Related Science News

December 17, 2020

Senescent Cells Fail to Maintain Proteostasis

Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking place than was previously the case. In many cases it isn't all that clear […]
December 17, 2020

Women face higher risk of death or heart failure following a heart attack: study

“The women were on average a decade older than men at the time of their first heart attack and they more commonly presented with the less severe type of heart attack,” said lead author Justin Ezekowitz, professor of medicine and co-director of the Canadian VIGOUR Centre. “But when they were faced with […]
December 17, 2020

FDA Enlists Georgia Tech to Establish Best Practices for RNA-sequencing

Next-generation sequencing (NGS) has emerged as an important high throughput technology in biomedical research and translation for its ability to accurately capture genetic information. But choosing proper analysis methods for identifying biomarkers from high throughput data remains a critical challenge for most users. For instance, RNA-sequencing (RNA-seq) is an NGS […]
December 17, 2020

Inhibiting protein in pancreatic tumors slows down cancer growth and increases survival rates

Georgetown University, Lawrence Livermore National Laboratory (LLNL) scientists and collaborators have identified a protein that when removed from the body may help pancreatic cancer patients live longer. Pancreatic cancer is one of the most lethal forms of the disease and has the lowest survival rate. Because the tumors are solid, many modern […]
December 15, 2020

Autophagy is a Balance, More is Usually Good, While Too Much More is Harmful

One of the more intriguing findings to emerge from study of the relationship between stress response mechanisms in cellular metabolism and the pace of degenerative aging is that evolution has not optimized for life span. Many aspects of metabolism can be adjusted in small ways – in mice, worms, flies, […]
December 15, 2020

Stanford researchers develop new tool for watching and controlling neural activity

A new molecular probe from Stanford University could help reveal how our brains think and remember. This tool, called Fast Light and Calcium-Regulated Expression or FLiCRE (pronounced “flicker”), can be sent inside any cell to perform a variety of research tasks, including tagging, recording and controlling cellular functions. “This work […]
December 15, 2020

Schizophrenia may be similar to immune disorders, scientists show

A study by clinical scientists at The University of Manchester has shown that schizophrenia may – in some part – be caused by disordered functioning of the immune system. The first-ever trial in the schizophrenia of the powerful immune suppressant drug, Methotrexate, produced what the team described as ‘promising’ effects on […]
December 15, 2020

“SCOUT” helps researchers find, quantify significant differences among organoids

Unbiased, high-throughput analysis pipeline improves utility of “minibrains” for understanding development and diseases such as Zika infection. The ability to culture cerebral organoids, or “minibrains,” using stem cells derived from people has given scientists experimentally manipulable models of human neurological development and disease, but not without confounding challenges. No two […]
December 14, 2020

New drug moves closer to becoming first treatment for Fragile X Syndrome

A new drug discovered through a research collaboration between the University at Buffalo and Tetra Therapeutics took a major step toward becoming a first-in-class treatment for Fragile X Syndrome, a leading genetic cause of autism. The drug, BPN14770, achieved positive topline results in phase 2 clinical study. The innovative treatment […]
December 14, 2020

Science Fiction Meets Neuro-Reality: Organoids to Rebuild the Brain

Computer-augmented brains, cure to blindness, and rebuilding the brain after injury all sound like science fiction. Today, these disruptive technologies aren’t just for Netflix, “Terminator,” and comic book fodder — in recent years, these advances are closer to reality than some might realize, and they have the ability to revolutionize […]
December 14, 2020

DoD-funded effort to restore vision to injured service members and people with disease

A team of researchers led by the University of Wisconsin–Madison professor David Gamm is developing a transplantable retinal patch intended to help restore vision to military personnel blinded in the line of duty and to treat individuals with degenerative eye diseases such as macular degeneration. The technology, funded by a […]
December 14, 2020

Study finds that by age 3 kids prefer nature's fractal patterns

Before their third birthdays, children already have an adult-like preference for visual fractal patterns commonly seen in nature, report University of Oregon researchers. That discovery emerged among children raised in a world of Euclidean geometry, such as in houses with rooms constructed with straight lines in a simple nonrepeating manner, […]
December 14, 2020

