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Klotho is one of the few well-established longevity-associated genes that works in both directions in animal models: less klotho shortens life span, while more klotho extends life. Klotho also improves cognitive function. The mechanisms by which klotho produces these outcomes remain poorly understood: there is the usual grab-bag of identified […]

Loss of muscle mass and strength in astronauts remains an issue for space exploration. Caenorhabditis elegans (C. elegans), a nematode species that is 1 mm long, shares common traits with humans and these worms are a good, cost-effective model for studying the effects of spaceflight on muscle. A NASA-funded research team […]

The flexibility of skin, and other elastic tissue such as blood vessel walls, depends upon the structural arrangement of elastin in the extracellular matrix. Elastin is largely laid down during the developmental period of life, and not much repaired thereafter. Disruption of this structure is progressive over time, and is […]

Inhibitory neurons target the weakest-responding neurons in the brain to facilitate transmission of signals. When looking at a complex landscape, the eye needs to focus in on important details without losing the big picture—a charging lion in a jungle, for example. Now, a new study by Salk scientists shows how […]

Salk scientists find that canopy shade from competing plants triggers cellular changes in as little as five minutes. Scientists and gardeners have long known that plants grow taller and flower sooner when they are shaded by close-growing neighbors. Now, for the first time, researchers at the Salk Institute have shown […]

Researchers have for some years proposed reprogramming of scar tissue cells in the injured heart as a way to produce a regrowth of healthy tissue, an outcome that does not normally occur. The heart is one of the least regenerative organs in mammals, and injury produces scarring and loss of […]

New research shows cells gather more data than once believed inside the thalamus, a relay station of sensory and motor abilities in the brain. That could change how medicine treats schizophrenia, epilepsy and other brain disorders. Our brains are responsible for coordinating and interpreting many of the actions we take […]

Linked to serious health problems including cancer, diabetes and cardiovascular disease, obesity affects more than a third of adults in the United States. Presently, there are few safe and effective nonsurgical therapeutic interventions available to patients with obesity.  Now, a multi-disciplinary team of researchers has demonstrated that a metabolic regulatory […]

Biomarkers are important determinants of appropriate and effective therapeutic approaches for various diseases including cancer. There is ample evidence pointing toward the significance of immune check point inhibitors (ICI) against cancer, and they showed promising clinical benefits to a specific group of patients with colorectal cancer (CRC). Several reports demonstrated […]