Related Science News – Page 15 – Innovita Research

Related Science News

August 16, 2019

Characterizing tau aggregates in neurodegenerative diseases

The microtubule-binding protein tau in neurons of the central nervous system can misfold into filamentous aggregates under certain conditions. These filaments are found in many neurodegenerative diseases such as Alzheimer’s disease, chronic traumatic encephalopathy (CTE), and progressive supranuclear palsy. Understanding the molecular structure and dynamics of tau fibrils is important […]
August 16, 2019

‘Trojan horse’ anticancer drug disguises itself as fat

A stealthy new drug-delivery system disguises chemotherapeutics as fat in order to outsmart, penetrate and destroy tumors. Thinking the drugs are tasty fats, tumors invite the drug inside. Once there, the targeted drug activates, immediately suppressing tumor growth. The drug also is lower in toxicity than current chemotherapy drugs, leading […]
August 16, 2019

Genes linked to Alzheimer’s risk, resilience ID’d

An international team of researchers led by scientists at Washington University School of Medicine in St. Louis has identified a pair of genes that influence risk for both late-onset and early-onset Alzheimer’s disease. Most genes implicated thus far in Alzheimer’s affect neurons that transmit messages, allowing different regions of the […]
August 16, 2019

Balance of “Stop” and “Go” Signaling Could Be Key to Cancer Immunotherapy Response

A crucial signaling pathway that can tell the immune system to fight off cancer can also be co-opted by cancer cells to put the brakes on the immune system, according to a new study from researchers in the Abramson Cancer Center at the University of Pennsylvania. Researchers say this increased understanding […]
August 16, 2019

Air pollution can accelerate lung disease as much as a pack a day of cigarettes

Air pollution — especially ozone air pollution which is increasing with climate change — accelerates the progression of emphysema of the lung, according to a new study led by the University of Washington, Columbia University and the University at Buffalo. While previous studies have shown a clear connection of air pollutants with […]
August 16, 2019

Mechanism of electrical signaling in cells revealed

Researchers have now obtained the long-sought after, resting-state structure of a voltage-gated sodium channel.  These types of channels in living cells form a voltage-regulated pore that allows rapid passage of positively charged sodium atoms across the cell membrane. This generates a tiny electrical signal. Electrical signals in nerve and muscle […]
August 15, 2019

Tissue model reveals role of blood-brain barrier in Alzheimer’s

Beta-amyloid plaques, the protein aggregates that form in the brains of Alzheimer’s patients, disrupt many brain functions and can kill neurons. They can also damage the blood-brain barrier — the normally tight border that prevents harmful molecules in the bloodstream from entering the brain. MIT engineers have now developed a […]
August 14, 2019

Intensive blood pressure control may slow age-related brain damage

In a nationwide study, researchers used magnetic resonance imaging (MRI) to scan the brains of hundreds of participants in the National Institutes of Health’s Systolic Blood Pressure Intervention Trial (SPRINT) and found that intensively controlling a person’s blood pressure was more effective at slowing the accumulation of white matter lesions […]
August 14, 2019

Bone strength could be linked to when you reached puberty

Published in JAMA Network Openresearchers looked at six repeated bone scans from 6,389 children in Bristol’s Children of the 90s study between the ages of ten and 25 to assess if the timing of puberty had any influence on bone density throughout adolescence and into early adulthood. They found that […]
August 14, 2019

Researchers investigate how the brain changes with different learning experiences

A new collaboration with an independent school in Menlo Park, Calif., is helping Stanford researchers better understand how different learning experiences drive changes in the brain. The Brainwave Learning Center at Synapse School brings together researchers, teachers and students to gain new insights into how young learners' brains transform as they acquire […]
August 13, 2019

Raised Risk

Scientists studying a highly cancer-prone family have identified a rare, inherited gene mutation that dramatically raises the lifetime risk of pancreatic and other cancers. The discovery of the previously unknown mutation, reported in Nature Genetics by Harvard Medical School investigators at Dana-Farber/Brigham and Women’s Cancer Center, could lead to routine testing of individuals […]
August 13, 2019

Smoldering spots in the brain may signal severe MS

Aided by a high-powered brain scanner and a 3D printer, NIH researchers peered inside the brains of hundreds of multiple sclerosis patients and found that dark rimmed spots representing ongoing, “smoldering” inflammation, called chronic active lesions, may be a hallmark of more aggressive and disabling forms of the disease. “We […]
August 13, 2019

Alzheimer’s Disease Destroys Neurons that Keep Us Awake

Researchers and caregivers have noted that excessive daytime napping can develop long before the memory problems associated with Alzheimer’s disease begin to unfold. Prior studies have considered this excessive daytime napping to be compensation for poor nighttime sleep caused by Alzheimer’s-related disruptions in sleep-promoting brain regions, while others have argued that the […]
August 13, 2019

Bacteria made to mimic cells, form communities

Rice University scientists have found a way to engineer a new kind of cell differentiation in bacteria, inspired by a naturally occurring process in stem cells. They have created a genetic circuit able to produce genetically distinguished cells of Escherichia coli as the bacterium divides. By controlling this process, it is possible […]
August 13, 2019

