Related Science News – Page 109 – Innovita Research

Related Science News

March 4, 2020

Salk scientists show how caloric restriction prevents negative effects of aging in cells

If you want to reduce levels of inflammation throughout your body, delay the onset of age-related diseases and live longer—eat less food. That’s the conclusion of a new study by scientists from the US and China that provides the most detailed report to date of the cellular effects of a […]
March 4, 2020

Boosting energy levels within damaged nerves may help them heal

NIH-funded project in mice provides insights into why nerves fail to regrow following injury. When the spinal cord is injured, the damaged nerve fibers — called axons — are normally incapable of regrowth, leading to permanent loss of function. Considerable research has been done to find ways to promote the […]
March 4, 2020

Illuminating the Athletic Aorta

It’s long been known that endurance athletes have larger hearts on average than the rest of the population and that cardiac enlargement is a healthy adaptation to exercise. But what wasn’t known until now was whether the aorta—the main artery leaving the heart and supplying the body with oxygenated blood—followed […]
March 3, 2020

Scientists discover new “Jekyll and Hyde” immune cell

Scientists from Trinity have identified a rare, new cell in the immune system with “Jekyll and Hyde properties”. These cells play a key protective role in immunity to infection but – if unregulated – also mediate tissue damage in autoimmune disorders. The findings should help us design more effective vaccines […]
March 3, 2020

Presence of Staph Bacteria in Skin Microbiome Promotes Netherton Syndrome Inflammation

Netherton syndrome, a rare skin disease caused by a single genetic mutation, is exacerbated by the presence of two common Staphylococcal bacteria living on human skin, one of which was previously thought to only offer protective properties, report University of California San Diego School of Medicine researchers. “Our study shows how closely […]
March 3, 2020

Research identifies how new cancer treatments can activate tuberculosis infection

Researchers at the University of Southampton have identified how new checkpoint inhibitor treatments for cancer can activate tuberculosis in some patients. Immune therapies for cancer are transforming treatment by activating the body’s immune cells to fight off cancer. Immune checkpoints are part of the human body’s immune system that prevent […]
March 3, 2020

Scientists show drug may greatly improve cancer immunotherapy success

A study led by the University of Southampton, funded by Cancer Research UK, has shown a new drug – originally developed to tackle the scarring of organ tissue – could help to significantly improve the success rate of cancer immunotherapy treatment. Scientists have shown in mouse cancers, that GKT137831 (Setanaxib) […]
March 3, 2020

Brain immune cells, neurodegeneration differ in males, females

Immune cell activity in the brain differs between males and females in ways that may explain why some neurodegenerative diseases affect the sexes differently, according to a new study from Weill Cornell Medicine scientists. Dr. Li Gan, the Burton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases in […]
March 3, 2020

Egg stem cells do not exist, new study shows

Researchers at Karolinska Institutet in Sweden have analysed all cell types in the human ovary and found that the hotly debated so-called egg stem cells do not exist. The results, published in Nature Communications, open the way for research on improved methods of treating involuntary childlessness. The researchers used single-cell […]
March 3, 2020

Blood test method may predict Alzheimer’s protein deposits in brain

Researchers report an advance in the development of a blood test that could help detect pathological Alzheimer’s disease in people who are showing signs of dementia. This approach could be less invasive and less costly than current brain imaging and spinal fluid tests. The blood test detects the abnormal accumulation […]
March 3, 2020

Blood Test Can Predict Clinical Response to Immunotherapy in Metastatic Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations. A clinical trial led by researchers from the Perelman School of Medicine at the […]
March 3, 2020

New Blood Test Could Make Alzheimer’s Diagnosis Easier Than Ever

A simple blood test may soon be able to diagnose patients with two common forms of dementia – Alzheimer’s disease and frontotemporal dementia (FTD) – and tell the two apart. Researchers at UC San Francisco analyzed the blood test in more than 300 patients and say they hope to see […]
March 3, 2020

Study: AI improves radiologists’ readings of mammograms

Machine-learning algorithms could help improve the accuracy of breast cancer screenings when used in combination with assessments from radiologists, according to a study published in JAMA Network Open. The study was based on results from the Digital Mammography (DM) DREAM Challenge, a crowd-sourced competition to engage an international scientific community to assess whether […]
March 3, 2020

Study underscores importance of molecular highways for organ health

Turns out, even your cells hate traffic jams. In order for cells to function properly, they need to be able to coordinate traffic within their walls and let information flow in and out. Inside a cell, molecules, organelles and information travel along microtubules, which work like highways or conveyor belts. […]
March 2, 2020

Research reveals link between high cholesterol levels and risk of aortic valve disease

Researchers from The George Institute for Global Health at the University of Oxford have found that while having high cholesterol levels does not influence your risk of aortic or mitral valve regurgitation, it does increase your risk of developing another major heart valve disease – aortic stenosis. Aortic stenosis is […]
March 2, 2020

