General

Children with high-risk cancers have received effective treatments leading to complete or partial regression of their cancer thanks to a pioneering research program that tailors therapy based on the complete DNA sequence of a patient’s individual tumour. A report of 247 participants of the Zero Childhood Cancer Program published in […]

Researchers from Karolinska Institutet demonstrate that genetic risk score for ADHD can influence how autistic individuals respond to standard interventions and the specific program on social skills training KONTAKT®. This study is now published in npj Genomic Medicine. “Our ultimate goal is to be able to use genetic information to […]

Differences in the microstructure of the nucleus accumbens (NAcc), a region in the brain that plays an important role in processing food and other reward stimuli, predict increases in indicators of obesity in children, according to a study funded by the National Institute on Drug Abuse (NIDA) and nine other […]

reatment of metastatic gastrointestinal solid tumor cancer. The Phase II clinical trial, which will use cutting-edge CRISPR genetic engineering, has opened exclusively at the M Health Fairview University of Minnesota Medical Center, and has already begun enrolling patients. This trial comes on the heels of groundbreaking research from a consortia […]

Pioneering analysis of 200 million-year-old teeth belonging to the earliest mammals suggests they functioned like their cold-blooded counterparts – reptiles, leading less active but much longer lives. The research, led by the University of Bristol, UK and University of Helsinki, Finland, published in Nature Communications, is the first time palaeontologists have […]

Women with inflammatory breast cancer — a rare, highly aggressive form of the disease — are living about twice as long after diagnosis than their counterparts in the mid-to-late 1970s, according to a new University of Michigan Rogel Cancer Center study. The researchers found that from 1973-1977, patients diagnosed with inflammatory breast […]

Lower levels of the vitamin negatively impacted balance and coordination. When it comes to vitamin D, most adults exhibit either frank deficiency, which results in clear clinical symptoms, or insufficiency, which often goes undetected. But how that insufficiency impacts physical health and the vulnerability of older adults to frailty as […]

In response to certain types of injury and inflammation, many organs produce tough scar tissue, a process called fibrosis, which can ultimately lead to organ failure or even death. Fibrosis is such a central component of so many different diseases – from cardiovascular disease to kidney failure – that scientists […]

Oregon State University scientists have developed a method that could potentially predict the cancer-causing potential of chemicals released into the air during wildfires and fossil fuel combustion. The research, which was recently published in the journal Toxicology in Vitro, was conducted as a part of the OSU Superfund Research Program.  The findings […]

A greater density of cells in a key reward centre of the brain is associated with obesity in children and predicts future weight gain, a new Yale-led study finds. The findings, published in the Proceedings of the National Academy of Sciences, suggest that a greater concentration of specialized cells in […]

The white blood cell TH17 helps the immune system fight infection by promoting inflammation. But it can be too much of a good thing: Excessive inflammation from TH17 overload has been tied to autoimmune disorders, such as inflammatory bowel disease (IBD) and arthritis. Researchers led by Hening Lin, professor of chemistry […]

A University of Oregon-initiated project using tiny roundworms has identified defects tied to infertility that result when too much DNA is exchanged in the formation of sperm and eggs. The fundamental research, detailed in a paper placed online in PLOS Genetics, probed what happens when too many DNA exchanges, called […]