biology. Researchers funded by the National Institute on Aging (NIA), part of the National Institutes of Health, made […]

Scientists seeking to unlock the secrets of cellular aging have identified a gene that triggers senescence, a phenomenon in which cells stop dividing. Senescence is a natural occurrence in the life of a cell, and researchers have sought to learn about it for a couple of reasons. First, it’s connected […]

The disappearance of an entire brain region should be cause for concern. Yet, for decades scientists have calmly maintained that one brain area, the subplate, simply vanishes during the course of human development. Recently, however, research has revealed genetic similarities between cells in the subplate and neurons implicated in autism—leading a […]

A so-called “jumping gene” that researchers long considered either genetic junk or a pernicious parasite is actually a critical regulator of the first stages of embryonic development, according to a new study in mice led by UC San Francisco scientists and published in Cell. Only about 1 percent of the human […]

Each year, 300,000 infants worldwide are born with a genetic disease that warps the shape of their red blood cells, which break apart and fail to deliver life-giving oxygen, or pile up in tiny blood vessels and result in episodes of severe pain, swelling of hands and feet, organ damage, […]

A new study by the Yale School of Public Health and partner institutions is the first to examine the potential cancer prevention benefits of prolonged periods of HIV viral suppression, resulting from antiretroviral therapy, for persons living with HIV. The researchers compared cancer rates for 42,441 HIV-positive veterans with those […]

Maurizio Pellecchia, who holds the Daniel Hays Chair in Cancer Research at the University of California, Riverside, has received two grants to continue his research aimed at finding therapeutics for cancer, amyotrophic lateral sclerosis (ALS), and other neurodegenerative diseases. The first grant from the U.S.-Egypt Science and Technology Joint Fund […]

As the result of a six-year long research process, Fredrick R. Schumacher, a cancer epidemiology researcher at Case Western Reserve University School of Medicine, and an international team of more than 100 colleagues have identified 63 new genetic variations that could indicate higher risk of prostate cancer in men of […]

Our ability to learn, remember, problem solve, and speak are all cognitive functions related to different parts of our brain. If researchers can identify how those brain parts communicate and exchange information with each other, clinicians and surgeons can better understand how diseases like Alzheimer’s and brain cancer affect those […]

The cell has its own paramedic team and emergency room to aid and repair damaged DNA, a new USC study reveals. The findings are timely, as scientists are delving into the potential of genome editing with the DNA-cutting enzyme CRISPR-Cas9 to treat diseases or to advance scientific knowledge about humans, […]

Working with hundreds of time-lapse videos of mouse tissue, a team of biologists joined up with civil engineers to create what is believed to be the first 3D computer model to show precisely how the tiny tubes that funnel milk through the breasts of mammals form. A report on the model was […]

Exercise is a proven factor in decreasing the risk of a heart attack, but convincing at-risk patients with heart disease to commit to regular exercise programs is a challenge. Researchers at Penn Medicine have published the results of a clinical trial in the Journal of the American Heart Association, which show that offering payment up front, and […]

In many ways, the process to heal a wound parallels the steps involved in repairing, for example, a pothole. Both require specific supplies: cells and platelets, or asphalt and sand. And both processes necessitate a way transport those supplies, like a safe and accessible roadway. For the body, that means a network of […]

Breakthrough in description of metals in brain which may drive the progression of Alzheimer's disease, made by international research collaboration, including University of Warwick. Alzheimer's disease could be better treated, thanks to a breakthrough discovery of the properties of the metals in the brain involved in the progression of the […]

Patients with pancreatic cancer usually experience significant weight loss, which can begin very early in the disease. A new study from MIT and Dana-Farber Cancer Institute offers insight into how this happens, and suggests that the weight loss may not necessarily affect patients’ survival. In a study of mice, the […]

Symptoms of schizophrenia and bipolar disorder, including psychosis, depression and manic behavior, have both shared and distinguishing genetic factors, an international consortium led by researchers from Vanderbilt University and Virginia Commonwealth University is reporting. The consortium’s findings, which were published online in the journal Cell, are raising hopes that genetics could […]

Most protein info ever captured from a single cell thanks to new 'nanoPOTS' technology Scientists have obtained a slew of key information about proteins, the molecular workhorses of all cells, from single human cells for the first time.The stockpile of information about proteins — the most such data ever collected […]

Correlative light-electron microscopy is being used to increase our knowledge of how platelets are made in the body and the results are challenging previously held understandings. Platelets are uniquely mammalian cells, and are the small cells of the blood that are critical for us to stop bleeding when we cut […]

The Big Question At some point in a stem cell's life, it must make an irreversible transition to develop into a particular cell type. When this happens, its nucleus begins to bustle with activity: Proteins called transcription factors latch onto the cell's DNA at specific locations (called binding sites) to […]

Known as DNA charge transport, this biochemical process was first discovered in the early 1990s by Caltech's Jacqueline Barton, the John G. Kirkwood and Arthur A. Noyes Professor of Chemistry, through chemistry experiments using synthetic DNA. Her research group then found evidence that this charge transport chemistry might be utilized by […]

Early detection has been shown to increase breast cancer survival rates, but many women avoid having their mammograms taken as often as they should because of the discomfort involved. A 2013 study found that as many as half of women who were avoiding their mammograms cited pain as the reason […]

The development of an aggressive, early-onset form of colon cancer may come down to a single missing iron atom in a key DNA repair protein, according to findings from a research collaboration between the University of Michigan Life Sciences Institute, the California Institute of Technology and the University of Southern […]