March 24, 2021

Research shows how tissue's microscopic geometry affects spread of cancer

Oregon State University research has revealed a crucial mechanism behind one of humankind's most deadly physiological processes: the movement of malignant cells from one part of the body to another. Published in Proceedings of the National Academy of Sciences, the U.S. National Science Foundation-funded study led by OSU biophysicist Bo Sun shows the role […]
March 23, 2021

CAR T-cell therapy generates lasting remissions in patients with multiple myeloma

In a major advance in the treatment of multiple myeloma, a CAR T-cell therapy has generated deep, sustained remissions in patients who had relapsed from several previous therapies, an international clinical trial has found. In a study posted online today by the New England Journal of Medicine, trial leaders report […]
March 23, 2021

Taking new steps with artificial platelets

A team of researchers, led by biomedical engineering professor Anirban Sen Gupta, is working toward innovating and advancing platelet-inspired nanotechnology systems to treat severe bleeding in surgery and trauma. The National Institutes of Health (NIH) has awarded a $2.1 million, four-year research grant to Sen Gupta and collaborators at the University of […]
March 23, 2021

Viagra may prolong life for men with coronary artery disease

Men with stable coronary artery disease who are on Viagra due to impotence seem to live longer and have a lower risk of experiencing a new heart attack, a study from Karolinska Institutet in Sweden published in the Journal of the American College of Cardiology reports. Impotence can be an […]
March 23, 2021

Fourth generation of e-cigarettes is not harmless

A University of California, Riverside, study analyzing fourth-generation electronic cigarette, or EC, pod atomizer design features have found the pod atomizers are similar to those of previous generations and contain elements that may adversely affect health and accumulate in the environment. EC atomizers are chambers that hold nicotine-containing fluid and […]
March 23, 2021

Penn, CHOP and Yale Researchers’ Molecular Simulations Uncover How Kinase Mutations Lead to Cancer Progression

Kinases are a class of enzymes that are responsible for transferring the main chemical energy source used by the body’s cells. As such, they play important roles in diverse cellular processes, including signalling, differentiation, proliferation and metabolism. But since they are so ubiquitous, mutated versions of kinases are frequently found […]
March 22, 2021

The Binarized Transcriptomic Aging Clock

Patterns of epigenetic regulation of gene expression (and thus RNA and protein levels) change constantly in response to cell state and environment. Some of those changes are characteristic responses to the damage and dysfunction of aging. Since the demonstration of the first epigenetic clocks, those that predict age based on […]
March 22, 2021

Vaccination by inhalation

Many viruses infect their hosts through mucosal surfaces such as the lining of the respiratory tract. MIT researchers have now developed a vaccination strategy that can create an army of T cells that are ready and waiting at those surfaces, offering a quicker response to viral invaders. The researchers showed […]
March 22, 2021

New technology ‘retrains’ cells to repair damaged brain tissue in mice after stroke

Most stroke victims don’t receive treatment fast enough to prevent brain damage. Scientists at Ohio State University have developed technology to “retrain” cells to help repair damaged brain tissue – an advancement that may someday help patients regain speech, cognition and motor function, even when administered days after an ischemic […]
March 22, 2021

Health declining in Gen X and Gen Y, national study shows

Recent generations show a worrying decline in health compared to their parents and grandparents when they were the same age, a new national study reveals. Researchers found that, compared to previous generations, members of Generation X and Generation Y showed poorer physical health, higher levels of unhealthy behaviours such as […]
March 22, 2021

Bioengineers learn the secrets to precisely turning on and off genes

In a recent study led by the University of Bristol, scientists have shown how to simultaneously harness multiple forms of regulation in living cells to strictly control gene expression and open new avenues for improved biotechnologies. Engineered microbes are increasingly being used to enable the sustainable and clean production of […]
March 22, 2021

Cancer Immunotherapy May Also Treat Certain Autoimmune Diseases

A team of researchers has found disrupting the interaction between cancer cells and certain immune cells is more effective at killing cancer cells than current immunotherapy treatments. The findings, which include studies in cell lines and animal models, appeared in JCI Insight and focus on a protein called CD6 as a target for […]