Higher BMI Does Not Prevent Bloodstream Infections

It’s a paradox that has puzzled epidemiologists for a long time. Why do some studies suggest that a higher body mass index (BMI) can end up “protecting” against bloodstream infections? A team of researchers from the Yale School of Public Health, in collaboration with colleagues at the Norwegian University of […]
December 14, 2020

Research findings offer hope for treatment of inflammatory skin condition

People diagnosed with an inflammatory skin condition known as granuloma annulare (GA) develop raised red lesions that emerge in ring-like patterns on the skin. For those with a chronic condition, these lesions can cover much of the body and degrade their quality of life. Until now, however, there has been […]
December 14, 2020

‘Fun size’ Cas9 nucleases hold promise for easier genome editing

Researchers from Skoltech and their colleagues from Russia and the US have described two new, compact Cas9 nucleases, the cutting components of CRISPR-Cas systems, that will potentially expand the Cas9 toolbox for genome editing. One of the two nucleases has been shown to work in human cells and thus can […]
December 13, 2020

A new evolutionary clue

Nearly two decades ago, a small-bodied “human-like” fossil, Homo floresiensis, was discovered on an island in Indonesia. Some scientists have credited the find, now nicknamed “Hobbit,” as representative of a human ancestor who developed dwarfed features after living on the island, while others suggest it represents modern human suffering from some […]
December 12, 2020

The genetics of side-effects

Henk-Jan Guchelaar knows all too well the serious problems that the side–effects of medication can cause. As a professor of clinical pharmacy at the University of Leiden in the Netherlands, he has spent the last two decades trying to get the link between medicine and our genes recognised more widely.  The stories he hears from patients […]
December 11, 2020

One more clue to brain changes in Huntington’s disease

Huntington’s disease is a fatal inherited disorder that strikes most often in middle age with mood disturbances, uncontrollable limb movements, and cognitive decline. Years before symptom onset, brain imaging shows degeneration of the striatum, a brain region important for the rapid selection of behavioural actions. As the striatal neurons degenerate, […]
December 11, 2020

Testing memory over four weeks could predict Alzheimer's disease risk

New research suggests testing people's memory over four weeks could identify who is at higher risk of developing Alzheimer's disease before it has developed. Importantly, the trial found testing people's ability to retain memories for longer time periods could predict this more accurately than classic memory tests, which test memory […]
December 11, 2020

New research identifies which T cells patrol the body

The blood is the main source of studies on the immune system, despite the fact that most diseases are combated by immune cells in the body’s tissues. A new study from Karolinska Institutet and the University of Pennsylvania has identified which immune cells patrol the human body’s tissues and circulate […]
December 11, 2020

Genetic differences important for Alzheimer's diagnosis

The two used methods for detecting amyloid pathology in Alzheimer's disease do not give unambiguous results, with the risk of incorrect or delayed care interventions. Now, researchers at Karolinska Institutet have found genetic explanations for the differences. The study is published in Molecular Psychiatry and may be important for more […]
December 11, 2020

Toxin provides clues to long-term effects of diarrhea caused by E. coli

For people in wealthy countries, diarrhea is usually nothing more than an uncomfortable inconvenience for a few days. But for a poor child in a developing country, repeated bouts of diarrhea can lead to serious health consequences such as malnutrition, stunted growth and cognitive deficits. Researchers at Washington University School […]
December 11, 2020

The Long Reach of Pandemics

Epidemics and pandemics are not equal-opportunity killers. Seen through the archaeological record, incomplete as it may be, these waves of death victimized the marginalized and most vulnerable populations wherever they struck. In the U.S., the COVID-19 pandemic appears to be no different, striking Indigenous, Black and Latinx communities at far […]
December 11, 2020

Using CRISPR, new technique makes it easy to map genetic networks

CRISPR-Cas9 makes it easy to knock out or tweak a single gene to determine its effect on an organism or cell, or even another gene. But what if you could perform several thousand experiments at once, using CRISPR to tweak every gene in the genome individually and quickly see the […]
December 10, 2020

News Releases News Topics Media Advisories University Statements Study: Memory deficits resulting from epigenetic changes in Alzheimer’s disease can be reversed

Memory loss associated with Alzheimer’s disease (AD) may be able to be restored by inhibiting certain enzymes involved in abnormal gene transcription, according to a preclinical study by researchers at the University at Buffalo. The findings could pave the way toward new treatments for Alzheimer’s disease. The paper will be […]