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Cambridge scientists have grown beating heart cells in the lab and shown how they are vulnerable to SARS-CoV-2 infection. In a study published in Communications Biology, they used this system to show that an experimental peptide drug called DX600 can prevent the virus entering the heart cells. The heart is one […]

Hematopoietic stem cells — the precursors to blood cells — have been notoriously difficult to grow in a dish, a critical tool in basic research. Scientists at University of California San Diego School of Medicine have identified the underlying issue and developed a method to keep cultured cells healthy. These […]

IGF-1 is one of the better studied areas of metabolism relevant to determining the pace of aging in a species, involved in the regulation of tradeoffs between growth and sustained function. In the context of the evolution of aging, a mechanism exhibiting antagonistic pleiotropy is beneficial in youth but harmful […]

It is becoming clear that transthyretin amyloid accumulation makes a meaningful contribution to cardiovascular disease and a range of other conditions over the course of normal aging. It remains poorly explored, but that will likely change in the years ahead now that there are treatments capable of reducing the amount […]

A two-arm molecule can effectively deplete cancer-protecting cells inside tumors, allowing the immune system to fight off tumors without becoming overactive. The finding, published online in Science Translational Medicine, could lead to new types of cancer immunotherapies. “By effectively removing these immune-suppressive cells inside tumors instead of in the whole […]

New research shows that the QL1101, structurally similar to an existing cancer drug, is a safe and effective alternative for lung cancer treatment. In 2018, lung cancer caused 1.8 million cancer deaths worldwide. It is the most common type of cancer, with non-small cell lung cancers (NSCLCs) accounting for 85% […]

It is interesting to see the sizable degree to which sufficient physical activity can mitigate many of the effects of aging in muscle tissue. It is well known that exercise programs improve muscle function and reduce mortality in later life. In the study reported here, the intent was to distinguish […]

The immune system has many roles. It doesn't just destroy invading pathogens, but also hunts and kills potentially harmful cells, such as those that have become senescent or potentially cancerous. Further, immune cells are intricately involved in the processes of tissue maintenance. Regeneration from injury is a complicated dance of […]

Skoltech researchers and their colleagues from Russia, Germany, and the U.S. have found Prozac to reduce lipid concentrations in juvenile macaques who received the antidepressant for two years, compared to a control group of untreated animals. While none of the monkeys in the study were depressed, the findings still offer a plausible biochemical […]

Researchers from the Mater Hospital Advanced Epilepsy Unit in collaboration with the University of Queensland and Queensland University of Technology are embarking on a joint study to investigate the link between epilepsy and language. Epilepsy affects more than 250,000 Australians with the majority managed on medication, however, one third of […]