2021

Researchers at the National Institutes of Health have discovered a new genetic disorder characterized by developmental delays and malformations of the brain, heart and facial features. Named linkage-specific-deubiquitylation-deficiency-induced embryonic defects syndrome (LINKED), it is caused by a mutated version of the OTUD5 gene, which interferes with key molecular steps in embryo development. […]

Nowadays, the fashion trends and cosmetics industry promote fitness and “perfect” body types. Strict following of these “recommendations” may have harmful consequences. Social media do not help, promoting standards – to stay healthy and beautiful, measured in clothing sizes. Usually, there is no room for being “just average”. A larger […]

The United States is facing an epidemic of liver disease linked to obesity. Cases of nonalcoholic fatty liver have more than doubled in the past two decades, now affecting around one-quarter of the country’s population. The condition leads to inflammation and scarring in the liver, similar to that caused by […]

University of Alberta researchers have discovered a potential biomarker—the response of a particular reflex in the body dubbed the Hoffmann reflex—that would help surgeons deliver deep brain stimulation (DBS) more precisely and effectively to patients with advanced Parkinson’s disease. The work, led by U of A neurosurgeon Tejas Sankar, was recently published in […]

Several genetic mutations previously linked to breast cancer and included on commercial genetic tests, including direct-to-consumer tests, were found not to increase a woman’s risk of disease, according to a population study of more than 64,000 women published online in the New England Journal of Medicine from several institutions, including Penn Medicine. […]

The colons of African Americans and people of European descent age differently, new research reveals, helping explain racial disparities in colorectal cancer – cancer that killed beloved “Black Panther” star Chadwick Boseman at only 43. Scientists led by UVA Health’s Dr Li Li and Graham Casey, along with Matt Devall […]

Although prostate cancer is one the most common types of malignancy in men, diagnosis is typically made on the basis of the Prostate-specific antigen (PSA), with an accuracy as low as 30%. Given how unreliable PSA-based testing can often be, many patients require invasive biopsy which often leaves them with […]

A fundamental process by which cellular components are degraded is Autophagy. Defects in Autophagy pathways are strongly associated with multiple human diseases, including neurodegenerative disorders and cancer. Despite their importance, to date, a comprehensive characterization of the extent and selectivity for Autophagic degrades has remained largely uncharacterized. Researchers at Karolinska […]

Liverpool cancer researchers have contributed to important new findings of the positive role of androgens in breast cancer treatment, with immediate implications for women with oestrogen receptor-positive (ER-positive) advanced disease. ER-positive breast cancer is the most common type of breast cancer diagnosed today, accounting for around 75 out of every […]

One more piece of the puzzle has fallen into place behind a new drug whose anti-cancer potential was developed at the University of Alberta and is set to begin human trials this year, thanks to newly published research. “The results provide more justification and rationale for starting the clinical trial in […]

NineSigma, representing Suntory Global Innovation Center Ltd. (“Client”), which serves as the Suntory Group's basic research department, seeks technologies for making a minimally invasive assessment of cellular senescence in the human clinical setting. The Client has in mind biomarker-based assessment methods but welcomes proposals for a wide range of other approaches. Anti-ageing is […]

Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease. Published in Nature Medicine, the international study conducted in collaboration with the Garvan Institute of Medical Research, looked at the […]