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Researchers here discuss the distinguishing features of senescent cells and known ways to target those features in order to selectively destroy these cells. Senescent cells accumulate with age throughout the body, likely the consequence of an accelerated pace of creation and a slower pace of destruction by the immune system. […]

Trillions of benign bacteria live in the intestine. They are kept in a continuous balance by the immune system, which thereby makes them harmless to humans. Researchers in the Department for BioMedical Research (DBMR) at the University of Bern and Inselspital, Bern University Hospital, and German Cancer Research Center have […]

A number of companies and research groups are performing drug discovery by using effects on frailty in mice as a readout. To what degree is frailty an adequate measure of the harms done by aging? One way to answer that question is to assess mortality in a human study population […]

It is very hard to coax a damaged machine into continued operation without repairing the damage. It is expensive and time-consuming, the machine works poorly, and fails catastrophically only a little later than it would have done without all of that effort. Keeping damaged machines running is exactly the goal […]