Related Science News – Page 75 – Innovita Research

Related Science News

November 27, 2021

IKK/NF-κB Activation as a Target for Senotherapeutics

The accumulation of senescent cells in later life is a contributing cause of aging. While these errant cells never amount to more than a tiny fraction of all cells in a tissue, their inflammatory signaling is harmful. Researchers here describe an approach to diminish that inflammatory signaling, thereby reducing the […]
November 26, 2021

Results From a Small, Informal Trial of Telomerase and Klotho Gene Therapy for Alzheimer's Disease

Bioviva was at one point developing telomerase gene therapies, work that has transitioned into the medical tourism industry via Integrated Health Systems rather than proceeding towards regulatory approval. The institutional communities of science and funding strongly disapproved of the self-experiment undertaken by the Bioviva founder, and the way that self-experiment […]
November 25, 2021

A Senolytic Treatment Improves Visual Function in a Small Trial for Macular Degeneration

UNITY Biotechnology recently reported positive results for their senolytic drug candidate UBX1325, probably derived from navitoclax. Senolytic therapies selectively destroy senescent cells in aged tissues, reducing their inflammatory signaling and contribution to tissue dysfunction. In this case, macular degeneration patients showed improved visual function after treatment, though one should wait […]
November 24, 2021

Researchers Develop New Algorithm for Linking Genes and Specific Diseases

Researchers from ITMO’s Laboratory of Genomic Diversity and the World-Class Research Centre for Personalized Medicine have developed GPrior (gene prioritizer), an algorithm that uses data from a genome-wide association study (GWAS) to identify the genes responsible for a particular disease. For this study, the group used the data on schizophrenia, […]
November 24, 2021

Looking Deeper into Age-Related Changes in the Skin Microbiome

For reasons yet to be determined, the composition of the skin microbiome changes with age. It is also unclear as to whether these changes contribute to skin aging in any meaningful way, or are instead a consequence of skin aging. Researchers here perform a proof of concept study to identify […]
November 24, 2021

Researchers discover an unexpected regulator of heart repair

A study using mice by scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA reveals that cardiac muscle cells play a pivotal role in determining how the heart heals following a heart attack. The findings challenge a longstanding paradigm about heart repair […]
November 23, 2021

Some Cell Therapies Reduce Inflammation Precisely Because the Transplanted Cells Die

First generation stem cell therapies have been demonstrated to reduce chronic inflammation, but are unreliable when it comes to producing other benefits. Since very few transplanted cells survive, it was thought that benefits are produced via signaling that changes the behavior of native cells. This has led to work on […]
November 22, 2021

Exposure to Harmless Coronaviruses Boosts SARS-CoV-2 Immunity

Infections with the novel coronavirus and vaccination lead to strong antibody responses against SARS-CoV-2. Immune responses to other human coronaviruses, which mostly only cause harmless colds, also provide some protection against SARS-CoV-2. This cross-reactive immune response is an important piece of the puzzle of how to achieve comprehensive coronavirus immunity, […]
November 22, 2021

The Age-Related Decline of Energy Metabolism in Myeloid Cells as an Important Cause of Neurodegeneration

Today's open access editorial discusses one quite specific consequence of the age-related disruption of energy metabolism in cells. Mitochondria, the power plants of the cell, falter with age throughout the body, for complex reasons still under exploration. The proximate causes involve too little production of molecular machinery needed for the […]