Related Science News – Page 33 – Innovita Research

Related Science News

January 31, 2021

Our gut-brain connection

In many ways, our brain and our digestive tract are deeply connected. Feeling nervous may lead to physical pain in the stomach, while hunger signals from the gut make us feel irritable. Recent studies have even suggested that the bacteria living in our gut can influence some neurological diseases. Modelling […]
January 31, 2021

A high-resolution glimpse of gene expression in cells

Using a novel technique for expanding tissue, MIT and Harvard Medical School researchers have devised a way to label individual molecules of messenger RNA within a tissue sample and then sequence the RNA. This approach offers a unique snapshot of which genes are being expressed in different parts of a […]
January 31, 2021

How a Cancer Drug Carrier's Structure Can Help Selectively Target Cancer Cells

Porphyrins are interesting drug delivery vehicles that can specifically accumulate in cancer cells. However, how the structure of the drug-conjugated porphyrin affects its ability to penetrate and accumulate within cancer cells is not well understood. Researchers from Tokyo University of Science now investigate the correlation between the structure and tumor […]
January 30, 2021

AGEs Contribute to Disc Degeneration via Interaction with RAGE

Advanced glycation endproducts (AGEs) are a form of metabolic waste, sugary compounds that can interact harmfully with structures and cells in the body. A few forms of persistent AGE can form lasting cross-links in the extracellular matrix that change the structural properties of tissues, contributing to the loss of elasticity […]
January 30, 2021

How a Little-Known Glycoprotein Blocks a Cancer Cell’s Immune Response

It was an unexpected discovery that started with an analysis of more than 1,000 genes. The question: why game-changing cancer immunotherapy treatments work for only a fraction of patients. The analysis shone a light on one that popped up repeatedly in patients and mouse models that did not respond to […]
January 30, 2021

‘Smart’ cartilage cells programmed to release drugs when stressed

Working to develop new treatments for osteoarthritis, researchers at Washington University School of Medicine in St. Louis have genetically engineered cartilage to deliver an anti-inflammatory drug in response to activity similar to the bending of a knee or other motions that put stress on joints. Among the early symptoms of […]
January 30, 2021

Risk-taking behavior has a signature in the brain, big data shows

What makes one person drive above the speed limit while another navigates steadily in the right lane? What motivates someone to leave a job with a steady paycheck to launch their own business while the other sticks to one employer for an entire career? “People have different tendencies to engage […]
January 30, 2021

Losing weight before knee surgery may not be beneficial for people with arthritis: study

A new University of Alberta study shows that losing weight before knee replacement surgery doesn’t lead to better outcomes for patients. In a systematic review published in Joint Bone Spine, researchers in the Faculty of Rehabilitation Medicine found that weight loss before surgery may not be beneficial for people with advanced knee osteoarthritis. Medical practitioners have long advised […]
January 30, 2021

‘Cellular chatter’: Researchers aim to decode communications within a tumor

Inside a tumor, chatter abounds. Multiple cell types are constantly communicating with each other, exchanging various types of information. Some are working together against the tumor, while others help the tumor grow. Researchers have a good handle on who the main players are, but it can be difficult to tell […]
January 30, 2021

UCLA Researchers Jump-Start Two Patients’ Brains, Leading to Recovery after Coma

Martin Monti, a Professor of Psychology and Neurosurgery at UCLA, and colleagues have recently published a paper in the journal Brain Stimulation, describing their success in jump-starting the brains of two patients in a long-term “minimally conscious state”. While Monti had already performed a similar procedure on a 25-year-old man […]
January 30, 2021

QFold: Quantum Walks and Deep Learning to Solve Protein Folding

The problem of protein folding is one of the most important and hard tasks in computational biochemistry. Recently, deep learning models, such as AlphaFold, were shown to be more effective in this task than classical techniques. The likely advance of quantum computing could help to improve current algorithms further. A […]
January 29, 2021

New combination of immunotherapies shows great promise for treating lung cancer

McMaster researchers have established in lab settings that a novel combination of two forms of immunotherapy can be highly effective for treating lung cancer, which causes more deaths than any other form of cancer. The new treatment, yet to be tested on patients, uses one form of therapy to kill […]
January 29, 2021

Oxytocin has potential as a therapy for autism, research finds

A team of international researchers who study how gene mutations associated with autism interfere with social behaviour have found injections of the hormone oxytocin can normalize brain activity. The findings, which were presented recently at the 2021 Society for Neuroscience Global Connectome, point to the potential of oxytocin—known to influence behaviours […]
January 29, 2021

Immune cells are behind the depression experienced in inflammation

Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation. The findings from a new study on mice suggest that microglial cells contribute to the negative mood experienced during several neurological diseases. David Engblom’s […]
January 29, 2021

Advocating the Use of Low Dose Ionizing Radiation as a Hormetic Treatment

Many forms of mild cellular stress produce benefits to health because they trigger the more efficient operation of cellular maintenance processes such as autophagy. That in turn causes better cell and tissue function, and thus improved health. This stress response and benefit is known as hormesis, and has been robustly […]
January 29, 2021

