2021

Cancer cells have evolved mechanisms to escape the body's immune defense. Agents that prevent immune escape are attractive targets for the development of new cancer therapies. A group of scientists led by Herbert Waldmann and Slava Ziegler at the Max Planck Institute of Molecular Physiology in Dortmund has now developed […]

Piperlongumine, an extract of long peppers, was shown to be senolytic a few years ago. The compound is capable of selectively destroying senescent cells by sensitizing them to oxidative damage, provoking apoptosis. The accumulation of senescent cells is one of the causes of aging, and means of clearance are thus […]

Screening tools for autism spectrum disorder (ASD) often fail to identify ASD among children from low-income families and racial/ethnic minority groups, particularly when English is not the family’s primary language. A new visually-based tool may reduce these disparities at a pivotal point in children’s development. In Pediatrics, Zuleyha Cidav, David Mandell, and colleagues found […]

Head injury in the United States is common, with over 23 million adults age 40 or older reporting a history of head injury with loss of consciousness. Many head injuries can be caused by a host of different situations – from car and motorcycle accidents to sports injuries. What’s more, it […]

Anyone who has watched an infant’s eyes follow a dangling trinket dancing in front of them knows that babies are capable of paying attention with laser focus. But with large areas of their young brains still underdeveloped, how do they manage to do so? Using an approach pioneered at Yale […]

Nearly every older adult has prescribed a prescription drug that increased their risk of falling in 2017, according to new University at Buffalo research. The study found that the percentage of adults 65 and older who were prescribed a fall- risk-increasing drug climbed to 94% in 2017, a significant leap […]

A worldwide clinical trial aimed at finding treatments for Alzheimer’s disease has expanded to include investigational drugs targeting a harmful form of the brain protein tau. The trial, known as the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) and led by Washington University School of Medicine in St. Louis, launched […]

New software advances ability to turn stem cells into other cell types. Harvard Medical School researchers and colleagues have developed new software to help scientists generate different types of cells for use in research and medicine. The software aids ongoing efforts to turn induced pluripotent stem cells, or IPSCs—adult cells that […]

This interesting study shows that when given the choice to consume sugar or protein, flies consume a lot of sugar and exhibit reduced life span as a result. Feeding the same proportional mix of sugar and protein to flies without giving them the choice of what to consume does not […]

To date, not much is known about two similar, but different, pediatric rheumatic conditions: juvenile myositis, an autoimmune disease where the immune system attacks its own tissue and causes inflammation in the muscles, and systemic lupus erythematosus, the most common and serious form of lupus where the immune systems attacks its own […]

Mapping the cerebral vascular network in human patients, at unprecedented scales: this tour de force has been achieved by the French laboratory Physics for Medicine Paris (ESPCI Paris-PSL, Inserm, CNRS). In a study published on the front page of Nature Biomedical Engineering, the research team details its method: ultrasound localization […]

Scientists report on the structural and molecular factors governing the stability of a protein complex involved in DNA repair pathways in cells. The cells in our body are constantly fighting off the threat of cancer by repairing damaged DNA. In a new study, scientists from Tokyo University of Science investigate […]