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Loss of hair cells in the inner ear is thought to be the primary mechanism behind the progression of age-related hearing loss, though there is some debate over whether it is in fact loss of cells versus loss of the connections that link hair cells to the brain. For some […]

Rejuvenation takes place very early in embryonic development. The germline cells that go into the creation of an embryo are well protected and maintained in comparison to the average somatic cell in the adult body. Nonetheless, there is an accumulation of age-related epigenetic changes and molecular damage. Cells purge themselves […]

Much of the communication between cells is carried in extracellular vesicles, membrane-wrapped packages of signaling molecules. Vesicles are classified by size at present, though the nomenclature is often used confusingly and inconsistently. Exosomes are one class of smaller and frequently studied vesicle. Since it is now comparatively cheap to analyze […]

Some people have a tough character and have trouble establishing close relationships with other people. However, sometimes the inability to relate to the environment and others is linked to managing emotions and making decisions. There may be hallucinations or even a complete lack of emotions. In this case, it may […]

The combination of dasatinib and quercetin was the first practical senolytic therapy explored in mice and human trials. Treatments tended to be one-time (a few doses a few days apart) or weekly over a period of a few months. Here, researchers try a longer term approach, weekly intervals for much […]

Every cell in the body goes through thousands of chemical reactions each day, and each reaction involves tiny protein molecules folded into precise shapes to perform their functions. Misfolded proteins underlie some of the most common and devastating diseases of aging, like Alzheimer’s and Parkinson’s. A major focus of aging […]