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In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity. In a new study, researchers from the Institut Pasteur, INSERM(1) and Université Paris Cité describe the mechanisms that modify the […]

Salk scientists improve liver regeneration in mice, which could lead to new treatments for liver disease Mammals can’t typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, Salk scientists have found a way to partially reset liver cells to more youthful states—allowing them to heal […]

Gut microbiota by-products circulate in the bloodstream, regulating host physiological processes including immunity, metabolism and brain functions. Scientists from the Institut Pasteur (a partner research organization of Université Paris Cité), Inserm and the CNRS have discovered that hypothalamic neurons in an animal model directly detect variations in bacterial activity and […]

Going to space changes a person. We've known that ever since NASA and the former Soviet Union started sending people to space back in the mid-20th Century. Not only does that trip affect an astronaut's outlook (just look what it did to William Shatner) but it changes their body. Space […]

The in-built cellular process of maintaining the health of our cells by recycling dead or toxic material plays a key role in our health overall. Known as autophagy, researchers are now keen to know if boosting the natural process may hold off the debilitating diseases of old age. By intervening […]