Related Science News – Page 42 – Innovita Research

Related Science News

August 19, 2020

These Drugs Carry Risks and May Not Help, But Many Dementia Patients Get Them Anyway

Nearly three-quarters of older adults with dementia have filled prescriptions for medicines that act on their brain and nervous system, but aren’t designed for dementia, a new study shows. That’s despite the special risks that such drugs carry for older adults – and the lack of evidence that they actually ease […]
August 19, 2020

Genomics data to enable critical brain and mitochondrial research

A Garvan-developed platform is providing researchers access to genomic data that will help drive discoveries in severe mitochondrial and brain disorders. Medical researchers from across the globe will gain new insight into some of the most devastating inherited conditions, thanks to anonymized genomic and clinical summary data made available by […]
August 18, 2020

Cell diversity in the embryo

A research team at the Max Planck Institute for Molecular Genetics in Berlin has explored the role of factors in embryonic development that do not alter the sequence of DNA, but only epigenetically modify its “packaging”. In the scientific journal Nature, they describe how regulatory mechanisms contribute to the formation of […]
August 18, 2020

Four-stranded DNA structures found to play role in breast cancer

Four-stranded DNA structures – known as G-quadruplexes – have been shown to play a role in certain types of breast cancer for the first time, providing a potential new target for personalised medicine, say scientists at the University of Cambridge. In 1953, Cambridge researchers Francis Crick and James Watson co-authored […]
August 18, 2020

Study suggests embryos could be susceptible to coronavirus as early as second week of pregnancy

Genes that are thought to play a role in how the SARS-CoV-2 virus infects our cells have been found to be active in embryos as early as during the second week of pregnancy, say scientists at the University of Cambridge and the California Institute of Technology (Caltech). The researchers say […]
August 18, 2020

The behaviour of therapeutic antibodies in immunotherapy

Since the late 1990s, immunotherapy has been the frontline treatment against lymphomas where synthetic antibodies are used to stop the proliferation of cancerous white blood cells. However, in the more than 20 years since their use began, the molecular mechanisms that underlie this therapy are still little understood. For the […]
August 18, 2020

Brace yourself for these results: isolating genes that cause some people to gain muscle while others don’t

Researchers studying the mystery of why some weightlifters’ muscles grow much more quickly than others’ have found new answers through a novel experiment in which subjects worked out one leg and immobilized the other. In just two weeks, the immobilized leg, on average, lost the same amount of muscle mass […]
August 18, 2020

Flipping a Metabolic Switch to Slow Tumor Growth

The enzyme serine palmitoyl-transferase can be used as a metabolically responsive switch that decreases tumor growth, according to a new study by a team of San Diego scientists, who published their findings in the journal Nature. By restricting the dietary amino acids serine and glycine, or pharmacologically targeting the serine […]
August 18, 2020

Extrachromosomal DNA is common in human cancer and drives poor patient outcomes

The multiplication of genes located in extrachromosomal DNA that have the potential to cause cancer drives poor patient outcomes across many cancer types, according to a Nature Genetics study published by a team of researchers including Professors Vineet Bafna and Dr. Paul Mischel of the University of California San Diego  […]
August 18, 2020

Should Rapamycin be Prescribed Ubiquitously as an Anti-Aging Supplement?

Should rapamycin be prescribed ubiquitously as an anti-aging supplement? That is the question the authors of this commentary ask after a short overview of what is known of the beneficial effects of rapamycin on mechanisms relevant to aging. Research into inhibition of the two mTOR complexes, mTORC1 and mTORC2, via […]
August 18, 2020

Gene targeting helps overcome the resistance of brain cancer to therapy

New insight into a gene that controls energy production in cancer stem cells could help in the search for a more effective treatment for glioblastoma. A McGill-led study published in Nature Communications reveals that suppressing the OSMR gene can improve the effectiveness of radiation therapy. This approach, led by the laboratory of […]
August 18, 2020

Autism-Cholesterol Link

New research reveals a subtype of autism associated with lipid abnormalities. Researchers at Harvard Medical School, Massachusetts Institute of Technology and Northwestern University have identified a subtype of autism arising from a cluster of genes that regulate cholesterol metabolism and brain development. The researchers say their findings, published in Nature […]
August 18, 2020

New pediatric sleep disorder defined

Children suffering from restless sleep disorder would report trouble focusing during the day, and emotional and behavioral problems at home and school. A UW Medicine researcher, along with colleagues from Italy, Spain and Chile, have defined a new pediatric sleep disorder, which once diagnosed and treated, may help children and […]
August 17, 2020

Reviewing Associations Between Physical Activity and Loss of Average Telomere Length with Age

Telomeres are repeated DNA sequences at the ends of chromosomes. With each cell division a little telomere length is lost, and this is an important part of the countdown mechanism that limits replication of somatic cells. Somatic cells with short telomeres become senescent or self-destruct. Stem cells, on the other […]
August 17, 2020

Seasonal flu vaccinations don’t 'stick' long-term in bone marrow

A study from Emory Vaccine Center provides insights into why the boost in immunity from seasonal flu vaccination lasts for months but not years, unlike some childhood vaccinations. The home base for immune cells that produce antibodies is the bone marrow. Seasonal flu vaccination does increase the number of antibody-producing […]
August 17, 2020

