Related Science News – Page 59 – Innovita Research

Related Science News

April 20, 2020

Finding Leukemia’s Weakness Using Genome-Wide CRISPR Technology

A team of researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia, a type of cancer that remains difficult to treat and is marked by frequent relapse. “We used CRISPR technology to carry […]
April 20, 2020

A subset of suppressive lymphocytes switches to promote autoimmune disease when activated by glycolipids in the face of inflammation

Researchers from Karolinska Institutet in collaboration with a lab in San Antonio USA, have uncovered how a specific population of lymphocytes promotes autoimmune disease by giving up their regulatory role in the immune system. The newly discovered mechanism is published in PNAS from research led by Dr. Saikiran Sedimbi and […]
April 20, 2020

Electronic health records used in study of drug-effectiveness to reduce risk of Alzheimer’s disease

Researchers have harnessed the power of electronic health records to gain insight in the potential of inflammation-controlling medications to reduce a patient’s Alzheimer’s disease risk. Rong Xu, professor of Biomedical Informatics and director of the Center for Artificial Intelligence in Drug Discovery at Case Western Reserve University; Mark Gurney, chairman […]
April 20, 2020

The optimal immune repertoire for bacteria

Before CRISPR became a household name as a tool for gene editing, researchers had been studying this unique family of DNA sequences and its role in the bacterial immune response to viruses. The region of the bacterial genome known as the CRISPR cassette contains pieces of viral genomes, a genomic […]
April 20, 2020

CRISPR-Based ‘Discovery Engine’ for New Cell Therapies to Advance Cancer Treatments

Despite centuries-long efforts to develop cures for cancer, various forms of the disease will kill about 630,000 people in the U.S. in 2020. But hopes are rising for cell therapies – sometimes called “living medicines” – that can boost and adapt the natural cancer-fighting potential of the immune system in ways […]
April 19, 2020

A Phenoptosis Perspective on the Evolution of Exceptional Human Longevity

The conclusion to today's open access paper opens with the following declaration: “There is still no agreement among gerontologists as to the main aging-related issue: whether it is an accidental accumulation of damage in the organism or a result of the operation of a specially evolved program.” This is true in the […]
April 19, 2020

Using the CellAge Database to Find Genes Associated with Inhibition of Cellular Senescence

The CellAge database was announced last year, a repository of information on genes linked to cellular senescence. Cells become senescent in response to a variety of stresses, or upon reaching the Hayflick limit. A senescent cell ceases replication and secretes inflammatory and pro-growth signals. The process serves a useful function when such cells are present for […]
April 19, 2020

DNA Damage During Cell Replication is Probably Not Important in Mammalian Aging

The size of the contribution of stochastic nuclear DNA damage to aging is debated. It causes cancer, when rare combinations of cancerous mutations occur and suppression of those early cancerous cells fails, but can it give rise to a meaningful degree of tissue dysfunction otherwise? The present consensus is that most such […]
April 16, 2020

When Damaged, the Adult Brain Repairs Itself by Going Back to the Beginning

When adult brain cells are injured, they revert to an embryonic state, according to new findings published in the journal Nature by researchers at University of California San Diego School of Medicine, with colleagues elsewhere. The scientists report that in their newly adopted immature state, the cells become capable of re-growing […]
April 16, 2020

Advanced, high-res MRI scans reveal link between cognitive abilities and ‘tree ring’ layers in the brain

Object recognition and facial recognition may seem like similar abilities, but new research finds that these behaviors are on the opposite ends of the spectrum when it comes to physical signatures in the brain. According to a new study, published by a team of scientists at Vanderbilt, both recognition abilities […]
April 16, 2020

Researchers restore sight in mice by turning skin cells into light-sensing eye cells

Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision. The lab-made rods enabled blind mice to detect light after the cells were transplanted into the animals’ eyes. The work, funded by the National Eye Institute (NEI), published in Nature. The NEI is […]
April 16, 2020

Landmark study of adolescent brain development renews for additional seven years

With nearly $290M of new funding for seven years to research institutions around the country, the National Institutes of Health renewed its commitment to the Adolescent Brain Cognitive Development (ABCD) Study(link is external), the largest long-term study of brain development and child health ever conducted in the United States. Launched in […]
April 16, 2020

New cancer drug shrinks tumors, reduces side effects, in animal studies

A class of experimental cancer drugs called BET inhibitors have shown promise for treating cancers of the blood but can induce toxic side effects. Now Yale researchers have found a new inhibitor that in animal studies demonstrates greater potency against a wider variety of cancers, as well as against solid […]
April 15, 2020

3D imaging of blood vessels could shed new light on cardiovascular disease

Cardiovascular disease is often the result of blood vessels becoming clogged by plaques—buildups of fat, calcium, and other substances that may restrict blood flow. Not every plaque is created equal, however; some are more likely to induce a heart attack or stroke than others. Now a new three-dimensional imaging technique […]
April 15, 2020

Diet may help preserve cognitive function

According to a recent analysis of data from two major eye disease studies, adherence to the Mediterranean diet – high in vegetables, whole grains, fish, and olive oil – correlates with higher cognitive function. Dietary factors also seem to play a role in slowing cognitive decline. Researchers at the National […]
April 15, 2020

