Related Science News – Page 133 – Innovita Research

Related Science News

October 21, 2020

Reviving cells after a heart attack

Extracellular vesicles (EVs), nanometer-sized messengers that travel between cells to deliver cues and cargo, are promising tools for the next generation of therapies for everything from autoimmune and neurodegenerative diseases to cancer and tissue injuries. EVs have already been shown to help heart cells recover after a heart attack, but […]
October 21, 2020

Axitinib Improves Survival for Patients with Incurable Head and Neck Cancer

This phase 2 trial also identified a subset of patients with specific mutations who may see the most benefit from the drug. When first- and second-line treatments have been exhausted, few options remain for patients with advanced head and neck cancer. A new phase 2 clinical trial by researchers at […]
October 21, 2020

Startup company founded by Washington University scientists acquired by Eli Lilly

Pharmaceutical maker Eli Lilly and Company have purchased Disarm Therapeutics, a startup biotechnology firm founded by researchers at Washington University School of Medicine in St. Louis. Disarm Therapeutics was co-founded by Jeffrey Milbrandt, MD, PhD, and Aaron DiAntonio, MD, PhD, to speed the development of treatments for multiple neurodegenerative conditions. Based […]
October 21, 2020

Targeted delivery of anti-inflammatory therapy shows promise in slowing progression of multiple sclerosis

Intranasal administration of an anti-inflammatory drug helped reduce disease progression in a preclinical model of multiple sclerosis, according to recent research out of the University of Alberta. Christopher Power, a professor in the Faculty of Medicine & Dentistry, and Leina Saito, a graduate student on his team, showed that delivering an anti-inflammatory […]
October 21, 2020

Study reveals significant restoration of retinal and visual function following gene therapy

New generation CRISPR technology lays foundation for therapeutics to treat a wide range of inherited ocular diseases. A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease. Published in Nature Biomedical […]
October 21, 2020

New Study Provides Insight into Early Molecular Changes in Head and Neck Cancer

Large repository of blood samples from military personnel provides invaluable resource for PNNL biomedical scientists Routine serial blood draws during military personnel’s service are proving to be an invaluable bank of specimens for health researchers. Using samples collected at enlistment, every two years for HIV testing, and at pre-deployment and post-deployment, […]
October 20, 2020

Newborn brains lack maturity to process emotions as adults do

Humans aren’t born with mature brain circuitry that attaches emotions to the things they see or hear in their environment, a new study shows. Researchers studying brain scans of newborns found that the part of the brain involved in experiencing emotions isn’t functionally connected in a mature way with the […]
October 20, 2020

CRISPR Meets Pac-Man: New DNA Cut-and-Paste Tool Enables Bigger Gene Edits

Gene editing for the development of new treatments, and for studying disease as well as normal function in humans and other organisms, may advance more quickly with a new tool for cutting larger pieces of DNA out of a cell’s genome, according to a new study by UC San Francisco […]
October 19, 2020

Scientists are getting closer to effective treatment for hair loss

Hair loss seems like a minor problem to many. You got bald, so what? Some people prefer this look. However, for many men going bald is a terrible experience and they would pay good money to avoid it. Now scientists at the University of Helsinki have identified a mechanism that […]
October 19, 2020

Calcium bursts kill drug-resistant tumor cells

Multidrug resistance (MDR) – a process in which tumours become resistant to multiple medicines –– is the main cause of failure of cancer chemotherapy. Tumour cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in […]
October 19, 2020

What Fuels the Beating Heart? Study Reveals Nutrients Used by Normal and Failing Hearts

A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has produced a detailed picture of fuel and nutrient use by the human heart. The study, published in Science, was the first of its kind, involving the simultaneous sampling of blood from different parts […]
October 19, 2020

Engineered Developmental Signals Could Illuminate Regenerative Medicine

For a tiny embryo to develop into an adult organism, its cells must develop in precise patterns and interact with their neighbours in carefully orchestrated ways. To create complex tissues and organs – from the pattern of rods and cones in the retina to the Byzantine filtration systems of the […]
October 18, 2020

Delivery of T Cell Progenitor Cells as an Approach to Thymic Regeneration

The thymus is a small organ in which thymocytes generated in the bone marrow mature to become T cells of the adaptive immune system. Unfortunately, the thymus atrophies with age, its active tissue largely replaced by fat in most people by age 50 or so. Thereafter the adaptive immune system […]
October 18, 2020

Senescent cells may be good when it comes to a bad injury

It’s called senescence, when stressed cells can no longer divide to make new cells, and it’s considered a factor in aging and in some diseases. Now scientists have some of the first evidence that at a younger age at least, senescent cells show up quickly after a major injury and […]
October 17, 2020

To What Degree do Bodily Microbiomes Beyond the Gut Contribute to the Chronic Inflammation of Aging?