New diagnostic criteria shine light on early dementia mimics

Experts estimate up to one third of people attending specialist memory clinics could have a condition that is commonly mistaken for early dementia. In a paper published in the journal, Brain, UK academics and clinicians have collaborated to develop a diagnostic definition of the widely recognized but poorly understood condition, Functional Cognitive Disorder (FCD).  Dr Harriet Ball from the University of Bristol, first author of the […]
August 17, 2020

Key gene identified for improving MS treatment

The disease multiple sclerosis (MS) attacks the central nervous system and, with time, can give rise to muscle tremors and loss of balance. Researchers at Karolinska Institutet have now identified a gene, Gsta4, that protects a certain kind of cell in the brain from being destroyed. It is hoped that […]
August 17, 2020

Scientists Demonstrate How Genetic Variations Cause Eczema

New research supported by the National Institutes of Health delineates how two relatively common variations in a gene called KIF3A are responsible for an impaired skin barrier that allows increased water loss from the skin, promoting the development of atopic dermatitis, commonly known as eczema. This finding could lead to genetic tests […]
August 16, 2020

Reviewing the Mechanisms of Longevity in Long-Lived Bats

Today's open access research is a good companion piece to a recent paper that investigates biochemical differences between long-lived and short-lived bats. Bats are renowned for, firstly, an exceptional resistance to classes of virus that are fatal to other mammals, allowing bat populations to act as reservoirs for potentially dangerous […]
August 14, 2020

Study guides next generation of advanced ER+ breast cancer therapy

In a proof-of-principle study, researchers at the Garvan Institute of Medical Research revealed a potential therapeutic approach for targeting estrogen receptor-positive (ER+) breast cancers resistant to current therapies. By combining current gold-standard treatments with a drug that restores the activity of p53, a cancer suppressor protein, the researchers found they […]
August 14, 2020

Breast cancer ‘ecosystem’ reveals possible new targets for treatment

Researchers from the Garvan Institute of Medical Research have uncovered four new subtypes of cells within triple negative breast cancer, which contain promising new therapeutic targets for the aggressive disease. Using cellular genomics, the team revealed one of the new cell types produces molecules that suppress immune cells, which may […]
August 14, 2020

Algorithm created by deep learning finds potential therapeutic targets throughout the human genome

Researchers at the New Jersey Institute of Technology and the Children's Hospital of Philadelphia have developed an algorithm through machine learning that helps predict sites of DNA methylation — a process that can change the activity of DNA without changing its overall structure. The algorithm can identify disease-causing mechanisms that would otherwise […]
August 14, 2020

Study Suggests New Potential Approach Against Fatal Childhood Brain Cancer

Progress against DIPG, a fatal childhood brain tumor, is usually a game of inches. Studies that hint at even small gains are cause for celebration. That’s why researchers at the University of Michigan and their collaborators are excited about discoveries that point toward a new potential treatment approach — one […]
August 14, 2020

Aspirin Caution

The results of a recent clinical trial indicate that, for older adults with advanced cancer, initiating aspirin therapy may increase their risk of disease progression and early death. Notably, the vast majority of the study participants did not previously take aspirin before age 70. The study, conducted by Harvard Medical […]
August 14, 2020

Exercise Enhancement

Loss of a specific enzyme increases fat metabolism and exercise endurance in mice. Sugars and fats are the primary fuels that power every cell, tissue, and organ. For most cells, sugar is the energy source of choice, but when nutrients are scarce, such as during starvation or extreme exertion, cells […]
August 13, 2020

Research captures how human sperm swim in 3D

Using state-of-the-art 3D microscopy and mathematics, Dr. Hermes Gadêlha from the University of Bristol, Dr. Gabriel Corkidi, and Dr. Alberto Darszon from the Universidad Nacional Autonoma de Mexico have reconstructed the movement of the sperm tail in 3D with high-precision. Using a high-speed camera capable of recording over 8,000 frames […]
August 13, 2020

Unlocking how cellular proteins control cancer spread

A new insight into cell signals that control cancer growth and migration could help in the search for effective anti-cancer drugs. A McGill-led study reveals key biochemical processes that advance our understanding of colorectal cancer, the third most common cancer among Canadians. Using the CMCF beamline at the Canadian Light Source (CLS) […]
August 13, 2020

Study reveals immune-system deviations in severe COVID-19 cases

Some people get really sick from COVID-19, and others don’t. Nobody knows why. Now, a study by investigators at the Stanford University School of Medicine and other institutions has turned up immunological deviations and lapses that appear to spell the difference between severe and mild cases of COVID-19. That difference may stem […]
August 13, 2020

Oxygen Therapy Harms Lung Microbiome in Mice

One of the hallmarks of severe COVID-19 is shortness of breath and significantly reduced levels of oxygen in the blood, called hypoxemia. Upon hospitalization, these patients are administered oxygen in an attempt to bring their levels back up to normal. However, a new study hints that this universal therapy may […]
August 13, 2020

Prostate Cancer Treatment Might Help Some Glioblastoma Patients

Anti-androgens are known to increase the effectiveness of radiation therapy for prostate cancer patients, helping to slow the rate at which cancer can repair DNA damage caused by the treatment. Could the same strategy work against glioblastoma, an aggressive brain cancer that quickly grows resistant to radiation? Research led by […]