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Progeria is a rare genetic condition in which cells throughout the body become misshapen, dysfunctional, and damaged due to the accumulation of a broken form of the structural protein lamin A, called progerin. This produces outcomes that in some ways resemble accelerated aging. Aging is, after all, the accumulation of […]

Most cancer treatments produce a lot of senescent cells in the course of killing cancerous cells. This is thought to be the primary reason as to why cancer survivors have a reduced life expectancy and greater burden of age-related disease. Senescent cells secrete disruptive, inflammatory signals that harm tissue function […]

It is indisputably the case that regular exercise and maintenance of physical fitness into later life lowers the incidence and slows the progression of neurodegenerative disease. One can write any number of reviews akin to today's open access paper, walking through the evidence for cellular pathways involved in neurodegeneration to […]

Biochemistry is complex, and particularly so in the brain. The amyloid cascade hypothesis of Alzheimer's disease essentially states that slow aggregation of amyloid-β over years causes the onset of later and much more severe stages of Alzheimer's disease, meaning the chronic inflammation in brain tissue and tau aggregation that kills […]

Senescent cells accumulate with age, but are never more than a tiny fraction of somatic cells in most tissues, even in very late life. Senescent cells nonetheless cause considerable harm via the signals that they produce, the senescence-associated secretory phenotype (SASP). These signals provoke chronic inflammation, harmful remodeling of tissue, […]

Skin cancer is a treatable condition and immunotherapies can be very effective. But even our novel medicine can be improved. A team of researchers led by the University of Birmingham found that skin cancer patients may have better prognosis if their immune system is empowered. T cells just need to […]

Muscle mass and strength declines with age, leading to sarcopenia and contributing to frailty. Many distinct mechanisms are thought to be involved, from stem cell inactivity to chronic inflammation. Most of these mechanisms are favorably impacted by the sweeping metabolic changes induced by the practice of calorie restriction. The study […]

DNA defects are linked to cancer and may be primary reasons for aging. However, scientists argue that protein errors are responsible for some negative health changes as well. Researchers at UCL conducted experiments with simple model organisms and found that correcting protein production errors leads to improvements in both health […]

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy. Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to an immunotherapy treatment for cancer. The approach, proven in mice experiments, was […]