Most research on the microbial life of the body in the context of aging is focused on the gut microbiome, though a fair amount of investigation of oral microbial populations also takes place. In both cases, changes occur with age that allow harmful species of microbe to prosper, contributing to […]
October 17, 2020

Fecal Microbiota Transplantation from Old Mice to Young Mice Impairs Cognitive Function

The microbiome of the gut changes with age, and this is presently thought to have a meaningful influence over the course of aging. It is perhaps in the same ballpark as the effects of exercise on the pace of aging and risk of age-related disease, and certainly overlaps with the […]
October 17, 2020

New app helps people watching out for the signs of oncoming dementia

Age-related dementia is in the cards for many. It is an incurable condition, which is one of the worst things about aging. It is debilitating to the patient as well as his entire family. Now scientists at UCL have developed an artificial intelligence based app, which can help screening people […]
October 17, 2020

Incorporating Microelectronics into Bioartificial Blood Vessels

Researchers here report on an interesting proof of concept, incorporating electronic device capabilities into the flexible biomaterials used as scaffolding for blood vessel tissue engineering. As a next generation technology to potentially replace the use of stents in the treatment of cardiovascular disease, bioartificial blood vessel sections are already promising. […]
October 17, 2020

During development, stress fibers help cells keep their shape—and may also regulate size

As organisms develop, mechanical forces exert pressure on their cells, and scientists have long wondered how cells keep their shape—and therefore remain healthy—through the process. Now, a study led in part by a University of Michigan physicist has observed for the first time that cells use tiny fibers called apical […]
October 17, 2020

Counterintuitive discoveries about immune-like characteristics of cells, chemotherapy’s impact on tissue growth

Vanderbilt University researchers have reported the counterintuitive discovery that certain chemotherapeutic agents used to treat tumors can have the opposite effect of tissue overgrowth in normal, intact mammary glands, epidermis and hair follicles. The researchers also are the first to report the discovery of an innate immune signaling pathway in […]
October 17, 2020

Cells on the run

Many cells in the body must pass through tissue, which sometimes requires them to get out of tight corners. An international research team co-​led by ETH Zurich has now examined how cells recognise and escape from such bottlenecks. Among the results of the team’s work are new pointers for how […]
October 16, 2020

In Search of Common Transcriptional Regulators of Aging

Are there common regulators of aging to be found among transcription factors? Sweeping, complex, tissue-specific and species-specific changes in gene expression take place over the course of aging. If these are reactions to comparatively straightforward processes of molecular damage at the root of aging, processes that are similar between species, […]
October 16, 2020

Lamenting the Incomplete Understanding of Human Immunosenescence

The immune system is inconveniently complicated. Aging is also inconveniently complicated. The overlap between the two is a particularly dark forest for the research community, with few well-tracked paths. The fine details of how exactly the immune system becomes dysfunctional with age, and the sizable variation in those details between […]
October 16, 2020

An Example of the Beneficial Role of Senescence in Injury

Researchers here provide an interesting demonstration of the beneficial role of transient cellular senescence in injury. Applying senolytics to selectively destroy senescent cells immediately following traumatic injury greatly worsens the consequences. Senescent cells are harmful when they build up and linger in tissues over the course of later life. The […]
October 16, 2020

Weakened Hearts Linked to a Build-Up of Phosphate

Heart failure is a debilitating condition that impairs quality of life and shortens life span. Rates of heart failure continue to rise to epidemic levels, in parallel with its risk factors—obesity, diabetes, and hypertension. In essence, heart failure is a condition in which the heart has difficulty generating the pumping […]
October 15, 2020

Wearable tech will help people manage multiple sclerosis

U of A researchers, precision health company team up to develop sensor small enough to wear behind the ear but powerful enough to reduce costly hospital visits. University of Alberta researchers are teaming up with a precision-health innovator to develop a low-cost wearable sensor to help people suffering from chronic […]
October 15, 2020

New Research Shows How Nanoparticles Can Turn Off Genes in Bone Marrow

Using specialized nanoparticles, researchers from Penn Engineering and the Massachusetts Institute of Technology (MIT) have developed a way to turn off specific genes in cells of bone marrow, which play an important role in producing blood cells. These particles could be tailored to help treat heart disease or to boost […]
October 15, 2020

Clues to Brain Development and Disease Emerge from 3D Epigenome Study

Risks for neuropsychiatric disorders including autism, schizophrenia and attention deficit hyperactivity disorder (ADHD) are in part genetically determined. Now UC San Francisco researchers are finding new clues to how these disorders unfold by focusing on the role of a little-studied form of DNA in early brain development. Like a late-night […]
October 15, 2020

Harnessing the power of nanobodies to rebuild kidneys

UW Medicine scientists are driving a bold, multi-partner experiment to stimulate the repair and regeneration of human kidney cells. A favorable outcome could jump-start a new therapy model for 850 million people worldwide who live with kidney disease. The National Institutes of Health recently announced the project’s funding: $4 million over five […]
October 15, 2020

Study: Racial disparities exist in cognitive health expectancies, despite educational attainment

There are more than 5 million Americans living with Alzheimer’s disease, and 50 million with other dementias, according to figures from the Alzheimer’s Association. Research into these diseases and how to prevent them is key as more and more Americans live longer, raising their risk for developing cognitive impairment. In a new […]