New chemo combo shows promise versus pancreatic cancer

The targeted drug palbociclib may boost the effectiveness of chemotherapy in pancreatic cancer if the two treatments are given in the right sequence, according to new preclinical research by Weill Cornell Medicine and NewYork-Presbyterian investigators. The study, published in Cancer Cell, found that palbociclib may stop pancreatic cancer cells from repairing […]
March 2, 2020

Stable conditions during cell division

Errors during cell division can trigger the development of cancer. No wonder that this central process is controlled by multiple regulators and guards. Alex Bird's research group at the Max Planck Institute of Molecular Physiology has discovered a hitherto unknown key player and how it provides the necessary stability to […]
March 2, 2020

New Cas9 variant makes genome editing even more precise

CRISPR-Cas9 has revolutionized the field of genetics by its ability to cut DNA at defined target sites. Researchers are using the Cas9 enzyme to specifically switch off genes, or insert new DNA fragments into the genome. But no matter how specific the Cas9 enzyme is – sometimes it cuts where […]
March 2, 2020

A weak heart also damages the brain

If the heart pumps too little blood into the body, the brain is usually not adequately supplied with oxygen. Until now, however, it was unclear how this affects brain structure. Researchers at the Max Planck Institute for Human Cognitive and Brain Sciences together with colleagues from the Leipzig Heart Clinic, […]
March 2, 2020

An Epigenetic Clock for Skeletal Muscle

Epigenetic clocks are multiplying year by year. Each is a weighted algorithmic combination of the status of various methylation sites on the genome, built by analyzing the epigenome of many different people at different ages in order to arrive at correlations with chronological age, or, more usefully, with metrics such as mortality risk that reflect biological […]
March 2, 2020

Length of pregnancy alters the child's DNA

Researchers from Karolinska Institutet led by Professor Erik Melén have together with an international team mapped the relationship between the length of pregnancy and chemical DNA changes in more than 6,000 newborn babies. For each week's longer pregnancy, DNA methylation changes in thousands of genes were detected in the umbilical […]
March 2, 2020

New probe developed to detect a common target for anti-inflammatory drugs

Scientists have developed a probe named CoxFluor that can distinguish between Cyclooxygenase-2, an enzyme that plays a major role in driving the progression of cancer, and the enzyme Cyclooxygenase-1, which is expressed in all cells. Led by Jefferson Chan, a chemist at the University of Illinois at Urbana-Champaign, a paper detailing […]
March 2, 2020

Fasting at night or in the morning? Listen to your biological clock, says new research

In recent years, diet trends such as Intermittent Fasting have popularized the practice of delayed or restricted eating for many individuals looking to manage caloric intake. Still, many people open to restructuring their schedules have the same question: When is the right time to avoid eating? According to a new […]
March 2, 2020

Intensive Blood Pressure Control Can Extend Life up to Three Years

A new study by investigators at Brigham and Women’s Hospital puts the results of a landmark trial about blood pressure control into terms that may be easier to interpret and communicate to patients. When data from The Systolic Blood Pressure Intervention Trial (SPRINT) were published in 2015, the medical community responded enthusiastically […]
March 2, 2020

Widowhood Accelerates Cognitive Decline Among Those at Risk for Alzheimer's Disease

The death of a spouse often means the loss of intimacy, companionship and everyday support for older adults. A new study finds that widowhood can have another profound effect: It may accelerate cognitive decline. Investigators from Brigham and Women’s Hospital and Massachusetts General Hospital analyzed older, cognitively normal Americans enrolled […]
March 2, 2020

Study suggests way to improve cytomegalovirus testing

Many tests for cytomegalovirus infection are difficult to interpret because most of its DNA fragments are too small to be detected in the blood of infected people through current assays.  Laboratory medicine experts at the University of Washington School of Medicine are looking at this problem to find better ways […]
February 29, 2020

Resetting the Biological Clock with Flip of the Molecular Switch

Scientists from UC San Diego, UC Santa Cruz and Duke University synchronized their research watches to study what makes our biological clocks tick. Specifically they set out to understand why some people are what they call extreme “morning larks” who operate on a shorter 20-hour cycle compared to a regular 24-hour pattern. […]
February 28, 2020

Parental use of digital media gives slower language development in children

A research project at Linköping University has shown that children whose parents often use digital media develop language more slowly than others. For three years, Associate Professor Anett Sundqvist and her research group in the Child and Infant Lab at Linköping University have studied young children and their development in […]
February 28, 2020

A molecular atlas of skin cells

Our skin protects us from physical injury, radiation, and microbes, and at the same time produces hair and facilitates perspiration. Details of how skin cells manage such disparate tasks have so far remained elusive. Now, researchers at Karolinska Institutet in Sweden have systematically mapped skin cells and their genetic programs, […]
February 28, 2020

Breast cancer study may help predict treatment response

Researchers at Vanderbilt University Medical Center are reporting another advance in the understanding and treatment of triple-negative breast cancer, which is particularly aggressive and difficult to treat. Their findings, detailed in the journal Clinical Cancer Research, offer new hope for identifying patients most likely to respond to the latest treatments. “This […]