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Tendon injuries in sheep that were treated with stem cell grafts achieved, in just two months, a diameter and hardness similar to the original healthy tendon, according to the results of a study released in STEM CELLS Translational Medicine (SCTM). These findings suggest that the treatment, which uses autologous adipose […]

Scientists from Queen Mary University of London and UCL have shown that fetal membranes are able to heal after injury in a new study published in Scientific Reports. The integrity of the fetal membranes that surround the baby in the womb during pregnancy is vital for normal development. But fetal […]

Immunotherapy works by stimulating the body’s natural defence system to attack cancer. Currently, all antibody drugs used for cancer belong to an antibody type called IgG, but this new drug – called MOv18 IgE – is designed as an IgE type antibody. The reasoning behind the decision to study this […]

Most of what to my eyes are less promising lines of research into the treatment of aging are focused on manipulation of cellular metabolism. These approaches, such as targeting the mTOR pathway, largely derive from the study of calorie restriction and the cellular response to stress that is brought on […]

Deep learning methods help researchers to predict cancer subtypes or disease progression estimation. However, existing models process an entire set of genes. A recent study on arXiv.org proposes to take advancements in natural language processing and generate a dynamic representation of features from self-attention-based architectures. The approach emphasizes only the […]

Throughout development, life and the processes of aging, all human cells accumulate mutations, resulting in what is called mosaicism, a condition in which different cells in the same person have different DNA sequences or genetic makeup. Mosaicism occurs in every human but is mostly unnoticeable. If abnormal cells begin to […]

Why we sleep, and the processes behind sleep, are amongst the most interesting questions in modern neuroscience. Researchers at the University of Oxford have now uncovered a new target for sleep investigations within the mammalian brain – the cerebral cortex. The paper was published in Nature Neuroscience. The cerebral cortex […]

Bioengineers at the University of California San Diego have developed a cancer immunotherapy that pairs ultrasound with cancer-killing immune cells to destroy malignant tumors while sparing normal tissue. The new experimental therapy significantly slowed down the growth of solid cancerous tumors in mice. The team, led by the labs of […]

Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system. Apart from dynamic periods when the brain is learning new information or skills, the number of the “glutamatergic” synapses, the major […]

Obtaining two vaccine doses remains the most effective way to ensure protection against the COVID-19 Delta variant of concern dominant in the UK today, according to a study from the University of Oxford. Conducted in partnership with the Office of National Statistics (ONS) and the Department for Health and Social […]

Since the early days of the COVID pandemic, scientists have aggressively pursued the secrets of the mechanisms that allow severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter and infect healthy human cells. Early in the pandemic, University of California San Diego’s Rommie Amaro, a computational biophysical chemist, helped develop […]

Researchers report that infantile spasms, a rare but serious seizure disorder in babies, appear to be the result of a molecular pathway gone awry. In their study of a mouse model of the disorder, the researchers discovered that genetic mutations associated with the disease impair a pathway that is involved […]

Cambridge scientists have grown beating heart cells in the lab and shown how they are vulnerable to SARS-CoV-2 infection. In a study published in Communications Biology, they used this system to show that an experimental peptide drug called DX600 can prevent the virus entering the heart cells. The heart is one […]

Hematopoietic stem cells — the precursors to blood cells — have been notoriously difficult to grow in a dish, a critical tool in basic research. Scientists at University of California San Diego School of Medicine have identified the underlying issue and developed a method to keep cultured cells healthy. These […]

IGF-1 is one of the better studied areas of metabolism relevant to determining the pace of aging in a species, involved in the regulation of tradeoffs between growth and sustained function. In the context of the evolution of aging, a mechanism exhibiting antagonistic pleiotropy is beneficial in youth but harmful […]