Related Science News – Page 40 – Innovita Research

Related Science News

April 30, 2021

Research will test more sensitive ways to diagnose rare diseases

Adding RNA sequencing to current genetic methods could help diagnose and treat thousands of patients with mystery diseases. Imagine having a terrible medical condition and not knowing what it was. More than 400,000 Albertans have a rare disease. Many of them face challenges getting the right diagnosis, let alone finding […]
April 30, 2021

Research project examines male pregnancy and microbes in fish

A research project from the lab of University of Oregon evolutionary biologist Bill Cresko is setting out to explore the effects of a remarkable evolutionary innovation: male pregnancy in seahorses, pipefish and seadragons. “This is an amazingly diverse family of fish, and some species are the only vertebrates in which […]
April 30, 2021

NEI 3-D Retina Organoid Challenge (3-D ROC), Phase III

The National Eye Institute (NEI), part of the National Institutes of Health, is seeking in vitro, stem-cell-derived 3-D human retina organoids. The goal of the challenge is to generate concrete prototypes of 3-D systems that model the cellular organization and function of the human retina. NEI is seeking innovative solutions […]
April 30, 2021

Human genome editing requires difficult conversations between science and society

In October of 2020, Jennifer Doudna and Emmanuelle Charpentier were awarded the Nobel Prize in chemistry for their discovery of an adaptable, easy way to edit genomes, known as CRISPR, which has transformed the world of genetic engineering. CRISPR has been used to fight lung cancer and correct the mutation […]
April 30, 2021

New mouse model provides first platform to study late-onset Alzheimer’s disease

University of California, Irvine biologists have developed a new genetically engineered mouse model that, unlike its predecessors, is based on the most common form of Alzheimer’s disease. The advance holds promise for making new strides against the neurodegenerative disease as cases continue to soar. Their study appears in the journal, Nature […]
April 30, 2021

Anemia discovery points to more effective treatment approaches

A combination of inexpensive oral medications may be able to treat fatigue-inducing anemias caused by chronic diseases and inflammation, a new discovery from the University of Virginia School of Medicine suggests. This type of anemia is the second-most common kind, and it can be an added burden for organ-transplant recipients and […]
April 30, 2021

Innovative cancer therapy uses immune system to attack tumours

Imagine if you could re-engineer your immune system to target and attack cancer growing in your body. A new clinical trial led by a clinician-researcher at the University of Alberta is doing just that. Michael Chu, an assistant professor of oncology in the Faculty of Medicine & Dentistry, is leading a […]
April 29, 2021

Smart Cell Therapies for Solid Cancers Ready to Move Towards Clinical Trials

Immunotherapies that fight cancer have been a life-saving advancement for many patients, but the approach only works on a few types of malignancies, leaving few treatment options for most cancer patients with solid tumors. Now, in two related papers published in Science Translational Medicine, researchers at UCSF have demonstrated how to […]
April 29, 2021

Study strengthens links between red meat and heart disease

The research is presented at ESC Preventive Cardiology 2021, an online scientific congress of the European Society of Cardiology (ESC) and published in the journal Frontiers in Cardiovascular Medicine. Study author Dr Zahra Raisi-Estabragh from Queen Mary’s William Harvey Research Institute said: “Previous studies have shown links between greater red meat […]
April 29, 2021

Surgical procedure may help restore hand and arm function after stroke

Every year, more than 795,000 people in the United States have a stroke. Of these, approximately 80% lose arm function and as many as 50-60% of this population still experience problems six months later. Traditionally, stroke patients try to regain motor function through physical rehabilitation, where patients re-learn pre-stroke skills, such as eating […]
April 29, 2021

Scientists uncover secret of the hunger switch in the brain

A new study published in Science, has revealed how the master switch for hunger in the brain, the melanocortin receptor 4 (MC4), works. The research team, including scientists from the Weizmann Institute of Science, Queen Mary University of London and the Hebrew University of Jerusalem, also clarified how this switch is […]
April 29, 2021

Study: Many children with cardiomyopathy have a genetic mutation but few are screened

A national, University at Buffalo-led study on genes in pediatric cardiomyopathy demonstrates strong evidence for routine genetic screening in children with the disease. The study, published in the Journal of the American Heart Association, revealed wide variation in screening, with some centres conducting routine genetic testing and others conducting none. […]
April 29, 2021

New research shows how immune response to TB differs in babies

The immune response to tuberculosis (TB) differs in adults and newborn babies due to the way immune cells use energy to kick into gear in a bid to kill the bacteria. This fresh discovery – just published in leading journal, Frontiers in Immunology – offers hope for improving treatments for what remains […]
April 29, 2021

TARGETING TUMORS WITH NANOWORMS

Drugs and vaccines circulate through our vascular system reacting according to their chemical and structural nature. In some cases, their destination is diffuse. In other cases, like cancer treatments, the intended target is highly localized. The effectiveness of a medicine —and how much is needed and the amount of side-effects […]
April 29, 2021

Researcher uses nanomedicine to improve effectiveness and safety of chemotherapy

A University of Alberta researcher is using nanotechnology to improve the effectiveness of chemotherapy treatments for cancer patients and reduce their side effects. Afsaneh Lavasanifar is a professor in the University of Alberta’s Faculty of Pharmacy & Pharmaceutical Sciences and an adjunct professor in the Department of Chemical and Medical Engineering. Her lab develops […]
April 29, 2021

