November 20, 2018

Case Western Reserve’s Ahmad Khalil receives NIH funding to develop new paradigm in fight against colorectal cancer

Certain genes that code for proteins have long been known to contribute to cancer progression. But in a frame shift, researchers from Case Western Reserve University School of Medicine recently found that non-coding genes also contribute to the development and spreading of the disease, one of the first known examples […]
November 20, 2018

New immunotherapy improves MS symptoms

A world-first clinical trial of a new cellular immunotherapy for multiple sclerosis (MS) has improved symptoms and quality of life for the majority of patients. The treatment targets the Epstein-Barr virus (EBV), and is based on a theory formulated by University of Queensland and Royal Brisbane and Women’s Hospital (RBWH) […]
November 19, 2018

New CRISPR-Based Tool could Substantially Enhance Immune Response to Cancer

These days, scientists are fairly adept at reprogramming immune cell pathways to enhance the immune system’s own response to cancerous lesions, yet there is still a lack of understanding as to which specific circuits to rewire for the best results. Fortunately, a new method called SLICE, which has been described […]
November 19, 2018

Is zinc the link to how we think? Some evidence, and a word of warning

In biology, structure equals function. The protein machines that do virtually all of the myriad biochemical jobs within every living cell sometimes require the presence of a molecule or two of an elemental substance — copper, iron, manganese, chromium, or what have you — so they can assume just the […]
November 19, 2018

Rainforest vine compound starves pancreatic cancer cells

Pancreatic cancer cells are known for their ability to thrive under extreme conditions of low nutrients and oxygen, a trait known in the cancer field as “austerity.” The cells’ remarkable resistance to starvation is one reason why pancreatic cancer is so deadly. Now researchers have identified a compound from a […]
November 19, 2018

Vital Insights

For years, it’s remained an open question: What effects do dietary supplements such as high doses of vitamin D or omega-3 fatty acids derived from fish oil have on the risk of diseases such as heart attack, stroke and cancer? While there have been hints along the way, until now, […]
November 19, 2018

Activating a new understanding of gene regulation

Regulation of gene expression — turning genes on or off, increasing or decreasing their expression — is critical for defining cell identity during development and coordinating cellular activity throughout the cell’s lifetime. The common model of gene regulation imagines the nucleus of the cell as a large space in which […]
November 16, 2018

Cognitive Decline After Radiation Therapy for Brain Tumors Might Be Prevented By Temporarily Shutting Down Immune Response

Treating brain tumors comes at a steep cost, especially for children. More than half of patients who endure radiation therapy for these tumors experience irreversible cognitive decline, a side-effect that has particularly damaging consequences for younger patients. Up to now, scientists had been unable to test potential strategies to prevent […]
November 16, 2018

Racial Disparities in Sudden Cardiac Death Rates Cannot Be Explained by Known Risk Factors

While it’s well reported that black patients are twice as likely as white patients to succumb to sudden cardiac death (SCD), the underlying factors that propel this disparity remain unknown. According to a first-of-its-kind study from Penn Medicine, published online in the Journal of the American College of Cardiology, researchers showed that even […]
November 16, 2018

Less Surveillance Needed for Simple Ovarian Cysts

Simple ovarian cysts are extremely common in women and do not require additional ultrasound surveillance or surgical removal, according to a new study of more than 72,000 women and close to 119,00 pelvic ultrasound exams over a dozen years. The study, a collaboration between UC San Francisco and Kaiser Permanente Washington, found that simple cysts are normal, extremely common in both pre- […]
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