Researchers use patients’ cells to test gene therapy for rare eye disease

Scientists at the National Eye Institute (NEI) have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood. A form of Leber congenital amaurosis, the disease is caused by autosomal-dominant mutations in the CRX gene, which are challenging to treat with gene therapy.  The scientists […]
January 29, 2021

Nixing bone cancer fuel supply offers new treatment approach, mouse study suggests

An innovative approach to treating bone tumors — starving cancer cells of the energy they need to grow — could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. […]
January 29, 2021

Researchers Identify Nanoparticles that Could Be Used in Therapeutic mRNA Delivery before Birth

Researchers at Children’s Hospital of Philadelphia and the School of Engineering and Applied Science at the University of Pennsylvania have identified ionizable lipid nanoparticles that could be used to deliver mRNA as part of fetal therapy. The proof-of-concept study, published in Science Advances, engineered and screened a number of lipid nanoparticle […]
January 29, 2021

How does the immune system keep tabs on the brain?

Alzheimer’s disease, multiple sclerosis, autism, schizophrenia and many other neurological and psychiatric conditions have been linked to inflammation in the brain. There’s growing evidence that immune cells and molecules play a key role in normal brain development and function as well. But at the core of the burgeoning field of […]
January 29, 2021

Parkinson’s disease risk and severity is tied to the activity of a channel in cells’ ‘recycling centers’

Many genetic mutations have been found to be associated with a person’s risk of developing Parkinson’s disease. Yet for most of these variants, the mechanism through which they act remains unclear. Now a new study in Nature led by a team from the University of Pennsylvania has revealed how two different variations—one […]
January 29, 2021

New TAU study reveals “Achilles’ heel” of cancer cells

What makes cancer cells different from ordinary cells in our bodies? Can these differences be used to strike at them and paralyze their activity? Cancer researchers have been debating this question since the mid-19th century. A new study from Tel Aviv University (TAU) shows, for the first time, how an abnormal […]
January 29, 2021

First ever ‘pioneer’ factor found in plants enables cells to change their fate

Cells don’t express all the genes they contain all the time. The portion of our genome that encodes eye colour, for example, doesn’t need to be turned on in liver cells. In plants, genes encoding the structure of a flower can be turned off in cells that will form a […]
January 29, 2021

Study: Detecting ADHD with near perfect accuracy

A new study led by a University at Buffalo researcher has identified how specific communication among different brain regions, known as brain connectivity, can serve as a biomarker for attention deficit hyperactivity disorder (ADHD). The research relied on a deep architecture using machine-learning classifiers to identify with 99% accuracy those […]
January 29, 2021

Alcohol Causes Immediate Effects Linked to Heart Malady

A daily alcoholic drink for women or two for men might be good for heart health, compared to drinking more or not drinking at all. But while there is some evidence that drinking in moderation might prevent heart attacks, now a randomized, double-blinded clinical study of 100 heart patients has […]
January 29, 2021

Abnormal hyperactivation in the brain may be an early sign of Alzheimer’s

Abnormally hyperactive areas in the brain may help better predict the onset of Alzheimer’s disease, according to findings of a research team led by Université de Montreal researcher Sylvie Belleville, Scientific Director of the Institut Universitaire de gériatrie de Montréal research centre and professor in the Department of Psychology at […]
January 29, 2021

Genetic analysis of symptoms yields new insights into PTSD

Attempts to identify the genetic causes of neuropsychiatric diseases such as post-traumatic stress disorder (PTSD) through large-scale genome-wide analyses have yielded thousands of potential links. The challenge is further complicated by the wide range of symptoms exhibited by those who have PTSD. For instance, does extreme arousal, anger, or irritation […]
January 28, 2021

When — Not What — Obese Mice Ate Reduced Breast Cancer Risk

Restricting eating to an eight-hour window, when activity is highest, decreased the risk of development, growth and metastasis of breast cancer in mouse models, report researchers at University of California San Diego School of Medicine, Moores Cancer Center and Veterans Affairs San Diego Healthcare System (VASDSH). The findings, published in […]
January 28, 2021

Two Anti-viral Enzymes Transform Pre-Leukemia Stem Cells into Leukemia

Cancers, such as leukemia and multiple myeloma. The self-renewing nature of cancer stem cells makes them particularly hard to eradicate, and they’re often the reason a blood cancer reoccurs. Researchers at UC San Diego Health and University of California San Diego School of Medicine are working to understand what pushes […]
January 28, 2021

Keeping sperm cells on track

One essential component of each eukaryotic cell is the cytoskeleton. Microtubules, tiny tubes consisting of a protein called tubulin, are part of this skeleton of cells. Cilia and flagella, which are antenna-like structures that protrude from most of the cells in our body, contain many microtubules. An example of flagell […]
January 28, 2021

The Enormous Clinical Potential of Senotherapeutics for the Treatment of Chronic Kidney Disease

Today's open access review paper is a high level look at what the newfound realization of the importance of senescent cells to aging and age-related disease means for the treatment of chronic kidney disease. At present there are few good options for treatment, and those therapies that are widely used […]