Draining brain’s debris enhances Alzheimer’s therapies in mice

Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving drainage of fluid — and debris — from […]
April 29, 2021

Stroke-recovery device using brain-computer interface receives FDA authorization

Innovative multidisciplinary research at Washington University led to development of 'breakthrough' device. A first-of-its-kind device that helps people disabled by stroke regain significant control over their arm and hand function by using their minds has received market authorization from the Food and Drug Administration (FDA). The IpsiHand Upper Extremity Rehabilitation […]
April 29, 2021

Brain changes following traumatic brain injury share similarities with Alzheimer’s disease

Brain changes in people with Alzheimer’s disease and in those with mild traumatic brain injuries have significant similarities, a new USC study shows, suggesting new ways to identify patients at high risk for Alzheimer’s. The findings appeared in GeroScience. Traumatic brain injuries, or TBIs, affect over 1.7 million Americans every […]
April 29, 2021

Brain’s waste removal system may offer path to better outcomes in Alzheimer’s therapy

Enhancing the brain’s lymphatic system when administering immunotherapies may lead to better clinical outcomes for Alzheimer’s disease patients, according to a new study in mice. Results published in Nature suggest that treatments such as the immunotherapies BAN2401 or aducanumab might be more effective when the brain’s lymphatic system can better drain […]
April 29, 2021

Research shows cytonemes distribute Wnt proteins in vertebrate tissue

Scientists have made a pivotal breakthrough in understanding the way in which cells communicate with each other. A team of international researchers, including experts from the University of Exeter’s Living Systems Institute, has identified how signalling pathways of Wnt proteins – which orchestrate and control many cell developmental processes – […]
April 29, 2021

Research gives new insight into formation of the human embryo

Pioneering research led by experts from the University of Exeter’s Living Systems Institute has provided new insight into formation of the human embryo. The team of researchers discovered an unique regenerative property of cells in the early human embryo. The first tissue to form in the embryo of mammals is […]
April 29, 2021

Cancer-linked mutation accelerates growth of abnormal stroke-causing brain blood vessels

Researchers have discovered an explanation for why cerebral cavernous malformations (CCMs)—clusters of dilated blood vessels in the brain—can suddenly grow to cause seizures or stroke. Specifically, they found that a specific, acquired mutation in a cancer-causing gene (PIK3CA) could exacerbate existing CCMs in the brain. Furthermore, repurposing an already existing […]
April 29, 2021

Scientists develop new class of cancer drug with potential to treat leukaemia

Scientists have made a promising step towards developing a new drug for treating acute myeloid leukaemia, a rare blood disorder. In a study published today in Nature, Cambridge researchers report a new approach to cancer treatment that targets enzymes which play a key role in translating DNA into proteins and which […]
April 29, 2021

New cancer algorithm flags genetic weaknesses in tumours

A new way to identify tumours that could be sensitive to particular immunotherapies has been developed using data from thousands of NHS cancer patient samples sequenced through the 100,000 Genomes Project. The MMRDetect clinical algorithm makes it possible to identify tumours that have ‘mismatch repair deficiencies’ and then improve the personalisation of cancer therapies to exploit […]
April 29, 2021

New technology could allow more cancer patients to benefit from immunotherapy

Professor Naoto Hirano of the Temerty Faculty of Medicine and collaborators have developed a new technology that rigorously and robustly identifies the immune cells that are capable of recognizing and eliminating cancer cells. The findings, published in Nature Biotechnology, pave the way for novel immunotherapies to help more patients, regardless of their genetic ancestry, […]
April 28, 2021

Epilepsy discovery reveals why some seizures prove deadly

New research from the University of Virginia School of Medicine has shed light on the No. 1 cause of epilepsy deaths, suggesting a long-sought answer for why some patients die unexpectedly following an epileptic seizure. The researchers found that a certain type of seizure is associated with sudden death in a […]
April 28, 2021

New method preserves viable fruit fly embryos in liquid nitrogen

Cryopreservation, or the long-term storage of biomaterials at ultralow temperatures, has been used across cell types and species. However, until now, the practical cryopreservation of the fruit fly (Drosophila melanogaster) — which is crucial to genetics research and critical to scientific breakthroughs benefiting human health — has not been available. […]
April 28, 2021

DNA replication: A game of precision

Stretching out the DNA in all 46 chromosomes packed into one human cell would make a string of DNA two meters long. Accurately replicating all that DNA is vital to survival; cells must control this process with tremendous precision in time and space. Origin recognition complexes (ORCs) initiate the task […]
April 28, 2021

Understanding how DNA repairs itself may lead to better cancer treatments

From cancer treatment to sunlight, radiation and toxins can severely damage DNA in both harmful and healthy cells. While the body has evolved to efficiently treat and restore damaged cells, the mechanisms that allow this natural repair remain misunderstood. In a new study, Northwestern University researchers have used cryogenic electron […]
April 28, 2021

Genetic Changes in Head and Neck Cancer, Immunotherapy Resistance Identified

A multi-institutional team of researchers has identified both the genetic abnormalities that drive pre-cancer cells into becoming an invasive type of head and neck cancer and patients who are least likely to respond to immunotherapy. “Through a series of surprises, we followed clues that focused more and more tightly on […]