Study tracks genomics of lung tumor behavior

A study by Vanderbilt researchers has identified genomic alterations in early-stage adenocarcinomas of the lung that may indicate whether the lesions develop into aggressive tumors. The study published in the American Journal of Respiratory and Critical Care Medicine is the largest analysis of in situ and early adenocarcinomas lesions using targeted sequencing. […]
April 15, 2020

Large-scale analysis links glucose metabolism proteins in the brain to Alzheimer’s disease biology

In the largest study to date of proteins related to Alzheimer’s disease, a team of researchers has identified disease-specific proteins and biological processes that could be developed into both new treatment targets and fluid biomarkers. The findings suggest that sets of proteins that regulate glucose metabolism, together with proteins related to […]
April 15, 2020

Tailoring treatment for triple-negative breast cancer

Immunotherapies have revolutionized treatment for people with a variety of cancers. But when given to those with triple-negative breast cancer (TNBC), a particularly aggressive form of the disease, less than 20% respond. “A big question in the field has been, Why are the rest not responding?” says Rumela Chakrabarti, an assistant […]
April 14, 2020

Therapies show knockout potential for rare, deadly liver cancer

A new study identifies some of the most critical genes that may drive a rare but deadly liver cancer, providing a road map for developing drugs that target those genes. The cancer, fibrolamellar carcinoma, accounts for 1-5% of all liver cancers, and disproportionately affects children and young adults. By the […]
April 14, 2020

New research gives insights into how a group of novel organelle-based disorders affects cells

A pioneering study has shed new light on how a group of novel organelle-based disorders affect cells. The study led by Professor Michael Schrader from the University of Exeter, and featuring an international, multi-disciplinary team of scientists, has explored on peroxisome alterations and their contribution to the disease. Organelles are the functional units […]
April 14, 2020

New study shows how oxygen transfer is altered in diseased lung tissue

A multidisciplinary team of researchers at the University of Illinois at Urbana-Champaign has developed tiny sensors that measure oxygen transport in bovine lung tissue. The study – which establishes a new framework for observing the elusive connection between lung membranes, oxygen flow and related disease – was published in the […]
April 14, 2020

Switching on a key cancer gene could provide first curative treatment for heart disease

Researchers trying to turn off a gene that allows cancers to spread have made a surprising U-turn. By making the gene overactive and functional in the hearts of mice, they have triggered heart cell regeneration. Since adult hearts cannot usually repair themselves once damaged, harnessing the power of this gene […]
April 14, 2020

Researchers Uncover Importance of Aligning Biological Clock with Day-Night Cycles

Timing is everything. A fresh example supporting the old saying has been found in connection with the systems regulated by biological clocks. Research on circadian rhythms, our internal 24-hour patterns that affect sleep-wake and metabolic cycles, has shown that timing is key for human health. When our activities and internal […]
April 14, 2020

Technique tracks gene expression changes as cells change

A new technique makes it possible to track changes in gene activity across a cell’s entire genome over time in more detail than has been possible before, researchers in Seattle report. “We hope this method will improve our understanding of normal cell physiology and as well as of cell dynamics […]
April 14, 2020

Yale test of immunotherapy drug for advanced lung cancer shows promise

Lung cancer spreads to the brain in about one-quarter of patients with an advanced form of the disease. To date, radiation has been the only treatment option, but it comes with toxic side effects. Researchers at Yale Cancer Center (YCC) have found that the use of the checkpoint inhibitor pembrolizumab in […]
April 9, 2020

Autoimmunity may be rising in the United States

Autoimmunity, a condition in which the body’s immune system reacts with components of its own cells, appears to be increasing in the United States, according to scientists at the National Institutes of Health and their collaborators. In a study published in Arthritis and Rheumatology, the researchers found that the prevalence […]
April 9, 2020

Tiny Nanoparticles Offer Large Potential for Brain Cancer Treatment

For patients with malignant brain tumors, the prognosis remains dismal. With the most aggressive treatments available, patients are usually only expected to live about 14 months after diagnosis. This is because, chemotherapy, the most common form of treatment for cancer, is uniquely challenging for brain tumor patients. The delicate organ […]
April 8, 2020

Loss of Autophagy in Hematopoietic Cells Contributes to Osteoporosis

This open access paper is an example of one of the less well known connections between processes of aging. Loss of efficiency of the cellular maintenance processes of autophagy is a characteristic of cells in old tissues. Here, researchers note that this dysfunction in the hematopoietic cells responsible for creating blood and immune […]
April 8, 2020

Engineered Stem Cells Survive Longer and Improve Outcomes in a Heart Patch

In most cell therapies, the transplanted cells do not survive for long, or in large numbers. They produce beneficial effects, such as reduced inflammation or enhanced regeneration, via signaling that changes the behavior of native cell populations. Considerable effort is going into finding ways to make cells used in therapy survive for […]
April 8, 2020

PARP Inhibitor Drugs Can be “Tuned” for Better Killing of Tumor Cells

A prospective “PARP inhibitor” drug that has struggled to show effectiveness in clinical trials against cancers can be structurally modified to greatly increase its power to kill tumor cells, researchers from Penn Medicine report in Science. The team also showed that PARP inhibitor compounds can be “tuned” in the opposite […]