An alternate theory for what causes Alzheimer's disease

Alzheimer’s disease, the most common cause of dementia among the elderly, is characterized by plaques and tangles in the brain, with most efforts at finding a cure focused on these abnormal structures. But a University of California, Riverside, research team has identified alternate chemistry that could account for the various […]
August 13, 2019

Depression and Alzheimer’s

Increasingly, Alzheimer’s disease research has focused on the preclinical stage, when people have biological evidence of Alzheimer’s but either no symptoms or minimal symptoms—the time when interventions might have the potential to prevent future decline of older adults. Harvard Medical School researchers at Massachusetts General Hospital have shed new light on […]
August 12, 2019

Higher vitamin A intake linked to lower skin cancer risk

People whose diets included high levels of vitamin A had a 17 percent reduction in risk for getting the second-most-common type of skin cancer, as compared to those who ate modest amounts of foods and supplements rich in vitamin A. That’s according to researchers from Brown University, who unearthed that […]
August 12, 2019

Adding MS Drug to Targeted Cancer Therapy May Improve Glioblastoma Outcomes

Glioblastoma is an aggressive form of brain cancer that infiltrates surrounding brain tissue, making it extremely difficult to treat with surgery. Even when chemotherapy and radiation successfully destroy the bulk of a patient’s glioblastoma cells, they may not affect the cancer stem cells. This small population of tumor cells have […]
August 12, 2019

Scientists find potential 'magic bullet' for treating tumours

Researchers have found a therapy to reduce the size of tumours where previous drugs have failed. Tumours develop from abnormal cells in the body that continue to grow forming lumps. These lumps can be benign, meaning they’re not harmful, or they can become malignant which leads to cancer. Malignant tumours, […]
August 12, 2019

Artificial intelligence could yield more accurate breast cancer diagnoses

Researchers at University of Washington and University of California, Los Angeles, have developed an artificial intelligence system that could help pathologists read biopsies more accurately, and lead to better detection and diagnosis of breast cancer. Doctors examine images of breast tissue biopsies to diagnose breast cancer. But the differences between […]
August 12, 2019

Yale scientists zero in on atomic driver of tumor formation

Growing evidence suggests that certain types of bacteria are capable of causing colorectal cancers, indicating that a sub-set of these cancers could be the result of infectious disease. But understanding how bacteria interact in the human gut – our microbiome – has been challenging because of the complex microbial mixture […]
August 12, 2019

Predicting the risk of cancer with computational electrodynamics

Researchers from Northwestern University are using Argonne supercomputers to advance the development of an optical microscopy technique that can predict and quantify cancer risks at extremely early stages. The basic principle driving Allen Taflove’s computational electrodynamics research — which bears the potential to transform how we diagnose, and possibly treat, […]
August 9, 2019

Controlling the Shape-Shifting Skeletons of Cells

You know you have a skeleton, but did you know that your cells have skeletons, too? Cellular skeletons, or cytoskeletons, are shapeshifting networks of tiny protein filaments, enabling cells to propel themselves, carry cargo, and divide. Now, an interdisciplinary team of Caltech researchers has designed a way to study and […]
August 9, 2019

Electromagnetic fields may hinder spread of breast cancer cells

Electromagnetic fields might help prevent some breast cancers from spreading to other parts of the body, new research has found. The study showed that low intensity electromagnetic fields hindered the mobility of specific breast cancer cells by preventing the formation of long, thin extensions at the edge of a migrating […]
August 8, 2019

NIH researchers uncover role of repetitive DNA and protein sequences in tumor evolution

A team of researchers from the National Library of Medicine (NLM), part of the National Institutes of Health, and collaborating academic research institutions developed a method to measure a type of gene mutation involved in the evolution of cancer. This type of mutation, called “repeat instability,” may be useful in […]
August 8, 2019

The brain’s amyloid buildup is not a powerful indicator of Alzheimer’s disease

While the presence of beta-amyloid plaques in the brain may be a hallmark of Alzheimer’s disease, giving patients an amyloid PET scan is not an effective method for measuring their cognitive function, according to a new study from researchers in the Perelman School of Medicine and Thomas Jefferson University. The […]
August 8, 2019

Researchers reverse engineer the ‘fireworks of life’

Imagine standing in a lumberyard and being asked to build a house — without blueprints or instructions of any kind. The materials are all in front of you, but that doesn’t mean you have the first idea how to get from point A to point B. That was the situation […]
August 8, 2019

Probing the Origin of Alzheimer's… with Transistors

Novel high-sensitivity detector could aid in early diagnosis. A prime suspect in the onset of Alzheimer’s and Parkinson’s diseases is a normally benign enzyme that is essential to proper development of the nervous system. Under certain conditions, however, its chemical structure changes and it goes rogue, contributing to the neural […]
August 7, 2019

Beyond DNA

Pretty much all of your cells have the same DNA code, yet they come in an astonishing number of forms. Some cells contract so the heart can beat or your muscles flex. Others have jobs in the immune system, tuned to recognize different threats. Cells can change their behavior, altering […]
August 7, 2019

Blood test is highly accurate at identifying Alzheimer’s before symptoms arise

Up to two decades before people develop the characteristic memory loss and confusion of Alzheimer’s disease, damaging clumps of protein start to build up in their brains. Now, a blood test to detect such early brain changes has moved one step closer to clinical use. Researchers from Washington University School […]