December 19, 2020

IL-6 Contributes to Age-Related Loss of Mitochondrial Function in Cerebral Vasculature

Chronic inflammation grows with age throughout the body, characterized by increased levels of numerous inflammatory signal molecules, among which is IL-6. One contributing factor to the chronic inflammation of aging is the accumulation of lingering senescent cells, which rouse the immune system via secreted molecules that include, prominently, IL-6. Researchers […]
December 19, 2020

Cataract surgery in infancy increases glaucoma risk

Children who undergo cataract surgery as infants have a 22% risk of glaucoma 10 years later, whether or not they receive an intraocular lens implant. The findings come from the National Eye Institute (NEI)-funded Infant Aphakic Treatment Study, which today published 10-year follow-up results in JAMA Ophthalmology. NEI is part […]
December 19, 2020

Protein involved in removing Alzheimer’s buildup linked to circadian rhythm

Fractured sleep, daytime sleepiness and other signs of disturbance in one’s circadian rhythm are common complaints of people with Alzheimer’s disease, and the problems only get worse as the disease progresses. But the reason for the link between Alzheimer’s and circadian dysfunction is not well understood. Researchers at Washington University […]
December 19, 2020

Seeking to avoid ‘full lockdown,’ cells monitor ribosome collisions

Ribosomes are the machines in the cell that use instructions from mRNA to synthesize functional proteins. There are hundreds of thousands of ribosomes in each cell, and they mostly process their instructions faithfully. But sometimes ribosomes get stuck or stall on roadblocks along with defective mRNA molecules. New research from […]
December 18, 2020

CIHR and JDRF funding drives efforts to find new stem cell-based therapies for Type 1 diabetes

University of Alberta researchers are among two Canadian research teams chosen for significant new funding from the Government of Canada and JDRF Canada to develop new stem cell-based therapies for treating Type 1 diabetes. The projects will each receive $1.5 million from the Canadian Institutes of Health Research Institute of Nutrition, Metabolism […]
December 18, 2020

ACE2 protein that prevents heart, lung and kidney disease in women also protects against severe COVID-19: study

Female COVID-19 patients face less severe disease complications and a lower risk of dying than male patients thanks to hormones and chromosomes that contribute to a stronger immune response, according to new research from a University of Alberta-led team. “The highlight of our study is how the sex differences in COVID-19 are […]
December 18, 2020

Research strongly suggests COVID-19 virus enters the brain

More and more evidence is coming out that people with COVID-19 are suffering from cognitive effects, such as brain fog and fatigue. And researchers are discovering why. The SARS-CoV-2 virus, like many viruses before it, is bad news for the brain. In a study published in Nature Neuroscience, researchers found […]
December 18, 2020

Jawless Lamprey Takes a Bite out of Oncogene Evolution

Mice, fruit flies and dogs are common creatures of laboratories across the country, valuable to researchers for their genetic proximity to humans. But what about lampreys? A new Yale School of Public Health study has enlisted this unlikely and slimy ally in the fight against cancer. By carefully tracing the […]
December 18, 2020

'Hearing' Autism

Autism spectrum disorder, estimated to affect one in 54 children in the United States, encompasses a range of complex neurodevelopmental conditions that typically emerge in the first few years of life. Yet for a variety of reasons, these conditions could be challenging to diagnose early when interventions are most likely to avert or […]
December 18, 2020

North south divide, not age, linked to hearing loss

An increase of over 10% in the prevalence of hearing loss in the English over 50s may not be age-related, a new study by University of Manchester researchers has shown. Instead the study, published in BMC Geriatrics, found hearing loss could be linked to social and lifestyle differences in the north and […]
December 17, 2020

Senescent Cells Fail to Maintain Proteostasis

Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking place than was previously the case. In many cases it isn't all that clear […]
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