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Today's open access review paper is a high level look at what the newfound realization of the importance of senescent cells to aging and age-related disease means for the treatment of chronic kidney disease. At present there are few good options for treatment, and those therapies that are widely used […]

For centuries, humans have blamed the moon for our moods, accidents and even natural disasters. But new research indicates that our planet’s celestial companion impacts something else entirely — our sleep. In a paper published in Science Advances, scientists at the University of Washington, the National University of Quilmes in Argentina […]

For the second time, cancer researchers at Vanderbilt have discovered a protein that—when genetically manipulated to impede it from interacting with a gene responsible for cancer genesis—effectively melts tumours in days.  The article, “MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1,” was published in the […]

Organelles continue to thrive after the cells within which they exist die, a team of University of Bristol scientists have found, overturning previous assumptions that organelles decay too quickly to be fossilised. As described in the journal Sciences Advances, researchers from Bristol’s School of Earth Sciences were able to document the […]

The state-of-the-art silica glass optical fibres can carry light signals over tens of kilometres with very low optical loss and provide high-capacity communication networks. However, their brittleness, low stretchability and energy intensiveness make them less suitable for local short-range applications and devices such as automotive, digital home appliances, fabrics, laser […]

Porphyrins are interesting drug delivery vehicles that can specifically accumulate in cancer cells. However, how the structure of the drug-conjugated porphyrin affects its ability to penetrate and accumulate within cancer cells is not well understood. Researchers from the Tokyo University of Science now investigate the correlation between the structure and […]

To catch cancer earlier, we need to predict who is going to get it in the future. The complex nature of forecasting risk has been bolstered by artificial intelligence (AI) tools, but the adoption of AI in medicine has been limited by poor performance on new patient populations and neglect to racial minorities. […]

There are billions of humans on this earth, and each of us is made up of trillions of cells. Just like every individual is unique, even genetically identical twins, scientists observe differences between the genetically identical cells in our bodies. Differences in the location of proteins can give rise to […]

Thanks to modern artificial intelligence technology, researchers at the UC Davis MIND Institute have recently succeeded in accurately predicting the risk of Autism Spectrum Disorder (ASD) on the basis of specific patterns of maternal auto-antibodies, i.e., antibodies that attack the tissues of their own hosts. “The implications from this study […]

Scientists design a novel 3D cell culture-based electrical platform for high-throughput anti-cancer drug testing using a new type of gold nanostructure. Brain cancer is one of the deadliest forms of cancer with poor treatability. Now, scientists from Korea and China have developed a multi-functional platform using gold nanostructures that allows […]

Intermittent fasting (such as alternate day fasting) is not as effective as calorie restriction (consistent reduction in calories every day) in extending life span in animal models such as mice, but it does have many of the same effects on health and longevity. Even when total calorie intake is held […]

How do cis-regulatory genome elements regulate gene expression, what are the critical components involved, and can we therapeutically target them? By investigating how corepressors modulate enhancers and silencers during inflammatory macrophage activation, BioNut researchers have found some unexpected answers to these fundamental questions. The study is published in Molecular Cell. […]

How cells develop and the diseases that arise when development goes wrong have been a decades-long research focus in the laboratory of Distinguished Professor of Biology Ellen Rothenberg. In particular, the lab studies the development of immune cells known as T cells, which act as “intelligence agents”—they circulate throughout the body, […]

An individual's personality does not lie in their behavior or their genes but in the brain, according to a new theoretical study. Do you value courage and bravery or intelligence and learning? Your answer may indicate whether you end up in Gryffindor or Ravenclaw, according to a Harry Potter-themed personality […]

University of Alberta researchers have taken another step forward in developing an artificial intelligence tool to predict schizophrenia by analyzing brain scans. In recently published research, the tool was used to analyze functional magnetic resonance images of 57 healthy first-degree relatives (siblings or children) of schizophrenia patients. It accurately identified the […]

Researchers in the Blavatnik Institute at Harvard Medical School have pieced together the near-atomic structures of a pair of proteins crucial for B cell function—immune cells that produce antibodies and remember how to fight specific invaders long after infection. The work provides invaluable details that may guide the design of […]

Contrary to previous findings, low-dose aspirin therapy before conception and during early pregnancy may increase pregnancy chances and live births among women who have experienced one or two prior miscarriages, suggests a study by researchers at the National Institutes of Health. Rather than looking solely at the difference in pregnancy […]

Pioneering research into how our bodies manufacture the cells that make blood has moved us closer to regrowing tissues and organs. The findings also may let doctors grow cells for transplantation into people to battle cancer, blood disorders and autoimmune diseases. Researcher Karen K. Hirschi of the University of Virginia’s […]

The University of Missouri Research Reactor (MURR®) has entered into an exclusive multi-year agreement with Advanced Accelerator Applications International, SA (AAA), a Novartis company, to provide a key ingredient in a targeted therapy for certain types of cancerous tumors. The agreement covers medical markets in the U.S. and around the […]

The mainstream of the scientific community has for decade after decade followed an entirely incorrect strategy in the matter of aging, and it was only comparatively recently that this state of affairs was changed for the better by the advocacy of groups like the SENS Research Foundation, Methuselah Foundation, and […]

Heart disease deaths have declined among older people, but the trend is less encouraging among younger people, particularly women. Indeed, research suggests that heart disease and death rates from heart disease in these younger groups have remained unchanged or have even gone up slightly. To understand which factors put younger […]

Every living organism has DNA, and every living organism engages in DNA replication, the process by which DNA makes an exact copy of itself during cell division. While it’s a tried-and-true process, problems can arise. Break-induced replication (BIR) is a way to solve those problems. In humans, it is employed chiefly […]

Scientists have very precise instruments, but measuring properties of tiny little cells is still very difficult. Now researchers at the University of Queensland have developed a new tool to measure heat transfer inside living cells. It includes actual diamonds and it can work as both a heater and a thermometre. […]

Brain stimulation is a relatively new way to treat various neurological conditions. It is typically an invasive procedure because electrodes need to be implanted in the brain. However, now scientists at UCL have found a way to use non-invasive brain stimulation to ease tremors typically found in conditions such as […]

Macrophages – immune cells that both fight infections and fix the damage they cause – are often placed into two categories: those that increase inflammation (known as “M1”) to attack, and those that decrease inflammation to begin the healing process (“M2”). Researchers in the lab of Kathryn Miller-Jensen, associate professor […]

Scientists have identified a key factor in mental aging and shown that it might be prevented or reversed by fixing a glitch in the immune system’s front-line soldiers. Suppose Smokey Bear were to lose it and start setting forest fires instead of putting them out. That roughly describes the behaviour […]

A new study suggests that a lot of people might be going through life with symptoms that resemble concussion – a finding supporting researchers’ argument that athletes recovering from a brain injury should be assessed and treated on a highly individualized basis. In the national study, between 11% and 27% […]

When cancer is confined to one spot in the body, doctors can often treat it with surgery or other therapies. Much of the mortality associated with cancer, however, is due to its tendency to metastasize, sending out seeds of itself that may take root throughout the body. The exact moment […]

If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function. Molecular circadian “clocks” exist in cells throughout the body, governing more than just sleep and wake cycles — they are crucial to many aspects of […]

Exposure to mutagens, or mutation-causing agents, can not only bring about changes in DNA but also appear to induce errors when genes are transcribed to make proteins, which may be an important factor in age-related diseases. USC Leonard Davis School of Gerontology Assistant Professor Marc Vermulst and colleagues made the discovery by […]